A5101586142- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Inflammasome and immune disorders
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Acute Ischemic Stroke Management
- Cardiac Structural Anomalies and Repair
- Gout, Hyperuricemia, Uric Acid
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Bioactive natural compounds
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Atherosclerosis and Cardiovascular Diseases
- Nuclear Receptors and Signaling
- Cytokine Signaling Pathways and Interactions
- Cardiac Arrhythmias and Treatments
- Peripheral Artery Disease Management
- Pharmaceutical Economics and Policy
- Pregnancy-related medical research
Anhui Medical University
2016-2025
Second Hospital of Anhui Medical University
2016-2025
Jiangsu Hengrui Medicine (China)
2024
Anhui Provincial Hospital
2019
The NOD–like receptor pyrin domain–containing protein 3 (NLRP3) inflammasome activation–mediated pyroptosis pathway has been linked to myocardial ischemia–reperfusion (MI/R) injury. This study explored whether uric acid (UA) aggravates MI/R injury through NLRP3 inflammasome–mediated pyroptosis. In vivo, a mouse model was established by ligating the left coronary artery, and hyperuricemia created intraperitoneal injection of potassium oxonate (PO). Then, infarction (MI) size; terminal...
Neutrophil to lymphocyte ratio (NLR) and platelet (PLR) are inflammatory markers used for prediction of chronic complications diabetes. Lower extremity arterial disease (LEAD) is one type 2 diabetes mellitus (T2DM). The correlation between NLR, PLR, lower vascular lesions was investigated in subjects with T2DM determine the best predictive marker LEAD.Three hundred thirty-five patients (199 males 136 females; age 54.12 ± 14.07 years) were enrolled. Blood differential counts anklebrachial...
Abstract Background Recaticimab (SHR-1209, a humanized monoclonal antibody against PCSK9) showed robust LDL-C reduction in healthy volunteers. This study aimed to further assess the efficacy and safety of recaticimab patients with hypercholesterolemia. Methods In this randomized, double-blind, placebo-controlled phase 1b/2 trial, receiving stable dose atorvastatin an level 2.6 mmol/L or higher were randomized ratio 5:1 subcutaneous injections placebo at different doses schedules. Patients...
This study aimed to prospectively observe the changes in neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) before after percutaneous coronary intervention (PCI) their impact on prognosis of patients with acute syndrome (ACS).Blood samples from 205 ACS were collected at admission 24h 30 days post-PCI complete blood count. The Cox multivariate regression model was used analyze factors influencing major adverse cardiac events (MACE) PCI ACS. A receiver operating...
The present study prospectively investigated the effect of blood glucose level at admission on monocyte chemoattractant protein‑1 levels different time points before and after primary percutaneous coronary intervention, postoperative 1‑year prognosis patients with acute ST‑segment elevation myocardial infarction. 146 infarction undergoing intervention were divided into three groups: Group 1, non‑diabetic, non‑hyperglycemic group; group 2, stress hyperglycemia 3, diabetic group. Serum (PCI),...
To investigate the procedural efficiency, efficacy, and safety of high-power, short-term radiofrequency ablation delivered by SmartTouch Surround Flow (STSF) catheter for paroxysmal atrial fibrillation (AF).We retrospectively analyzed a total 72 patients who were admitted with AF, underwent (RFCA) first time. Of these patients, 36 cases low-power, long-duration (LPLD, (30-35 W/20-40 s) pulmonary vein isolation (PVI) an (ST) (control group), other short-duration (HPSD, (45-50 W/10-20 PVI STSF...
Background: The aim of this study was to investigate the impact body mass index (BMI) and weight on concentrations ticagrelor metabolite, AR-C124910XX, as well platelet aggregation rate (PAR) in a Chinese Han population with unstable angina (UA). Specifically, it focused these parameters following administration dual antiplatelet therapy (DAPT) comprising aspirin ticagrelor. Methods: A total 105 patients UA were included study. Measurement induced by adenosine diphosphate (PAR-ADP) performed...
Abstract The present study was designed to investigate whether 17β-estrogen (E2) reduces myocardial I/R injury by inhibiting NLRP3 inflammasome mediated pyroptosis. In vivo , four-weeks-old female C57BL/6 mice underwent ovariectomy (Ovx) before E2 replacement therapy. After the establishment of injury, plasma E2, LDH and CK-MB were detected, infarction (MI) size, TUNEL immunofluorescence, expressions TXNIP, NLRP3, caspase-1, apoptosis-associated speck-like protein containing a CARD (ASC),...
This meta-analysis explores the efficacy and safety of dual antithrombotic treatment (DAT); novel oral anticoagulants (NOAC)-based triple therapy (TAT); vitamin K antagonist (VKA)-based TAT in patients with AF undergoing PCI. Relevant studies listed English PubMed, Google Scholar, Cochrane Library, or ClinicalTrials.gov were identified. We used a random effects model to calculate odds ratios (OR) 95% confidence intervals (CI). Endpoints included all bleeding events, intracranial hemorrhage,...