A5102743986- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Ferroptosis and cancer prognosis
- Adipose Tissue and Metabolism
- Parasites and Host Interactions
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Vitamin D Research Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Drug Transport and Resistance Mechanisms
- Sodium Intake and Health
- Science, Research, and Medicine
- Cerebrovascular and genetic disorders
- Dialysis and Renal Disease Management
- Lipoproteins and Cardiovascular Health
- Metabolism, Diabetes, and Cancer
- Vitamin C and Antioxidants Research
- GDF15 and Related Biomarkers
- RNA modifications and cancer
- Pineapple and bromelain studies
- Nuclear Receptors and Signaling
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin K Research Studies
Second Xiangya Hospital of Central South University
2010-2025
Central South University
2010-2025
Background The relationship between monocyte-to-lymphocyte ratio (MLR) and prognosis in patients with chronic kidney disease (CKD) remains unclear. aim of this study was to investigate the association MLR both all-cause mortality cardiovascular (CVD) CKD.
Ionic perturbation in vascular smooth muscle cells contributes to cerebrovascular remodelling the setting of hypertension, but role transient receptor potential (TRP) channel superfamily remains unknown. The present study was conducted define contribution TRP channels remodelling.By integrating quantitative PCR, western blotting, patch clamping, and Ca(2+) imaging, we identified channel, subfamily canonical, member 3 (TRPC3) as subtype most considerably elevated basilar arteries two-kidney,...
Non-alcoholic fatty liver disease (NAFLD) is currently the major cause of chronic globally. Bile acids (BAs) have emerged as relevant signaling molecules that are associated with NAFLD development. This study was aimed to examine association serum total bile (TBAs) in a large population Chinese subjects.This cross sectional recruited 152,336 participants from Second Xiangya Hospital, China. diagnosed based on presence hepatic steatosis ultrasonography, without significant alcohol consumption...
Background Metabolic dysfunction-associated steatohepatitis (MASH) is a highly prevalent liver disease globally, with significant risk of progressing to cirrhosis and even cancer. Efferocytosis, process implicated in broad spectrum chronic inflammatory disorders, has been reported be associated the pathogenesis MASH; however, its precise role remains obscure. Thus, we aimed identify validate efferocytosis linked signatures for detection MASH. Methods We retrieved gene expression patterns...
Background: Ferroptosis is a novel type of programmed cell death characterized by excessive lipid peroxides and iron overload inside the cell. SLC7A11/GSH one most important anti-ferroptotic pathways. Macrophage ferroptosis contributes to progression atherosclerosis. HDL exerts anti-atherosclerotic effects primarily promoting cholesterol efflux. Whether also inhibits macrophage unknown. Research Questions: This research was aimed explore mechanisms on ferroptosis. Methods: detected in...