A5050576296- Dialysis and Renal Disease Management
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Renal Transplantation Outcomes and Treatments
- Family Caregiving in Mental Illness
- Cellular transport and secretion
- Obstructive Sleep Apnea Research
- Chronic Disease Management Strategies
- Cancer survivorship and care
- Palliative Care and End-of-Life Issues
- Organ Donation and Transplantation
- Ultrasound in Clinical Applications
- Biomedical Text Mining and Ontologies
- Health Systems, Economic Evaluations, Quality of Life
- Sleep and related disorders
- Innovations in Medical Education
- Cutaneous Melanoma Detection and Management
- Gut microbiota and health
- Intensive Care Unit Cognitive Disorders
- Bipolar Disorder and Treatment
- Nonmelanoma Skin Cancer Studies
- Genetic Associations and Epidemiology
- Infectious Diseases and Mycology
- Mobile Health and mHealth Applications
- Medication Adherence and Compliance
University of Toronto
2017-2024
Toronto Metropolitan University
2019-2023
University Health Network
2017-2023
Toronto Western Hospital
2023
Women's College Hospital
2021-2022
SKiN Health
2022
Princess Margaret Hospital
2021
Health Net
2021
McGill University
2021
Toronto General Hospital
2018
A preference-based health utility score (PROPr) can be calculated using Patient-Reported Outcomes Measurement Information System domain scores. We assessed the construct validity of PROPr among patients treated with KRT (hemodialysis or kidney transplant).We performed a secondary analysis data collected in multicenter, cross-sectional studies adults KRT, recruited between April 2016 to March 2020 Toronto, Canada. All participants provided informed consent. The outcome was score....
Collecting patient reported outcome measures (PROMs) via computer-based electronic data capture system may improve feasibility and facilitate implementation in clinical care. We report our initial experience about the acceptability of touch-screen tablet computer-based, self-administered questionnaires among patients with chronic kidney disease (CKD), including stage 5 CKD treated renal replacement therapies (RRT) (either dialysis or transplant).We enrolled a convenience sample 4 (including...
Keratinocyte carcinoma is the most common malignant disease, but it not captured in major registries. We aimed to describe differences by sex incidence and mortality rates of keratinocyte Ontario, Canada.We conducted a population-based retrospective study adults residing Ontario between Jan. 1, 1998, Dec. 31, 2017, using linked health administrative databases. identified first diagnosis validated algorithm insurance claims, deaths related from death certificates. calculated carcinoma,...
Butris, Nina BSc; Tang, Evan RN, BSN; He, David MD, PhD, FRCPC; Wang, Dong-Xin PhD; Chung, Frances MBBS, FRCPC Author Information
Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number size depends on balanced fusion fission rates. Thus, conditions favour over can reduce lysosome numbers while enlarging their size. Conversely, favouring may cause fragmentation increase numbers. PIKfyve is a phosphoinositide kinase generates phosphatidylinositol-3,5-bisphosphate to modulate lysosomal...
Abstract Recent studies have uncovered a strong effect of host genetic variation on the composition host-associated microbiota. Here, we present HOMINID, computational approach based Lasso linear regression, that given and microbiome taxonomic data, identifies single nucleotide polymorphisms (SNPs) are correlated with microbial taxa abundances. Using simulated show HOMINID has accuracy in identifying associated SNPs performs better compared existing methods. We also can accurately identify...
<p>Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number size depends on balanced fusion fission rates. Thus, conditions favour over can reduce lysosome numbers while enlarging their size. Conversely, favouring may cause fragmentation increase numbers. PIKfyve is a phosphoinositide kinase generates phosphatidylinositol-3,5-bisphosphate to modulate...
Background The Patient Reported Outcomes Measurement Information System (PROMIS) aims to address the lack of generalizable and universal measure patient reported outcomes assess many health-related quality life domains. It has undergone extensive psychometric testing for validity reliability but it not been tested among patients with chronic kidney disease. Here, we validate PROMIS-57 PROMIS-29, questionnaire transplant recipients. Methods A cross-sectional, convenience sample stable...
Abstract Background Due to the increasing public acceptance of substance use, it is important understand association between use and access kidney transplant its outcomes. Here, we assess sociodemographic predictors KT access. Methods Predictors were examined using a multivariable‐adjusted multinomial logistic regression. The current (tobacco drug) time from referral listing or receipt was Cox proportional hazards models. Results Of 2346 patients, prevalence 17%. tobacco younger age, male...
Abstract Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number size depends on balanced fusion fission rates. Thus, conditions favour over can reduce lysosome numbers while enlarging their size. Conversely, favouring may cause fragmentation increase numbers. PIKfyve is a phosphoinositide kinase generates phosphatidylinositol-3,5-bisphosphate to modulate...
Abstract Recent studies have uncovered a strong effect of host genetic variation on the composition host-associated microbiota. Here, we present HOMINID, computational approach based Lasso linear regression, that given and microbiome data, identifies SNPs are correlated with microbial taxa abundances. Using simulated data show HOMINID has accuracy in identifying associated SNPs, performs better compared to existing methods. We also can accurately identify SNPs. Lastly, by using real human...
Abstract Background The association between cannabis use and access to waitlisting, transplantation, post‐transplant outcomes remains uncertain. Methods Patients referred for kidney transplant (KT) the University Health Network from January 1, 2003, June 30, 2020, followed until December 31, were included. Predictors of reported examined using a logistic regression model. time clearance KT, undergoing was evaluated Cox proportional hazards models. Results Among 3734 patients, prevalence...
Abstract Introduction An important mechanism of research waste is inadequate incorporation of, and references to, previous relevant research. Identifying for a manuscript can be challenging, in part due to the exponential rise potentially literature consider. For large projects, such as developing or updating reporting guidelines, it may helpful construct supportive topic‐specific bibliographic database. Methods In support Standard Protocol Items: Recommendations Interventional Trials...
Implication Statement Point-of-care ultrasound (POCUS) has usually been taught using a hands-on, in-person approach. We present novel approach to delivering POCUS virtually dual image videoconferencing technique. outline an easily implementable and summarize medical students’ experience feedback. This form of delivery potential improve instructional in resource restricted settings or during pandemic restrictions where hands-on may not be possible.