A5023014310- S100 Proteins and Annexins
- Protease and Inhibitor Mechanisms
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Blood Coagulation and Thrombosis Mechanisms
- Peptidase Inhibition and Analysis
- Helicobacter pylori-related gastroenterology studies
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- Galectins and Cancer Biology
- Pregnancy and preeclampsia studies
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- SARS-CoV-2 and COVID-19 Research
- Diabetic Foot Ulcer Assessment and Management
- Veterinary medicine and infectious diseases
- Thyroid Cancer Diagnosis and Treatment
- Reproductive Biology and Fertility
- Cytokine Signaling Pathways and Interactions
- Click Chemistry and Applications
- RNA Research and Splicing
- Signaling Pathways in Disease
- Plant Pathogenic Bacteria Studies
- RNA modifications and cancer
- Ginger and Zingiberaceae research
K S Hegde Medical Academy
2019-2024
Nitte University
2019-2024
Creative Commons
2022
Central Food Technological Research Institute
2021
Bangalore University
2021
University of Aveiro
2021
Imperial College Healthcare NHS Trust
2020
SDM College of Medical Science and Hospital
2011-2019
University of North Texas
2010-2015
University of North Texas Health Science Center
2010-2015
Alternative survival pathways are commonly seen to be upregulated upon inhibition of receptor tyrosine kinases (RTK), including Her-2. It is established that treatment with Herceptin leads selective overexpression and activation epidermal growth factor (EGFR) Src which further contributes oncogenesis in resistant triple negative breast cancer (TNBC) patients. Here, we show a co-regulated upregulation the expression Annexin A2 (AnxA2), known substrate one regulators EGFR endocytosis, Her-2...
Migration and invasion enhancer 1 (MIEN1) is a novel gene found to be abundantly expressed in breast tumor tissues functions as critical regulator of cell migration promote systemic metastases. Previous studies have identified post-translational modifications by isoprenylation at the C-terminal tail MIEN1 favor its translocation inner leaflet plasma membrane function membrane-bound adapter molecule. However, exact molecular events interface activating MIEN1-driven motility are vaguely...
Abstract The Tumor suppressor SMAR1 (scaffold matrix attachment region binding protein 1) has a crucial role in maintaining genomic stability, cell cycle progression and apoptosis.Our previous finding showed that it is highly suppressed higher grade of cancer. However, the underlying mechanism this suppression was not well understood. In study, we show expression levels are controlled at proteasomal level by five RING finger E3 ubiquitin ligases including, Cdc20, substrate receptor ligase...
H1299 lung carcinoma cells lacking p53 (p53-/-) express minimal amounts of plasminogen activator inhibitor-1 (PAI-1) protein as well mRNA. p53(-/-) highly unstable PAI-1 Transfection in enhanced expression and stabilized On the contrary, inhibition by RNA silencing non-malignant human epithelial (Beas2B) decreased basal urokinase-type activator-induced because accelerated degradation Purified specifically binds to mRNA 3'-un-translated region (UTR), endogenous forms an immune complex with...
Annexin A2 (AnxA2) is a multifunctional Ca(2+)-dependent phospholipid-binding protein, and its overexpression implicated in malignant transformation of several cancers. In prostate cancer, however, the expression AnxA2 lost intraepithelial neoplasia reappears high-grade tumors, suggesting complex regulation microenvironment. Since majority biological functions are mediated by interaction with other proteins, we performed yeast two-hybrid assay to search for novel interactors AnxA2. Our...
The transformation of a normal cell to cancer requires the derail multiple pathways. Normal signaling in is regulated at stages by presence feedback loops, calibration levels proteins their turnover, and posttranscriptional regulation, name few. tumor suppressor protein FBXO31 component SCF E3 ubiquitin ligase required arrest cells G1 following genotoxic stresses. Due its growth-suppression activity, it underexpressed many cancers. However, molecular mechanism underlying translational...
<ns4:p>Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, is associated with hyperinflammation cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, being used manage storm in patients. However, extensive use corticosteroids leads serious adverse events disruption gut-lung axis. Various...
We found that p53-deficient (p53−/−) lung carcinoma (H1299) cells express robust levels of cell surface uPAR and mRNA. Expression p53 protein in p53−/− suppressed basal urokinase (uPA)-induced increased mRNA degradation. Inhibition by RNA silencing Beas2B human airway epithelial conversely as well uPA-mediated expression stabilized Purified specifically binds to the 3′ untranslated region (3′UTR), endogenous associates with p53. The binding involves a 37-nucleotide 3′UTR sequence, insertion...
Urokinase-type plasminogen activator (uPA) receptor (uPAR) is required for the recruitment of neutrophils in response to infection. uPA induces its own expression lung epithelial cells, which involves interaction with cell surface uPAR. Regulation uPAR therefore crucial uPA-mediated signaling infectious acute injury (ALI).
Purpose The integration of large-scale gene data and their functional analysis needs the effective application various computational tools. Here we attempted to unravel biological processes cellular pathways in response ionizing radiation using a systems biology approach. Materials Methods Analysis ontology shows that 80, 42, 25, 35 genes have roles process, molecular function, immune system pathways, respectively. Therefore, our study emphasizes gene/protein network on differentially...
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Interaction of urokinase-type plasminogen activator (uPA) with its receptor, uPAR, is a key regulatory step in uPA-mediated cell proliferation and migration. Our previous studies demonstrated that posttranscriptional stabilization uPAR mRNA by uPA contributes to the induction surface expression, heterogeneous nuclear ribonuclear protein C1 (hnRNPC) binds 110 nt sequence 3'-UTR, thereby preventing degradation. These observations indicate hnRNPC could be involved expression uPA. In present...
Rationale: Urokinase-type plasminogen activator (uPA) regulates extracellular proteolysis in lung injury and repair. Although alveolar expression of uPA increases, procoagulant activity predominates.Objectives: This study was designed to investigate whether alters the tissue factor (TF), major initiator coagulation cascade, epithelial cells (ECs).Methods: Bronchial, primary airway ECs C57B6 wild-type, uPA-deficient (uPA−/−) mice were exposed phosphate-buffered saline, uPA, or LPS....
Background AnnexinA2 (AnxA2) membrane deposition has a critical role in HB-EGF shedding as well IL-6 secretion breast cancer cells. This autocrine cycle major cell proliferation, migration and metastasis. The objective of the study is to demonstrate annexinA2-mediated regulation via Her-2 negative progression. Methods Secretory annexinA2, were analysed peripheral blood sample ( n = 20) positive patients 16). Simultaneously, tissue expression was by immunohistochemistry. these secretory...
Apoptosis is a programmed cell death that efficiently removes damaged cells to maintain tissue homeostasis. Defect in apoptotic machinery can lead tumor development, progression, and resistance chemotherapy. PUMA (p53 upregulated modulator of apoptosis) BAX (BCL2-associated X protein) are among the most well-known inducers apoptosis. It has been reported expression levels controlled at posttranslational level by phosphorylation. However, regulation these proapoptotic proteins remains largely...
Aim: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis mainly affecting articular and extraarticular structures. AS clinical manifestations also involve sacroiliac joints spine. Genetic factors play key role in susceptibility. AS-associated subtypes of human leukocyte antigen (HLA)-B27 other HLA-B alleles vary different ethnic populations. There are no reports HLA B genotype association to South Indian patients. In the current study, we have analyzed with 105 patients 100...
ERIC, the Enteropathogen Resource Integration Center (www.ericbrc.org), is a new web portal serving as rich source of information about enterobacteria on NIAID established list Select Agents related to biodefense-diarrheagenic Escherichia coli, Shigella spp., Salmonella Yersinia enterocolitica and pestis. More than 30 genomes have been completely sequenced, many more exist in draft form additional projects are underway. These organisms increasingly focus studies using high-throughput...