A5037167848- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Electroconvulsive Therapy Studies
- Pharmacological Effects and Toxicity Studies
- Treatment of Major Depression
- Mental Health and Psychiatry
- Psychiatric care and mental health services
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Obsessive-Compulsive Spectrum Disorders
- Electrolyte and hormonal disorders
- Suicide and Self-Harm Studies
- Attention Deficit Hyperactivity Disorder
- Mental Health Treatment and Access
- Employment and Welfare Studies
- Innovations in Medical Education
- Chemical synthesis and alkaloids
- Child and Adolescent Health
- Climate Change and Health Impacts
- Stress Responses and Cortisol
- Chemical synthesis and pharmacological studies
- Health Systems, Economic Evaluations, Quality of Life
Mile End Hospital
2008-2023
Royal London Hospital
2006-2023
East London NHS Foundation Trust
2008-2023
University of Portsmouth
2022-2023
Cornell University
2019-2020
University of Pennsylvania
2019-2020
Centre for Mental Health
2018
University of Worcester
2018
National Health Service
2013-2014
Penn Center for AIDS Research
2013
Background It is unclear whether there a direct link between economic crises and changes in suicide rates. Aims The Lopez-Ibor Foundation launched an initiative to study the possible impact of crisis on European Method Data was gathered analysed from 29 countries included number deaths by men women, unemployment rate, gross domestic product (GDP) per capita, annual growth rate inflation. Results There strong correlation rates all indices except GPD capita but only with women. However,...
Abstract A 12‐month double‐blind trial of carbamazepine vs lithium, given as sole treatment for the prophylaxis bipolar affective disorder, was carried out in 31 patients. All were previously stable on lithium; 15 switched over to and 16 remained lithium. Although overall relapse rate similar 2 groups (6 carbamazepine, 8 lithium), nearly all relapses occurred first month, probably precipitated by lithium withdrawal. Two patients developed a rash withdrawn. More side effects noted during...
Of 600 patients treated with the dopamine agonist drugs bromocriptine and lisuride for functioning pituitary tumours, eight developed drug related psychoses. Symptoms included auditory hallucinations, delusional ideas, appreciable changes in mood. These reactions occurred lower doses of than previously reported remitted when treatment was stopped. The possibility psychiatric side effects should be recognised view strain that may placed on their families.
It is well known that suicidal rates vary considerably among European countries and the reasons for this are unknown, although several theories have been proposed. The effect of economic variables has extensively studied but not climate. Data from 29 covering years 2000–2012 concerning male female standardized (according to WHO), World Bank) climate were gathered. statistical analysis included cluster principal component categorical regression. derived models explained 62.4 % variability...
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The efficacy of depot antipsychotic drugs in the prophylaxis bipolar affective disorder was investigated.Life charts were constructed for 18 outpatients with receiving prophylactic treatment medication. durations episodes compared during periods on or off medication.The subjects suffered fewer relapses and spent significantly less time hospital (P = 0.001) manic, depressive mixed illness antipsychotics.Depot medication may be a useful certain patients disorder.
Pimozide (PMZ), a relatively specific dopamine (DA) receptor blocking drug, was compared to chlorpromazine (CPZ) in double-blind, between-patient clinical trial mania. The lasted 14 days. Twenty-three patients who fulfilled Feighner's criteria for mania entered the (one patient entering on two separate occasions). Both drugs led improvement, with significant effect being noted within 24 hours. According one of rating scales used, initial improvement greater chlorpromazine, probably due its...
The adverse effects of antidepressants include their pharmacological side-effects, toxic effects, interactions with other drugs, and symptoms occurring during withdrawal. focus this paper is on the side-effects.
Article Abstract Background: Lamotrigine has demonstrated efficacy for the acute treatment of depression in bipolar I patients a placebo-controlled, monotherapy study. We describe results 52-week, open-label continuation that trial. Method: Patients meeting DSM-IV criteria disorder with current major depressive episode who completed 7-week, double-blind study were offered 1 year lamotrigine therapy (flexible doses 100-500 mg/day) To maintain blind, first 3 weeks remained blinded while...
In a double-blind, between-patient clinical trial carbamazepine (CBZ) (n = 8) was compared to haloperidol (HP) 9) in patients presenting with mania (DSM III). Seven on HP and 2 CBZ failed complete 4 weeks treatment. of the group this because extrapyramidal side-effects (EPS). Two were withdrawn lack efficacy. Statistically significant improvement seen both groups within first treatment acting more quickly. addition EPS which occurred patients, drowsiness experienced 3 HP, gastrointestinal...
To review prescribing practice concerning valproate, an established human teratogen, for the management of bipolar disorder in women childbearing age.The Prescribing Observatory Mental Health conducted a baseline clinical audit UK, as part quality improvement programme.Six hundred and forty-eight teams from 55 mental health Trusts submitted retrospective treatment data relating to patients with diagnosis disorder.Of sample 6705 patients, 3854 were 50 years age or younger. Valproate was...
Background Studies highlighting the difficulties associated with lithium suggest that role of antipsychotic drugs and mood stabilisers in bipolar disorder should be reconsidered. Aims To review efficacy mode action mania, to consider differences between official guidelines routine clinical practice use these agents for mania. Method Review research, guideline-and practice-based literature. Results Guidelines recommend or valproate as first-line treatments only 'adjuncts' agitation, dangerous...
The objectives of this analysis are to elucidate the clinical significance antidepressant effects with quetiapine by evaluating number needed treat as well time response and remission monotherapy in patients acute bipolar depression. A post-hoc was conducted 542 I or II disorder, (moderate severe depression), randomized 8 weeks double-blind treatment 600 mg/day (n=180), 300 (n=181), placebo (n=181). Number treat, (≥50% reduction from baseline Montgomery–Asberg Depression Rating Scale total...
A 1 year double-blind trial of bromperidol decanoate and fluphenazine was conducted in the maintenance treatment 47 outpatients with schizophrenia. Six patients relapsed on none decanoate, a difference which is statistically significant. No significant differences positive negative symptoms, nor depression measures were found between groups when comparisons made for change score from entry to last visit. However, achieved significantly better changes social disability (Morningside scale)...
The efficacy of an antidepressant typically is assessed by comparing it with placebo using a validated rating scale. This type analysis, however, does not translate well to the clinical settings. For clinicians, more meaningful measure number needed treat (NNT). objective this analysis assess duloxetine in terms NNT. Data were obtained from nine trials designed and safety as treatment for major depressive disorder. These studies examined 8-9 weeks acute duloxetine. NNT estimates determined...
Plasma cortisol levels were elevated in a large proportion of samples from manic patients. Although correlation was found between clinical ratings the severity mania and degree elevation daytime levels, some patients with low had levels. During treatment haloperidol, returned to normal earlier that state. The underlying mechanisms are discussed.
Abstract Aripiprazole has recently received approval for the treatment of moderate to severe manic episodes in bipolar I disorder and prevention new aripiprazole-responsive patients. differs from other antipsychotics its pharmacology, need prescribing guidance UK was identified. A multidisciplinary panel convened November 2007. This report describes consensus agreed during meeting on optimal approach aripiprazole: how best initiation of, switching to, with aripiprazole management strategies...
In a series of thirty-six patients treated with clozapine we report four cases who developed upper gastrointestinal symptoms suggestive reflux oesophagitis within 6 weeks starting this drug. Subsequent endoscopic examination revealed moderately severe erosive in three them. Of these one had received treatment for peptic ulcer the past but other two no previous history any disorder. The pharmacology relation to gastro-oesophageal is discussed.
Fifteen acutely ill patients (8 male, 7 female) aged 19 to 63 who met DSM-III criteria for schizophrenic disorder or schizophreniform participated in a 4-week open trial of raclopride. The starting dose raclopride was 2 mg increasing 4 twice daily the first week, further increments 6 at day 14, and 8 21 depending on response. Weekly assessments were made using BPRS, Montgomery Schizophrenia Scale, Krawiecka-Goldberg Scale Clinical Global Impression Scale. Extra-pyramidal symptoms other...