A5065514884- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Global Public Health Policies and Epidemiology
- Estrogen and related hormone effects
- Genomics and Chromatin Dynamics
- Health disparities and outcomes
- Resilience and Mental Health
- Health and Lifestyle Studies
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Advanced Breast Cancer Therapies
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Maternal Mental Health During Pregnancy and Postpartum
- Molecular Biology Techniques and Applications
- Hedgehog Signaling Pathway Studies
- BRCA gene mutations in cancer
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Mental Health Treatment and Access
Princess Margaret Cancer Centre
2022-2023
McMaster University
2017-2022
University Health Network
2022
University of the West Indies
2018
Abstract Triple negative breast cancers (TNBC) are highly aggressive and lack specific targeted therapies. Recent studies have reported high expression of the transcription factor Kaiso in triple tumors, this correlates with their increased aggressiveness. However, little is known about clinical relevance growth survival TNBCs. Herein, we report that depletion attenuates TNBC cell proliferation, delays tumor onset mice xenografted MDA-231 cells. We further demonstrate cells increases...
Triple-negative breast cancer (TNBC) is most prevalent in young women of African ancestry (WAA) compared to other ethnicities. Recent studies found a correlation between high expression the transcription factor Kaiso, TNBC aggressiveness, and ethnicity. However, little known about Kaiso localization patterns tissues WAA. Herein, we analyze (Nigerian), Caribbean (Barbados), American (AA), Caucasian (CA) women. Formalin-fixed paraffin embedded (FFPE) tissue blocks from Nigeria Barbados were...
Women of African ancestry (WAA) are disproportionately affected by triple-negative breast cancer (TNBC), which remains one the most clinically challenging (BCa) subtypes. This study investigated prevalence TNBC and epidemiological trends for BCa in Barbados, a Caribbean island with high percentage ancestry.Pathology reports all cases between 2007 2016 were collected from sole hospital Barbados reviewed. The clinicopathological data included age, tumor grade, lymph node status, hormone...
Mortality from triple negative breast cancer (TNBC) is significantly higher in African American (AA) women compared to White (WA) emphasizing ethnicity as a major risk factor; however, the molecular determinants that drive aggressive progression of AA-TNBC remain elusive. Here, we demonstrate for first time cells are inherently aggressive, exhibiting elevated growth, migration, and stem-like phenotype WA-TNBC cells. Meta-analysis RNA-sequencing data multiple AA- cell lines shows enrichment...
Triple negative breast cancer (TNBC) is an aggressive subtype that disproportionately affects women of African ancestry (WAA) and often associated with poor survival. Although there a high prevalence TNBC across West Africa in the diaspora, has been no comprehensive genomics study to investigate mutational profile ancestrally related Caribbean Africa.This multisite cross-sectional used 31 formalin-fixed paraffin-embedded (FFPE) samples from Barbadian Nigerian participants. High-resolution...
Abstract Breast cancer (BCa) is the most frequently diagnosed female and a leading cause of deaths worldwide, regardless increased awareness improved therapies. Triple-negative breast (TNBC) one challenging BCa subtypes as it highly heterogeneous, metastatic in nature has limited targeted TNBC prevalent young women African ancestry (WAA), who despite having lower rates, have disproportionately higher mortality rate compared to European (WEA). However, for this racial disparity currently...
Abstract Despite increased awareness, early detection and improved therapies in the past 20 years, breast cancer (BC) remains most frequent female a leading cause of deaths worldwide. One clinically challenging BC is Triple Negative Breast Cancer (TNBC) subtype that estrogen receptor (ER), progesterone (PR) & human epidermal growth factor receptor-2 (HER2) negative. TNBC tumors are aggressive metastatic, have poor prognosis since they cannot be treated with standard (Tamoxifen or...
Abstract Women of African ancestry (WAA) are disproportionately affected by the aggressive triple negative breast cancer (TNBC) subtype that is often associated with high recurrence rates and metastasis. Although there a prevalence TNBC across West Africa in women diaspora, has been no comprehensive genomics study to investigate mutational profile ancestrally related Caribbean Africa. To shed more light on this phenomenon, whole exome sequencing (WES) was performed 31 formalin-fixed...
Abstract Background and Aim: Triple-negative breast cancer (TNBC) is a very aggressive subtype of characterized by the absence estrogen receptor (ER), progesterone (PR) HER2 expression. Mortality from TNBC significantly higher in African American (AA) women comparison to White (WA) (5-year relative survival only 14% for AA 36% WA) even though incidence rates are lower women. Irrespective stage at diagnosis, AA-TNBC more with metastasis poorer than WA-TNBC; therefore, it imperative understand...