A5025501813- Cellular Mechanics and Interactions
- Collagen: Extraction and Characterization
- 3D Printing in Biomedical Research
- Microtubule and mitosis dynamics
- Developmental Biology and Gene Regulation
- Neurobiology and Insect Physiology Research
- Pluripotent Stem Cells Research
- Ubiquitin and proteasome pathways
- Micro and Nano Robotics
- CRISPR and Genetic Engineering
- Congenital heart defects research
- Gastrointestinal motility and disorders
- Genomics and Chromatin Dynamics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Muscle Physiology and Disorders
- Tendon Structure and Treatment
- Kruppel-like factors research
- Congenital gastrointestinal and neural anomalies
- Invertebrate Immune Response Mechanisms
- Spaceflight effects on biology
Université Paris Sciences et Lettres
2020-2023
Délégation Ile-de-France Villejuif
2023
Institut Curie
2020-2023
Centre National de la Recherche Scientifique
2004-2022
Laboratoire Matière et Systèmes Complexes
2019
Université Paris Cité
2019
Sorbonne Paris Cité
2019
Inserm
2004-2009
Université de Strasbourg
2009
Institut de génétique et de biologie moléculaire et cellulaire
2004-2007
Neurogenic gut movements start after longitudinal smooth muscle differentiation in three species (mouse, zebrafish, chicken), and at E16 the chicken embryo. The first activity of enteric nervous system is dominated by inhibitory neurons. embryonic electromechanically couples circular spontaneous myogenic contractions, thereby producing a new, rostro-caudally directed bolus transport pattern: migrating motor complex. response to mechanical stimulation evolves from symmetric, E12, neurally...
Although glial cells missing (gcm) genes are known as determinants in the fly embryo, role of vertebrate orthologs central nervous system is still under debate. Here we show for first time that chicken ortholog gcm (herein referred to c-Gcm1), expressed early neuronal lineages developing spinal cord and required neural progenitors differentiate neurons. Moreover, c-Gcm1 overexpression sufficient trigger cell cycle exit differentiation progenitors. Thus, expression constitutes a crucial step...
Gliogenesis in animal development is spatiotemporally regulated so that correct numbers of glia are present to support various neuronal functions. During Drosophila embryonic development, the glial regulatory gene, cell missing/glial deficient ( gcm/glide ), promotes fate and differentiation. Here we describe ubiquitin–proteasome regulation Gcm protein consequence gliogenesis without timely degradation Gcm. binds 2 F-box proteins, Supernumerary limbs (Slimb) Archipelago (Ago), adaptors SCF...
Glial cell deficient/Glial cells missing (Glide/Gcm) transcription factor is expressed in all glial precursors of the Drosophila embryo. Gcm necessary and sufficient to induce differentiation but also plays a role other types, by interacting with specific factors. To find potential partners which trigger these pathways, we performed yeast two-hybrid screen identified dpias, gene involved post-embryonic hematopoiesis. dpias larvae show melanotic tumors due excess lamellocytes, hemocyte...
Locomotion relies on stable attachment of muscle fibres to their target sites, a process that allows for contraction generate movement. Here, we show glide/gcm and glide2/gcm2, the fly glial cell determinants, are expressed in subpopulation embryonic tendon cells required terminal differentiation. By using loss-of-function approaches, absence both genes, is altered, even though molecular cascade induced by stripe, determinant, normal. Moreover, activates new gene independently stripe....
Abstract In the initial cancer stages, cancer-associated fibroblasts (CAFs) create a capsule around tumors. Exhibiting an elongated morphology, CAFs align with each other, closely resembling nematic ordering in liquid crystal physics. While these aligned may act as defensive barrier hindering tumor expansion, inherent topological defects could represent weak spots, facilitating cell dissemination. play pivotal role genesis and remodeling of extracellular matrix (ECM), ECM proteins,...
Abstract There is growing evidence that the physical properties of cellular environment can impact cell migration. However, it not currently understood how active remodeling network by cells affects their migration dynamics. Here, we study collective small clusters on deformable collagen-1 networks. Combining theory and experiments, find clusters, despite displaying no apparent internal polarity, migrate persistently generate asymmetric collagen gradients during We persistent arise from...