A5065828362- Cancer, Hypoxia, and Metabolism
- Alzheimer's disease research and treatments
- Advanced Proteomics Techniques and Applications
- Bioinformatics and Genomic Networks
- Protein Kinase Regulation and GTPase Signaling
- Metabolomics and Mass Spectrometry Studies
- Melanoma and MAPK Pathways
- Prostate Cancer Treatment and Research
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Cells and Metastasis
KU Leuven
2018-2019
Massachusetts Institute of Technology
2018
VIB-KU Leuven Center for Cancer Biology
2018
Abnormal calcium signaling is a central pathological component of Alzheimer's disease (AD). Here, we describe the identification class compounds called ReS19-T, which are able to restore homeostasis in cell-based models tau pathology. Aberrant accumulation leads uncontrolled activation store-operated channels (SOCCs) by remodeling septin filaments at cell cortex. Binding ReS19-T septins restores filament assembly state and restrains entry through SOCCs. In amyloid-β tau-driven mouse disease,...