A5102988282- Hormonal Regulation and Hypertension
- Eicosanoids and Hypertension Pharmacology
- Chemical synthesis and alkaloids
- Thermal Regulation in Medicine
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Anatomy and Medical Technology
- Renal Diseases and Glomerulopathies
- Neonatal and fetal brain pathology
- Bone and Dental Protein Studies
- Nicotinic Acetylcholine Receptors Study
- Genetics, Aging, and Longevity in Model Organisms
- Chronic Kidney Disease and Diabetes
- Traumatic Brain Injury and Neurovascular Disturbances
- Surgical Simulation and Training
- Extracellular vesicles in disease
- Augmented Reality Applications
- Cardiovascular Syncope and Autonomic Disorders
- Shoulder Injury and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- Heterotopic Ossification and Related Conditions
- Thermoregulation and physiological responses
- Genetic Syndromes and Imprinting
- Immune cells in cancer
Xuzhou Medical College
2024-2025
Southern Medical University
2006-2024
Jiaxing University
2023
Ministry of Education of the People's Republic of China
2019
Nanfang Hospital
2016
Abstract Accumulation of obsolete biomolecules can accelerate cell senescence and organism aging. The two efficient intracellular systems, namely the ubiquitin‐proteasome system autophagy‐lysosome system, play important roles in dealing with cellular wastes. However, how multicellular organisms orchestrate processing molecules delay aging remains unclear. Herein, it is shown that prevention exosome release by GW4869 or Rab27a −/− accelerated various cells mice, while stimulating nutrient...
Major depressive disorder is the most common mental illness. Mounting evidence indicates that astrocytes play a crucial role in pathophysiology of depression; however, underlying molecular mechanisms remain elusive. Compared with other neuronal cell types, are enriched for arachidonic acid metabolism. Herein, we observed brain-region-specific alterations epoxyeicosatrienoic (EET) signaling, which an metabolic pathway, both mouse model depression and postmortem samples from patients...
Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few evaluated role of peripheral organs in depression. Here, we show that liver activates an intrinsic metabolic pathway can modulate depressive-like behavior. We find chronic stress specifically increases protein levels monomeric and oligomeric soluble epoxide hydrolase (sEH), key enzyme...
Leptin protein was thought to be unique leptin receptor (LepR), but the phenotypes of mice with mutation in LepR [ db/db (diabetes)] and ob/ob (obese)] are not identical, cause remains unclear. Here, we show that , had defect tenotomy-induced heterotopic ossification (HO), implicating alternative ligand(s) for might involved. Ligand screening revealed ANGPTL4 (angiopoietin-like 4), a stress fasting-induced factor, elicited from brown adipose tissue after tenotomy, bound on PRRX1 +...
Memory impairment in chronic pain patients is substantial and common, few therapeutic strategies are available. Chronic pain-related memory has susceptible unsusceptible features. Therefore, exploring the underlying mechanisms of its vulnerability essential for developing effective treatments. Here, combining two spatial tests (Y-maze test Morris water maze), we segregated mice into impairment-susceptible -unsusceptible subpopulations a neuropathic model induced by constrictive injury...
Cytisine derivatives are a group of alkaloids containing the structural core cytisine, which mainly distributed in Fabaceae plants with wide range pharmacological activities, such as resisting inflammation, tumors, and viruses, affecting central nervous system. At present, total 193 natural cytisine its have been reported, all derived from L-lysine. In this study, were classified into eight types, namely type, sparteine albine angustifoline camoensidine cytisine-like tsukushinamine...
Objective To explore therapeutic mechanism of angiotensin-converting enzyme inhibitor(Captopril) in renal ischemia reperfusion(I/R) injury. Methods Wistar rats were randomly divided into sham operation group(Sham group), ischemia-reperfusion group(I/R captopril-treated group(CAP I/R model was made through ligating one side vessel.Renal function indexes including SCr and BUN detected biochemical analysis.Changes tissue observed by pathological section.ELISA detection used to determine...