A5052237071- Autophagy in Disease and Therapy
- Plant tissue culture and regeneration
- RNA modifications and cancer
- Plant Virus Research Studies
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
Gregor Mendel Institute of Molecular Plant Biology
2023-2024
Austrian Academy of Sciences
2023-2024
Vienna Biocenter
2023-2024
Medical University of Vienna
2023-2024
UFMylation involves the covalent modification of substrate proteins with UFM1 (Ubiquitin-fold modifier 1) and is important for maintaining ER homeostasis. Stalled translation triggers ER-bound ribosomes activates C53-mediated autophagy to clear toxic polypeptides. C53 contains noncanonical shuffled ATG8-interacting motifs (sAIMs) that are essential ATG8 interaction initiation. However, mechanistic basis sAIM-mediated remains unknown. Here, we show sAIMs conserved across eukaryotes but...
Abstract RNA viruses co-opt the host endomembrane system and organelles to build replication complexes for infection. How responds these membrane perturbations is poorly understood. Here, we explore autophagic response of Arabidopsis thaliana three that hijack different cellular compartments. Autophagy significantly induced within systemically infected tissues, its disruption rendering plants highly sensitive Contrary being an antiviral defense mechanism as previously suggested, quantitative...