A5001240150- Neural and Behavioral Psychology Studies
- Neurobiology of Language and Bilingualism
- Memory Processes and Influences
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Reading and Literacy Development
- Visual perception and processing mechanisms
- Neuroethics, Human Enhancement, Biomedical Innovations
- Advanced Neuroimaging Techniques and Applications
- Spatial Neglect and Hemispheric Dysfunction
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Neuroscience, Education and Cognitive Function
- Autism Spectrum Disorder Research
- Pain Management and Placebo Effect
- Cognitive Science and Mapping
- Sexuality, Behavior, and Technology
- Motor Control and Adaptation
- Epistemology, Ethics, and Metaphysics
- Stroke Rehabilitation and Recovery
- Neonatal and fetal brain pathology
- Neuroscience and Music Perception
- Vestibular and auditory disorders
- Hemispheric Asymmetry in Neuroscience
- Computability, Logic, AI Algorithms
Niagara University
2011-2020
Washington University in St. Louis
1998-2019
Howard Hughes Medical Institute
2003
Neurological Surgery
1993-2002
Mallinckrodt (Ireland)
2000
Hope Center for Neurological Disorders
1996-1998
Mallinckrodt (United States)
1995-1998
Saint Louis University
1996
Neurology, Inc
1996
Institute of Neurobiology
1996
We studied regional cerebral blood flow using the H2(15)O method while normal subjects performed four similar tasks involving three-letter word beginnings (stems). Prior to each task, a list of words. Local was then monitored during 40-sec period (i) silently viewed stems, (ii) completed stems form first words come mind, but were not any study (baseline), (iii) and half them could (priming), or (iv) tried recall words, these (memory). There three major findings. The memory task engaged right...
Positron emission tomography (PET) was used to investigate the functional brain anatomy associated with short-term maintenance of linguistic information. Subjects were asked retain five related words, unrelated or pseudowords silently for duration a 40 sec PET scan. When activity during these tasks compared visual fixation control task, increases found bilaterally in dorsolateral prefrontal cortex and cerebellum, medially supplementary motor area. Furthermore, effects stimulus condition...
Functional neuroimaging with positron emission tomography was used to study brain areas activated during memory retrieval. Subjects (n = 15) recalled items from a recent episode (episodic memory) two paired-associate recall tasks. The tasks differed in that PICTURE RECALL required pictorial retrieval, whereas AUDITORY WORD word Word REPETITION and REST served as reference Comparing repetition revealed the following observations. (1) Right anterior prefrontal activation (similar seen several...
Abstract Positron emission tomography (PET) was used to investigate the functional anatomy of auditory and phonological processing. Stimulus sets were designed determine areas brain significantly activated during speech nonspeech acoustic processing for stimuli with or without rapidly changing cues. Performance target detection tasks using these stimulus produced increased activation in superior temporal, frontal opercular, medial (SMA) cortices, relative a visual fixation control task....
1. Data from a series of positron emission tomography (PET) experiments were analyzed with two goals. The first goal was to determine whether there reliable differences in prefrontal cortex activation across different speech production tasks. Such are important determining functional subdivisions within cortex. second any gender the 2. To accomplish these goals, PET subtraction images generated for each tasks (stem completion and verb generation). For stem task, subjects viewed word stems...
Previous studies using positron emission tomography (PET) report blood flow changes in superior and middle temple gyri associated with auditory language tasks (Petersen et al., 1988, 1989; Wise 1991; Demonet 1992; Howard 1992 Sergent Zatorre Petrides 1993; Raichle 1994; Fiez 1995). An important issue is whether these reflect the activation of a single functional region or multiple regions distinct contributions. In present study, we examined this by focusing upon two for which have...
Abstract To distinguish areas involved in the processing of word meaning (semantics) from other regions lexical more generally, subjects were scanned with positron emission tomography (PET) while performing tasks, three which required varying degrees semantic analysis and one that phonological analysis. Three closely apposed left inferior frontal cortex right cerebellum significantly active above baseline but not nonsemantic task. The activity two was modulated by difficulty judgment. Other...
Controlled processing is central to episodic memory retrieval. In the present study, neural correlates of sustained, as well transient, components were explored during controlled retrieval using a mixed blocked event-related functional magnetic resonance imaging paradigm. Results from 29 participants suggest that certain regions in prefrontal cortex, including anterior left inferior cortex near Brodmann's Area (BA) 45/47 and more posterior dorsal BA 44, increase activity on trial-by-trial...
Functional magnetic resonance imaging (fMRI) based on blood oxygen level-dependent (BOLD) contrast has become an increasingly popular technique for mapping the brain. The relationship between BOLD-fMRI and of flow activation with positron emission tomography (PET) remains unclear. Moreover, BOLD strategies analysis procedures vary widely across laboratories. To examine these different methods, we compared brain maps a word-stem completion task obtained both using PET fMRI two separate...
Objective: The infant temperament behavioral inhibition is a potent risk factor for development of an anxiety disorder. It difficult to predict at birth, however, and the neural underpinnings are poorly understood. authors hypothesized that neonatal functional connectivity ventral attention network related age 2 years beyond sociodemographic familial factors. This hypothesis supported by network's role in novelty, key feature inhibition. Method: Using longitudinal design (N=45), measured...
Abstract Event-related fMRI studies reveal that episodic memory retrieval modulates lateral and medial parietal cortices, dorsal middle frontal gyrus (MFG), anterior PFC. These regions respond more for recognized old than correctly rejected new words, suggesting a neural correlate of success. Despite significant efforts examining success regions, their role in remains largely unknown. Here we asked the question, to what degree are performing memory-specific operations? And if so, they all...
A bstract : Cerebellar data from five experiments using different groups of subjects performing the same motor learning task are presented. Positron emission tomography (PET) as well functional magnetic resonance imaging (fMRI) was used to study changes in cerebellar activations an effect learning. brain obtained during performance a new were compared after practice. To account for velocity and somatosensory processing practice, two control conditions included. Behavioral showed that...
Theories of brain-network organization based on neuroimaging data have burgeoned in recent years, but the predictive power such theories for cognition and behavior has only rarely been examined. Here, predictions from clinical neuropsychologists about cognitive profiles patients with focal brain lesions were used to evaluate a theory (Warren et al., 2014). Neuropsychologists made regarding neuropsychological neurological patient sample (N = 30) lesion location. The then rated congruence...