A5102867462- Infant Nutrition and Health
- Reproductive Biology and Fertility
- Nutritional Studies and Diet
- Neonatal Health and Biochemistry
- Epigenetics and DNA Methylation
- Obesity, Physical Activity, Diet
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Neonatal Respiratory Health Research
- Insect Resistance and Genetics
- Supramolecular Self-Assembly in Materials
- Nanoplatforms for cancer theranostics
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Folate and B Vitamins Research
- Breastfeeding Practices and Influences
- Renal and related cancers
- Prenatal Screening and Diagnostics
- CRISPR and Genetic Engineering
- Genetically Modified Organisms Research
- RNA Research and Splicing
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- Genetic Syndromes and Imprinting
- Molecular Biology Techniques and Applications
Peking University Third Hospital
2020-2025
Peking University
2012-2025
Peking University People's Hospital
2015-2024
Sichuan Normal University
2024
Ministry of Education of the People's Republic of China
2020
Abstract The spermatogenesis process is complex and delicate, any error in a step may cause arrest even male infertility. According to our previous transcriptomic data, CEP70 highly expressed throughout various stages of human spermatogenesis, especially during the meiosis deformation stages. present sperm tails that it exists centrosomes as revealed by centrosome proteomics. However, specific mechanism this protein still unknown. In study, we found heterozygous site same mutation on through...
To observe the effect of prolonged feeding dietary nucleotides (NTs), and to clarify NTs on life extension Sprague-Dawley rats. There were 50 rats in each group (male:female ratio=1:1), which fed diets supplemented with at concentrations 0%, 0.01%, 0.04%, 0.16% 0.64% (wt/wt) from age 4 weeks until natural death. We investigated moribundity mortality, survival time, spontaneous tumor incidence, serum oxidative status. have significantly influence body weight first 3 month old food consumption...
Carbohydrates play an important role in blood glucose control pregnant women with GDM. Carbohydrate-restricted dietary (CRD) pattern for gestational diabetes mellitus (GDM) has been widely used clinics, but the change insulin utilization rate beyond CRD intervention GDM remains unclear. The aim of present study was to explore application pregnancy GDM, as well influence on lipid metabolism and nutritional state. A retrospective 265 who delivered Peking University People’s Hospital from July...
Saussurea involucrata (SI) has long been used under the herbal name "snow lotus" for treatment of inflammation and pain-related diseases in traditional Chinese medicine. The present study aimed to evaluate pharmacological effects SI on collagen II (CII)-induced arthritis rats. Rats with were orally administered (420 mg kg(-1)) 40 consecutive days. Histopathological examination indicated that alleviates infiltration inflammatory cells synovial hyperplasia slows joint destruction. intervention...
BT799 is a genetically modified (GM) maize plant that expresses the Cry1Ac gene from Bacillus thuringiensis (Bt). The was introduced into line Zhen58 to encode Bt crystal protein and thus produce insect-resistant BT799. Expression of in planta confers resistance Lepidopteran pests corn rootworms. present study designed investigate any potential effects on reproductive system male rats evaluate nutritional value diets containing grain 90-day subchronic rodent feeding study. Male Wistar were...
Diabetes mellitus is very common in elderly Chinese individuals. Although nutritional intervention can provide a balanced diet, the sustaining effect on at-home dietary behavior and long-term plasma glucose control not clear. Consequently, we conducted survey following one month of experiential combined with health education. Based Dietary Guidelines for Resident, found that food items met recommended values, percentages energy provided from fat, protein, carbohydrate were more reasonable...
In this paper, microbiota analysis was determined to analyze the structure and difference of intestinal between LBMJ (late-onset breast milk jaundice) infants healthy individuals.We collected fresh fecal samples from 13 with individuals, then by 16 s rRNA sequencing. The differences structure, diversity functional characteristics two groups were analyzed, correlation dominant genus TcB (transcutaneous bilirubin) value calculated.In study, there no significant in maternal demographic...
Is it possible to evaluate the methylome of individual oocytes investigate DNA alterations in metaphase II (MII) with reduced embryo developmental potential?The each human first polar body (PB1) closely mirrored that its sibling MII oocyte; hypermethylated long interspersed nuclear element (LINE) and terminal repeats (LTRs) methylation aberrations PB1 promoter regions may indicate poor development.The potential an is determined by oocyte's competence, a good substitute examine chromosomal...
Breast milk is crucial in the development of late-onset breast jaundice (BMJ), possibly due to composition and lactating mother’s diet. To explore possible nutritional pathogenesis BMJ, we investigated lactation diet collected by following 42-day postpartum mother−infants pairs Beijing a total 94 were enrolled. The macronutrient content was measured, epidermal growth factor (EGF) determined ELISA. Data on in-hospital out-of-hospital breastfeeding, infant growth, jaundice-related vaccination,...
Multi-responsive drug-delivery systems have been widely explored to enable specific delivery target sites. Here, Interleukin-4 (IL-4), an anti-inflammatory cytokine, is first encapsulated in situ inside a zeolitic imidazolate framework (ZIF-8) form IL-4@ZIF-8, which subsequently coated with diselenide block copolymer obtain IL-4@ZIF-8@Se-Se-polymer. This system enables redox-responsive release of IL-4 by the and pH-triggered ZIF-8. Moreover, precisely controlled stepwise stumuli response,...
Background: Late-onset breast milk jaundice (LBMJ) is a common form of hyperbilirubinemia, which can result in serious complications for newborns with persistently high bilirubin levels. The aim this study was to investigate the differences fecal metabolites between breastfed infants and without LBMJ order elucidate potential biological mechanisms. Methods: Biological samples were collected from 12 healthy individuals. Ultra-high performance liquid chromatography quadrupole time-of-flight...
Abstract Breast milk leptin plays a potential role in preventing childhood obesity. However, the associations of breast with maternal metabolism pregnancy and dietary patterns during lactation are still unclear. We aimed to explore metabolic profiles lactation. A total 332 participants were recruited for this retrospective cohort study. samples collected at approximately 6 weeks postpartum. twenty-three measured semi-quantitative FFQ was used gather information Both principal component...
TT51, with a synthetic Cry1Ab/CryAc gene from Bacillus thuringiensis Berliner, was the first genetically modified (GM) plant officially certificated in China. This study undertaken to investigate potential embryotoxicity of TT51 on rats. Whole embryo culture (WEC) is an effective method for safety evaluation when medium, containing substances derived GM food, available. Rat embryos explanted uterus were randomly distributed into 6 groups: Transgenic Rice (TR) group transgenic rice dietary...
To assess the long-term toxicity and carcinogenicity of dietary nucleotides (NTs), Sprague-Dawley rats were administered NTs for life-through with dose 0, 0.01%, 0.04%, 0.16% 0.64%. With exception several groups, results showed no significant differences in weight gain, clinical symptoms data, blood indicators, Non-neoplastic lesions frequencies. have dramatically increased food consumption both sexes (P<0.05). Meanwhile, decreased spontaneous tumor incidence sexes, notably male The...
Objective: To explore the status of glucocorticoid application in patients with systemic lupus erythematosus (SLE) China. Methods: Epidemiological survey was used. The SLE who met 1997 classification criteria American College Rheumatology were enrolled. usage and related adverse reactions recorded analyzed. Results: A total 400 enrolled, including 35 men 365 women. average age (37.4±14.0) years old, duration disease (6.7±5.8) years. There 310 using as maintenance. Sixty-one percent (n=244)...