A5100638353- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Ion Channels and Receptors
- Respiratory viral infections research
- Influenza Virus Research Studies
- Ion channel regulation and function
- Hearing Loss and Rehabilitation
- Cancer-related molecular mechanisms research
- Medical Research and Treatments
- Foreign Body Medical Cases
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- Restraint-Related Deaths
- Pneumocystis jirovecii pneumonia detection and treatment
- Ear Surgery and Otitis Media
- Allergic Rhinitis and Sensitization
- Connexins and lens biology
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Mesenchymal stem cell research
- High Altitude and Hypoxia
- IL-33, ST2, and ILC Pathways
- NF-κB Signaling Pathways
- Neuroscience and Neural Engineering
- Nuclear Structure and Function
Huazhong University of Science and Technology
2013-2022
Tongji Hospital
2012-2022
Hefei University of Technology
2022
Shanghai Public Health Clinical Center
2013-2015
National Institute of Allergy and Infectious Diseases
2013
National Institutes of Health
2013
Shanghai Medical College of Fudan University
2013
University of Wisconsin–Madison
2010-2012
Ningbo Dahongying University
2010
Capital Medical University
2008
Auditory transduction occurs by opening of Ca 2+ -permeable mechanotransducer (MT) channels in hair cell stereociliary bundles. clearance from bundles was followed rat outer cells (OHCs) using fast imaging fluorescent indicators. Bundle deflection caused a rapid rise that decayed after the stimulus, with time constant about 50 ms. The increased blocking uptake into subcuticular plate mitochondria or inhibiting bundle plasma membrane ATPase (PMCA) pump. Such manipulations raised intracellular...
Background. Asthma is a common polygenic disease, caused by complex interactions between multiple genes and environmental factors. Study of the gene-gene would contribute to new insight into pathogenesis therapeutics asthma. Objective. To evaluate single combined associations eight single-nucleotide polymorphisms loci in five candidate with development asthma Chinese children. Methods. We examined (SNPs) key susceptibility performed SNP association study, haplotype analysis, analysis 479...
Calcium is tightly regulated in cochlear outer hair cells (OHCs). It enters mainly via mechanotransducer (MT) channels and extruded by the plasma membrane calcium ATPase (PMCA)2 isoform of PMCA, mutations which cause hearing loss. To assess how pump expression matches demands Ca(2+) homeostasis, distribution PMCA2 at different locations during development was quantified using immunofluorescence post-embedding immunogold labeling. The confined to stereociliary bundles, first appearing base...
Purpose To provide prognosis of an 18 patient cohort who were confirmed to have H7N9 lung infection in Shanghai. Methods Patients' history, clinical manifestation, laboratory test, treatment strategy and mortality followed recorded for data analysis. Results A total patients had been admitted into Shanghai Public Health Clinical Center from April 8th July 29, 2013. 22.2% the found live poultry contact history 80% aged male with multiple co-morbidities including diabetes, hypertension and/or...
Abstract A novel strain of influenza A(H7N9) virus has emerged in China and is causing mild to severe clinical symptoms infected humans. Some case-patients have died. To further knowledge this virus, we report the characteristics histories 4 early case-patients.
Conclusions: Na+-K+-2Cl– co-transporter isoform 1 (NKCC1) mRNA and protein decrease with increasing age in the cochlear lateral wall of C57BL/6J (C57) mice. The down-regulation NKCC1 may influence K+ transport efficiency homeostasis ion cells, cause irreversible damage cells old C57 Our results indicate that play an important role pathogenesis age-related hearing loss (AHL). Objectives: aim present study was to investigate relationship between functional expression transporter etiology AHL....
Abstract A novel strain of influenza A(H7N9) virus has emerged in China and is causing mild to severe clinical symptoms infected humans. Some case-patients have died. To further knowledge this virus, we report the characteristics histories 4 early case-patients.
Age-related hearing loss (ARHL) is the most common human morbidity. However, molecular mechanisms underlying ARHL are little known. In present study, expression of Cav1.3 calcium channels in C57BL/6J mouse cochlea was investigated. The threshold assessed by auditory brainstem response and expressions at protein mRNA levels were detected immunohistochemistry, western blot, real-time RT-PCR. Associated with increased age, gradually decreased. comparison 4-week-old mice, 14, 24, 48 weeks age...
To present 35 cases of laryngeal foreign bodies (FBs) in pediatric population undergoing misdiagnosis so as to draw on our lessons improve early diagnosis.A retrospective analysis over 15 years was conducted FBs children. Meanwhile, a control group, including 42 without children, set. These patients' clinical data were collected and analyzed identify the risk factors for misdiagnosis.The results chi-square test univariate both showed significant difference time elapsed between discomforts...
Research in mammalian hair cell regeneration is hampered by a lack of vivo model adult mouse inner ear injury. In the present study we investigated effects combination single dose aminoglycoside followed loop diuretic mice. The auditory brainstem response threshold shift, extent and defining characteristics cochlear lesion were assessed verified at different time points post-treatment. Our data indicated that this drug caused rapid extensive death outer cells (OHCs). OHC presented throughout...
Conclusions: The size of cochlear nerve (CN) is atrophic in adult auditory neuropathy spectrum disorder (ANSD) patients compared with non-ANSD sensorineural hearing loss (SNHL) and normal subjects, CN deficiency one the lesions for ANSD patients. Objectives: To evaluate dimensions on magnetic resonance imaging (MRI) confirm hypothesis that Methods: Medical records MRI 24 reviewed retrospectively 20 SNHL volunteers were recruited as control groups. long diameter (LD), short (SD),...
The underlying pathophysiology of idiopathic sudden sensorineural hearing loss (ISSNHL) with vertigo has yet to be identified. aims the current study were (1) elucidate whether there are functional changes intrinsic brain activity in auditory and vestibular cortices ISSNHL patients using resting-state magnetic resonance imaging (rs-fMRI) (2) connectivity alterations related clinical performance associated vertigo. Twelve vertigo, eleven without healthy subjects enrolled this study. Rs-fMRI...
Previous studies have demonstrated that elevated yes‑associated protein (YAP) expression is associated with tumor aggression and poor prognosis in various types of human cancer. However, the clinicopathological significance prognostic value YAP laryngeal squamous cell carcinoma (LSCC) unknown. The aim present study was to identify pattern patients LSCC. mRNA levels were examined fresh archived LSCC samples using reverse transcription‑quantitative polymerase chain reaction,...
Conclusion: The large conductance Ca2+-activated K+ channels (BK) expression is decreased in the cochleae of age-related hearing loss (AHL) mice. BK channel may be associated with AHL.Objective: AHL most common among elderly persons. act as sensors for membrane voltage and intracellular Ca2+ are essential hearing. To investigate distribution C57BL/6J mice, relationship between etiology AHL.Methods: was studied mice at various ages (4, 12, 26, 52 weeks). expressions protein mRNA levels were...