A5101970406- Cell death mechanisms and regulation
- Selenium in Biological Systems
- Mitochondrial Function and Pathology
- Plant Molecular Biology Research
- Cancer-related Molecular Pathways
- Gene expression and cancer classification
- Nanoparticles: synthesis and applications
- Anesthesia and Neurotoxicity Research
- Nitrogen and Sulfur Effects on Brassica
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Spectroscopy and Quantum Chemical Studies
- Biological Control of Invasive Species
- Cassava research and cyanide
- Adipose Tissue and Metabolism
- Graphene and Nanomaterials Applications
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
- Gout, Hyperuricemia, Uric Acid
- Calpain Protease Function and Regulation
- Plant Genetic and Mutation Studies
- Mathematical Biology Tumor Growth
- Glutathione Transferases and Polymorphisms
- Carbon and Quantum Dots Applications
- IL-33, ST2, and ILC Pathways
Hubei University of Medicine
2025
Renji Hospital
2022
Shanghai Jiao Tong University
2022
China Agricultural University
2011-2021
Nanjing Medical University
2021
Zhejiang University
2012-2020
Xiangtan University
2020
Huaihua University
2020
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2019
Colorado State University
2017-2018
SOX family proteins belong to the high-mobility-group (HMG) domain-containing transcription factors, and function as key players regulate embryonic development cell fate determination. The highly related group C Sox genes Sox4 Sox11 are widely expressed in of mouse retina share a similar expression pattern with each other this process. Here, investigate roles retinal development, Sox4, Sox11, Sox4/Sox11 conditional knock-out (CKO) mice deletion retinas were generated. Our studies...
Summary Stanleya pinnata not only hyperaccumulates selenium (Se) to 0.5% of its dry weight, but also exhibits higher tissue Se‐to‐sulfur (S) ratios than other species and surroundings. To investigate the mechanisms underlying this Se enrichment, we compared S. with nonhyperaccumulators elata Brassica juncea for selenate uptake in long‐ (9 d) short‐term (1 h) assays, using different concentrations competitor sulfate. Different sulfate pre‐treatments (0, 0.5, 5 mM, 3 were tested effects on...
Abstract Azolla caroliniana Willd. is widely used as a green manure accompanying rice, but its ecological importance remains unclear, except for ability to fix nitrogen in association with cyanobacteria. To investigate the impacts of cultivation on methane emissions and environmental variables paddy fields, we performed this study plain Dongting Lake, China, 2014. The results showed that dual cropping significantly suppressed from paddies, likely due increase redox potential root region...
The wide application of multi-walled carbon nanotubes (MWCNT) has raised serious concerns about their safety on human health and the environment. However, potential harmful effects MWCNT remain unclear contradictory. To clarify potentially toxic to elucidate associated underlying mechanisms, lung adenocarcinoma A549 cells were examined at both cellular protein level. Cytotoxicity genotoxicity examined, followed by a proteomic analysis (2-DE coupled with LC-MS/MS) response MWCNT. Our results...
Abstract Melatonin is a key hormone that regulates circadian rhythms, metabolism, and reproduction. However, the mechanisms of melatonin synthesis secretion have not been fully defined. The purpose this study was to investigate functions LIM homeobox transcription factor Isl1 in regulating porcine pineal gland. We found highly expressed melatonin‐producing cells Further functional studies demonstrate knockdown cultured primary pinealocytes results decline arylalkylamine N‐acetyltransferase (...
In plants, the posttranslational modification small ubiquitin-like modifier (SUMO) is involved in regulating several important developmental and cellular processes, including flowering time control responses to biotic abiotic stresses. Here, we report two proteases, SUMO PROTEASE RELATED TO FERTILITY1 (SPF1) SPF2, that regulate male female gamete embryo development remove from proteins vitro vivo. spf1 mutants exhibit abnormal floral structures development, while spf2 largely a wild-type...
Electron−phonon (e-ph) coupling dynamics in Au nanorods are studied with femtosecond transient depolarization experiments. exhibit strongly anisotropic e-ph dynamics. It is considered to arise from different weights of pump energy assigned two polarization directions because the anisotropy rather than an intrinsic process. The kinetics measured by experiments cannot be simply described a single exponential function but integral components contributed random distribution at all aqueous...
The role of protein dynamics in guiding multistep electron transfer is explored the photosynthetic reaction center Rhodobacter sphaeroides . energetics charge-separated intermediates, P(+)B(A)(-) and P(+)H(A)(-) (P initial donor bacteriochlorophyll pair B(A) H(A) are early bacteriopheophytin acceptors, respectively), were systematically varied a series mutants. A fast phase recombination was resolved that very sensitive to driving force. Either increasing or decreasing relative free energy...
Members of a large family small GTP-binding proteins, termed Rabs in mammalian cells or Ypt and Sec4 yeast, regulate vesicular traffic all eukaryotic cells. These proteins are able to bind membranes because they modified by the type II geranylgeranyltransferase (GGTase-II), multisubunit complex. Component A, encoded choroideremia gene humans, is an escort protein that brings component B, catalytic alpha/beta heterodimer. Mutations subunits yeast GGTase-II (Bet2p/Mad2p) disrupt membrane...
Methyl methanesulfonate (MMS) is an alkylating agent that can induce cell death through apoptosis and necroptosis. The molecular mechanisms underlying MMS-induced have been studied extensively; however, little known about the mechanism for Therefore, we first established necroptosis model using human lung carcinoma A549 cells. It was found that, within a 24-h period, although MMS at concentrations of 50, 100, 200, 400, 800 μM DNA damage, only higher (400 μM) treatment lead to in cells, as it...
Benzo(a)pyrene (BaP), a typical environmental carcinogen, can induce cell death both by protein 53 or tumor (p53)-independent and -dependent pathways. However, little is known about the molecular mechanisms of p53-independent pathways in BaP-induced death. In this study, cells with different genetic background (including p53-proficient human fetal lung fibroblast lines (MRC-5), p53-deficient non-small-cell carcinoma (H1299), p53-knockdown (MRC-5 p53−/− )) were used to establish models The...
Paraspeckle protein 1 (PSPC1) was first identified as a structural of the subnuclear structure termed paraspeckle. However, exact physiological functions PSPC1 are still largely unknown. Previously, using proteomic approach, we have shown that exposure to cisplatin can induce expression in HeLa cells, indicating possible involvement for DNA damage response (DDR). In current study, role DDR examined. First, it found treatment could indeed protein. Abolishing by siRNA significantly inhibited...
Background: The plant Stanleya pinnata hyperaccumulates Se up to 0.5% of its dry weight in organic forms, whereas the closely related elata does not hyperaccumulate Se.ATP sulfurylase (ATPS) can catalyze formation adenosine 5′-phosphoselenate (APSe) from ATP and selenate.We investigated S. ATPS2 isoform (SpATPS2) assess possible role hyperaccumulation.Methods: ATPS expression activity was compared two species.The protein sequences were modeled.Sub-cellular locations analyzed using GFP...