A5070836879- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Appendicitis Diagnosis and Management
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Gastrointestinal disorders and treatments
- Amoebic Infections and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Case Reports on Hematomas
- Anesthesia and Pain Management
- Abdominal Trauma and Injuries
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 and healthcare impacts
- Extracellular vesicles in disease
- Gastrointestinal Tumor Research and Treatment
- Pain Management and Opioid Use
- Colorectal Cancer Treatments and Studies
- Intestinal Malrotation and Obstruction Disorders
- Cancer, Lipids, and Metabolism
- Sepsis Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
Tan Tock Seng Hospital
2014-2024
National University of Singapore
2022
Nanyang Technological University
2022
Singapore General Hospital
2020
Manchester Royal Infirmary
2007-2011
Mater Misericordiae University Hospital
2011
Chang Gung University
2009
Kaohsiung Chang Gung Memorial Hospital
2009
Northampton General Hospital
2000
Children's Hospital of Philadelphia
1993
Abstract Background Adult pyogenic liver abscess ( PLA ) is a major hepato‐biliary infection. We aim to identify risk factors associated with therapy failure. Methods Retrospective study of 741 patients (2001–2011) and comparison earlier data (1994–1997). Risk failure were identified multivariate analysis. Results Incidence 86/100 000 admissions, average size 5.75 cm. 68% secondary K lebsiella pneumoniae there increasing extended‐spectrum beta‐lactamase ESBL resistance. Compared 1990s, an...
Percutaneous cholecystostomy (PC) is an established treatment for high surgical risk patients with acute cholecystitis. This paper studies factors predictive of mortality and eventual cholecystectomy.A retrospective review all who underwent PC from March 2005 to 2015 was performed. Patient demographics, clinical features, comorbidity profile, grade cholecystitis, interval between cholecystitis diagnosis PC, method were studied. Length stay, complications, readmission rate, cholecystectomy...
Ranson's score (RS) and Glasgow (GS) have been utilized to stratify the severity of acute pancreatitis (AP). The aim this study was validate RS GS for stratifying audit our experience managing AP.We conducted a retrospective review patients treated AP from July 2009 September 2016. Final determined using revised Atlanta classification. Mortality complications were analyzed.From 2016, total 675 with diagnosis admitted at hospital. Of them, 669 who had sufficient data analyzed. Their average...
// Nikhil Gupta 1 , Jung Eun Park Wilford Tse Jee Keem Low 2 Oi Lian Kon 3 Neil McCarthy 4 and Siu Kwan Sze School of Biological Sciences, Nanyang Technological University, Singapore Department Surgery, Tan Tock Seng Hospital, National Cancer Centre Singapore, Division Medical for Immunobiology, The Blizard Institute, Bart’s London Medicine Dentistry, Queen Mary University London, United Kingdom Correspondence to: Sze, email: sksze@ntu.edu.sg Keywords: pancreatic cancer; hypoxia...
Acute pancreatitis (AP) is a common surgical condition, with severe AP (SAP) potentially lethal. Many prognostic indices, including; acute physiology and chronic health evaluation II score (APACHE II), bedside index of severity in (BISAP), Glasgow score, harmless (HAPS), Ranson's sequential organ failure assessment (SOFA) evaluate predict mortality.
Previous studies have evaluated quality of life (QoL) in patients who underwent laparoscopic cholecystectomy (LC) for cholelithiasis. The purpose this study was to evaluate QoL after index admission LC diagnosed with acute cholecystitis (AC) using the Gastrointestinal Quality Life Index (GIQLI) questionnaire.Patients ≥21 years admitted Tan Tock Seng Hospital, Singapore AC and between February 2015 January 2016 were GIQLI questionnaire preoperatively 30 days postoperatively.A total 51 (26...
Background Staging is vital in guiding therapeutic approach patients diagnosed with hepatocellular carcinoma (HCC). Our study's goal to compare paradigms the Barcelona Clinic Liver Cancer (BCLC) and Hong Kong (HKLC) systems, evaluate use of both a local context, comparing their prognostic ability efficacy management HCC. Methods Seven hundred sixty-six between 2010 2015 were identified staged according BCLC HKLC. Both system's performances compared using Akaike information criterion (AIC),...
We evaluated the safety and feasibility of delayed urgent laparoscopic cholecystectomy (LC) performed beyond 72 hours to overcome logistical difficulties in performing early LC within admission with acute cholecystitis (AC), avoid earlier readmission recurrent AC patients awaiting interval. Patients admitted were scheduled for LC. who underwent compared those had surgery. Fifty consecutive 2 weeks admission. There no conversions bile duct injuries. Delayed surgery (n=36) neither prolonged...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Extracellular vesicles (EVs) mediate critical intercellular communication within healthy tissues, but are also exploited by tumour cells to promote angiogenesis, metastasis, and host immunosuppression under hypoxic stress. We hypothesize that tumours synthesize hypoxia-sensitive proteins for packing into EVs modulate their microenvironment cancer progression. In the current report, we employed a heavy isotope pulse/trace quantitative proteomic approach study hypoxia sensitive in...
Hypoxia is an environmental cue that associated with multiple tumorigenic processes such as immunosuppression, angiogenesis, cancer invasion, metastasis, drug resistance, and poor clinical outcomes. When facing hypoxic stress, cells initiate several adaptive responses cell cycle arrest to reduce excessive oxygen consumption co-activation of oncogenic factors. In order identify the critical novel proteins for hypoxia responses, we used pulsed-SILAC method trace active cellular translation...
Elderly patients (≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly (< years): Propensity score-matched analysis