A5029186579- Animal Nutrition and Physiology
- Cancer-related molecular mechanisms research
- Meat and Animal Product Quality
- Genetic and phenotypic traits in livestock
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Gut microbiota and health
- Genetic Mapping and Diversity in Plants and Animals
- Animal Behavior and Welfare Studies
- Antimicrobial Peptides and Activities
- MicroRNA in disease regulation
- Protein Hydrolysis and Bioactive Peptides
- Colorectal Cancer Treatments and Studies
- Probiotics and Fermented Foods
- Lipid metabolism and biosynthesis
- Colorectal Cancer Screening and Detection
- Genetic Syndromes and Imprinting
- Biochemical effects in animals
- Clostridium difficile and Clostridium perfringens research
- Veterinary medicine and infectious diseases
- Vitamin C and Antioxidants Research
- Salivary Gland Disorders and Functions
- Exercise and Physiological Responses
- RNA Research and Splicing
- Coccidia and coccidiosis research
Center for Research in Agricultural Genomics
2018-2024
Universitat Autònoma de Barcelona
2020-2024
Institut Català d'Oncologia
2022
Institut d'Investigació Biomédica de Bellvitge
2022
Delacon Biotechnik (Czechia)
2020
National Research Development Institute for Animal Biology and Nutrition
2020
In addition to its value in meat production, the pig is an interesting animal model for human digestive tract studies due physiological similarities. The aim of this study was describe microbiome composition, distribution and interaction along Iberian intestinal role whole-body energy homeostasis. V3-V4 region 16S rRNA gene amplified sequenced from microbiomes five gut sections (duodenum, jejunum, ileum, proximal distal colon) thirteen castrated male pigs. A total 1,669 operational taxonomic...
Abstract The gut microbiota has been evolving with its host along the time creating a symbiotic relationship. In this study, we assess role of genome in modulation composition pigs. Gut compositions were estimated through sequencing V3-V4 region 16S rRNA gene from rectal contents 285 A total 1,261 operational taxonomic units obtained and grouped 18 phyla 101 genera. Firmicutes (45.36%) Bacteroidetes (37.47%) two major obtained, whereas at genus level Prevotella (7.03%) Treponema (6.29%) most...
Abstract Background Intramuscular fat (IMF) content and its fatty acid (FA) composition are typically controlled by several genes, each with a small effect. In the current study, to pinpoint candidate genes putative regulators involved in FA composition, we performed multivariate integrative analysis between intramuscular transcriptome profiles of porcine longissimus dorsi (LD) muscle. We also carried out combination network, regulatory impact factor (RIF), silico prediction target...
The aim of this work was to study the genetic basis backfat expression lipid-related genes associated with meat quality traits in pigs. We performed a genome-wide association gene measured 44 by qPCR and PorcineSNP60 BeadChip genotypes 115 Iberian x Landrace backcross animals. A total 193 expression-associated SNPs located 19 chromosomal regions were levels ACSM5, ELOVL6, FABP4, FADS2, SLC27A4 genes. Three quantitative trail loci (eQTLs) corresponding FADS2 classified as cis-acting eQTLs,...
Abstract Meat quality has an important genetic component and can be modified by the fatty acid (FA) composition amount of fat contained in adipose tissue muscle. The present study aimed to find genomic regions associated with FA backfat muscle ( longissimus dorsi ) 439 pigs three different backgrounds but having Iberian breed common. Genome-wide association studies (GWAS) were performed between 38,424 single-nucleotide polymorphisms (SNPs) covering pig genome 60 phenotypic traits related...
Abstract Fatty acids (FAs) play an essential role as mediators of cell signaling and signal transduction, affecting metabolic homeostasis determining meat quality in pigs. However, FAs are transformed by the action several genes, such those encoding desaturases elongases lipogenic tissues. The aim current work was to identify candidate biological processes, pathways involved modulation intramuscular FA profile from longissimus dorsi muscle. gas chromatography methyl esters gene expression...
Phytogenic actives (PA) are plant-derived natural bioactive compounds that may promote livestock health and well-being, as well improve growth performance production efficiency. The current study aims to evaluate their effects on sows offspring. Eighty-one hyperprolific (up parity 7) were assigned 3 experimental treatments. Control offered a nonsupplemented diet during gestation lactation, treated fed the control supplemented with 1 g/kg of blend PA (BPA) in lactation (L) or (GL). An...
Abstract Intramuscular fat content and its fatty acid composition affect porcine meat quality nutritional value. The present work aimed to identify genomic variants regulating the expression in muscle (Longissimus dorsi) of 45 candidate genes for lipid metabolism three experimental backcrosses based on Iberian breed. Expression genome-wide association studies (eGWAS) were performed between gene values, measured by real-time quantitative PCR, genotypes 38,426 SNPs distributed along all...
Abstract There is a high interest on gut health in poultry with special focus consequences of the intestinal diseases, such as coccidiosis and C . perfringens -induced necrotic enteritis (NE). We developed custom gene expression panel, which could provide snapshot variation under challenging conditions. Ileum studies were performed through throughput reverse transcription quantitative real-time polymerase chain reaction. A deep review bibliography was done genes related to selected for...
The gut microbiome is a potential modifiable risk factor for colorectal cancer (CRC). We re-analyzed all eight previously published stool sequencing data and conducted an MWAS meta-analysis. used cross-validated LASSO predictive models to identify signature predicting the of CRC precancerous lesions. These were validated in new study, Colorectal Cancer Screening (COLSCREEN), including 156 participants that recruited screening context. meta-analysis identified 95 bacterial species...
The intramuscular fat content and fatty acid composition of porcine meat have a significant impact on its quality nutritional value. This research aimed to investigate the expression 45 genes involved in lipid metabolism longissimus dorsi muscle three experimental pig backcrosses, with 25% Iberian background. To achieve this objective, we conducted an Genome-Wide Association Study (eGWAS) using gene levels measured by high-throughput real-time qPCR for target genotypes from PorcineSNP60...
IGF2:g.3072G>A polymorphism has been described as the causal mutation of a maternally imprinted QTL for muscle growth and fat deposition in pigs. The objective current work was to study association between IGF2 gene expression its effect on fatty acid composition adipose tissue different pig genetic backgrounds. A cis-eQTL region associated with mRNA identified an eGWAS 355 animals. located this genomic interval IGF2g.3072G>A most significant SNP, explaining 25% variance. Significant...
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) are essential with antagonistic inflammatory functions that play vital roles in metabolic health immune response. Current commercial swine diets tend to over-supplement n-6 PUFAs, which may increase the likelihood of developing diseases affect overall well-being animals. However, it is still poorly understood how n-6/n-3 PUFA ratios porcine transcriptome expression messenger RNAs (mRNAs) microRNAs (miRNAs) might regulate...
This study was conducted to investigate the effects of dietary supplementation porcine digestible peptides (PDP), spray-dried plasma (SDP), or a combination both, on growth performance and expression genes related intestinal function weaned pigs. A total 180 piglets (trial 1) 198 2) were used evaluate partial substitution soybean ingredients with 2% SDP PDP 1), 3% 1% (SDP-PDP; trial during pre-starter period (0–14 days). The gene 56 quantified in qPCR platform jejunum ileum samples obtained...
mir-33a and mir-33b are co-transcribed with the SREBF2 SREBF1 transcription factors, respectively. The main role of is regulation genes involved in fatty acid metabolism, while regulates participating cholesterol biosynthesis uptake. Our objective was to study expression both miR-33a miR-33b, together their host SREBF genes, liver, adipose tissue muscle better understand miR-33a/b lipid metabolism pigs. In our study, miR-33a, miR-33b tissue, studied 42 BC1_LD (25% Iberian x 75% Landrace...
The selection in commercial swine breeds for meat-production efficiency has been increasing among the past decades, reducing intramuscular fat content, which changed sensorial and technological properties of pork. Through processes natural adaptation selective breeding, accumulation mutations driven genetic divergence between pig breeds. most common well-studied are single-nucleotide polymorphisms (SNPs). However, insertions deletions (indels) usually represents a fifth part detected should...
Abstract The intramuscular oleic‐to‐stearic fatty acid ratio (C18:1 n ‐9/C18:0) is an important indicator of the biosynthesis and desaturation acids in muscle. By using RNA‐Seq approach muscle samples from 32 BC1_DU (25% Iberian 75% Duroc) pigs with divergent values (high: H low: L) C18:1 ‐9/C18:0 ratio, a total 81 differentially expressed genes (DEGs) were identified. Functional analyses DEGs indicate that mainly peroxisome proliferator‐activated receptor signaling pathway (associated...
Abstract Background : Porcine digestive peptides (PDP) have proven to be a valid substitute for other high-quality dietary protein sources piglets, like spray-dried plasma (SDP), but knowledge about their influence on intestinal function is still scarce. This study was conducted investigate the effects of PDP, SDP or combination both growth performance and weaned pigs. Results A total 180 piglets (Trial 1) 198 2) were used evaluate partial substitution soybean ingredients with 2% PDP 1), 3%...
Abstract Background The improvement of sow prolificacy by breeding has increased the number piglets produced per year. However, intrauterine crowding and/or growth restriction typically observed in hyperprolific sows impairs foetal which decreased average individual birthweight, with a larger proportion low birthweight (LBW) pigs born litter poor gut development and compromised postnatal performance. Phytogenic compounds (PC) are plant-derived natural bioactive substances that can be used...
<title>Abstract</title> Fatty acids (FAs) play an essential role as mediators of cell signaling and signal transduction, affecting metabolic homeostasis determining meat quality in pigs. However, FAs are transformed by the action several genes, those encoding desaturases elongases lipogenic tissues. The aim current work was to identify candidate biological processes pathways involved modulation intramuscular FA profile from<italic>longissimus dorsi</italic>(LD) muscle. gas chromatography...