A5036455379- Obsessive-Compulsive Spectrum Disorders
- Zebrafish Biomedical Research Applications
- Cell Image Analysis Techniques
- Spinal Cord Injury Research
- Plant Disease Resistance and Genetics
- Gut microbiota and health
- Neurogenesis and neuroplasticity mechanisms
- Chromosomal and Genetic Variations
- Rangeland and Wildlife Management
- Genomics and Phylogenetic Studies
- Nuclear Receptors and Signaling
- Alzheimer's disease research and treatments
- Fish Ecology and Management Studies
- Migraine and Headache Studies
- Biomedical Text Mining and Ontologies
- Advanced MRI Techniques and Applications
- Malaria Research and Control
- RNA Research and Splicing
- Pluripotent Stem Cells Research
- Food composition and properties
- Endoplasmic Reticulum Stress and Disease
- Neurobiology and Insect Physiology Research
- Diet and metabolism studies
- Synthesis and Catalytic Reactions
- Breastfeeding Practices and Influences
University of California, Davis
2023-2024
Washington University in St. Louis
2018-2023
University of Pennsylvania
2022
Rancho Santa Ana Botanic Garden
2020
California Native Plant Society
2020
Institute for Neurodegenerative Disorders
2017
Brigham Young University
2016
St. Jude Children's Research Hospital
2012
University of Wisconsin–Stevens Point
2008
Mutations in leucine-rich repeat kinase 2 (LRRK2) are associated with increased risk for developing Parkinson's disease (PD). Previously, we found that LRRK2 G2019S mutation carriers have mitochondrial DNA (mtDNA) damage and after zinc finger nuclease-mediated gene correction, mtDNA was no longer detectable. While the phenotype can be unambiguously attributed to mutation, underlying mechanism(s) is unknown. Here, examine role of function G2019S-mediated damage, using both genetic...
ABSTRACT Members of the mammalian gut microbiota metabolize diverse complex carbohydrates that are not digested by host, which collectively labeled “dietary fiber.” While enzymes and transporters each strain uses to establish a nutrient niche in often exquisitely specific, relationship between carbohydrate structure microbial ecology is imperfectly understood. The present study takes advantage recent advances determination test effects fiber monosaccharide composition on fermentation....
Gene duplication plays a central role in adaptation to novel environments by providing new genetic material for functional divergence and evolution of biological complexity. Several evolutionary models have been proposed gene explain how copies are preserved natural selection, but these rarely tested using empirical data. Opsin proteins, when combined with chromophore, form photopigment that is responsible the absorption light, first step phototransduction cascade. Adaptive duplications...
Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal maintenance and application embryonic stem cells (ESCs). While protein-protein interactions core factors have been identified in mouse ESCs, their interactome human ESCs (hESCs) has not to date explored. Here we mapped OCT4 interactomes naïve primed hESCs, revealing extensive connections mammalian ATP-dependent nucleosome remodeling complexes. In associated with both BRG1 BRM, two paralog ATPases BAF...
Accurate detection of homologous relationships biological sequences (DNA or amino acid) amongst organisms is an important and often difficult task that essential to various evolutionary studies, ranging from building phylogenies predicting functional gene annotations. There are many existing heuristic tools, most commonly based on bidirectional BLAST searches used identify genes combine them into two fundamentally distinct classes: orthologs paralogs. Due only using filtering significance...
Necrotizing enterocolitis (NEC) is the leading cause of death caused by gastrointestinal disease in preterm infants. Major risk factors include prematurity, formula feeding, and gut microbial colonization. Microbes have been linked to NEC, yet there no evidence causal species, select probiotics shown reduce NEC incidence In this study, we evaluated effect probiotic Bifidobacterium longum subsp. infantis (BL. infantis), alone combination with a human milk oligosaccharide (HMO)—sialylactose...
Due to their renowned regenerative capacity, adult zebrafish are a premier vertebrate model interrogate mechanisms of innate spinal cord regeneration. Following complete transection cord, extend glial and axonal bridges across severed tissue, regenerate neurons proximal the lesion, regain swim capacities within 8 weeks injury. Recovery function is thus central readout for functional repair. Here, we describe set behavioral assays quantify motor capacity inside an enclosed tunnel. The goal...
Many transposable elements (TEs) contain transcription factor binding sites and are implicated as potential regulatory elements. However, TEs rarely functionally tested for activity, which in turn limits our understanding of how TE activity has evolved. We systematically the human LTR18A subfamily using massively parallel reporter assay (MPRA) found AP-1- CEBP-related motifs drivers enhancer activity. Functional analysis evolutionarily reconstructed ancestral sequences revealed that have...
Adult zebrafish are capable of anatomical and functional recovery following severe spinal cord injury. Axon growth, glial bridging adult neurogenesis hallmarks cellular regeneration during repair. However, the correlation between these regenerative processes remains to be elucidated. Whereas majority established metrics measure swim capacity, we hypothesize that gait quality is more directly related neurological health. Here, performed a longitudinal tracking study for 60 individual spanning...
Tics manifest as brief, purposeless and unintentional movements or noises that, for many individuals, can be suppressed temporarily with effort. Previous work has hypothesized that the chaotic temporal nature of tics could possess an inherent fractality, is, have neighbour-to-neighbour correlation at all levels timescale. However, demonstrating this phenomenon eluded researchers more than two decades, primarily because challenges associated estimating scale-invariant, power law...
Abstract Background and study aims The majority of patients with 10 or more cumulative colorectal adenomas have uninformative genetic testing meet criteria for colonic adenomatous polyposis unknown etiology (CPUE). yield upper gastrointestinal screening in CPUE after multi-gene panel is our objective was to characterize this. Patient methods A multicenter, retrospective analysis endoscopies adults performed. Those a history gastroduodenal neoplasia prior diagnosis were excluded. Demographic...
Abstract Summary Detecting homologous sequences in organisms is an essential step protein structure and function prediction, gene annotation phylogenetic tree construction. Heuristic methods are often employed for quality control of putative homology clusters. These heuristics, however, usually only apply to pairwise sequence comparison do not examine clusters as a whole. We present the Orthology Group Cleaner (the OGCleaner), tool designed filtering orthology groups or non-homology by...
Eastern white pine ( Pinus strobus L.) forests are considered fire dependent, but little is known about the role of low-intensity fires. We conducted four prescribed burns to examine understory effects. The vegetation was sampled one year before and two consecutive years after burns. Understory metrics were calculated for vernal (May–June) aestival (mid-August) assemblages. fires resulted in a cumulative mortality rate sapling layer 64%. During first year, had neutral or repressive effect on...
Due to their renowned regenerative capacity, adult zebrafish are a premier vertebrate model interrogate mechanisms of innate spinal cord regeneration. Following complete transection cord, extend glial and axonal bridges across severed tissue, regenerate neurons proximal the lesion, regain swim capacities within 8 weeks injury. Recovery function is thus central readout for functional repair. Here, we describe set behavioral assays quantify motor capacity inside an enclosed tunnel. The goal...
In a double blind prospective study of side effects to cervical myelography 38 patients were evaluated with neurologic examination, electroencephalography (EEG), brainstem evoked response (BER), somatosensory responses (SSER), and continuous reaction times prior at 6 h 24 after either metrizamide or iohexol. A difference in the incidence (for example headache, dizziness, nausea, neck pain) two different contrast media indicated that inconveniences related not only due spinal puncture. medium...
Abstract Many transposable elements (TEs) contain transcription factor binding sites and are implicated as potential regulatory elements. However, TEs rarely functionally tested for activity, which in turn limits our understanding of how TE activity has evolved. We systematically the human LTR18A subfamily using massively parallel reporter assay (MPRA) found AP-1 C/EBP-related motifs drivers enhancer activity. Functional analysis evolutionarily reconstructed ancestral sequences revealed that...
Abstract Tics manifest as brief, purposeless, and unintentional movements or noises that, for many individuals, can be suppressed temporarily with effort. Peterson Leckman (1998) hypothesized that the chaotic temporal nature of tics could possess an inherent fractality, is, have neighbor-to-neighbor correlation at all levels time scale. However, demonstrating this phenomenon has eluded researchers more than two decades, primarily because challenges associated estimating scale-invariant,...
Adult zebrafish are capable of anatomical and functional recovery following severe spinal cord injury. Axon growth, glial bridging adult neurogenesis hallmarks cellular regeneration during repair. However, the correlation between these regenerative processes remains to be elucidated. Whereas majority established metrics measure swim capacity, we hypothesize that gait quality is more directly related neurological health. Here, performed a longitudinal tracking study for sixty individual...