A5068254827- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Genetics, Aging, and Longevity in Model Organisms
- Computational Drug Discovery Methods
- Bioinformatics and Genomic Networks
- Ion channel regulation and function
- Cellular transport and secretion
Abnormal calcium signaling is a central pathological component of Alzheimer's disease (AD). Here, we describe the identification class compounds called ReS19-T, which are able to restore homeostasis in cell-based models tau pathology. Aberrant accumulation leads uncontrolled activation store-operated channels (SOCCs) by remodeling septin filaments at cell cortex. Binding ReS19-T septins restores filament assembly state and restrains entry through SOCCs. In amyloid-β tau-driven mouse disease,...
Neuronal Ca2+ dyshomeostasis and hyperactivity play a central role in Alzheimer's disease pathology progression. Amyloid-beta together with non-genetic risk-factors of contributes to increased influx aberrant neuronal activity, which accelerates neurodegeneration feed-forward fashion. As such, identifying new targets drugs modulate excessive signalling hyperactivity, without overly suppressing them, has promising therapeutic potential.Here we show, using biochemical, electrophysiological,...