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Eva Cuveliers

ORCID: 0009-0004-7619-0901
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About
Contact & Profiles
A5023819482
Research Areas
  • Alzheimer's disease research and treatments
  • Click Chemistry and Applications
  • Bioinformatics and Genomic Networks
  • Nuclear Receptors and Signaling
  • Computational Drug Discovery Methods
  • Genetics, Aging, and Longevity in Model Organisms
 Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer’s disease
OPENALEX - Publications 
Katrien Princen Tom Van Dooren Marit van Gorsel Nikolaos Louros Xiaojuan Yang and 40 more Michael Dumbacher I. Bastiaens Kristel Coupet Shana Dupont Eva Cuveliers Annick Lauwers Mohamed Laghmouchi Thomas Vanwelden Sofie Carmans Nele Van Damme Hein Duhamel Seppe Vansteenkiste Jovan Prerad Karolien Pipeleers Olivier Rodiers Liese De Ridder Sofie Claes Yoni Busschots Lentel Pringels Vanessa Verhelst Eveline Debroux Marinka Brouwer Sam Lievens Jan Tavernier Mélissa Farinelli Sandrine Hughes-Asceri Marieke Voets Joris Winderickx Stefaan Wera Joris de Wit Joost Schymkowitz Frédéric Rousseau Henrik Zetterberg Jeffrey L. Cummings Wim Annaert Tom Cornelissen Hans De Winter Koen De Witte Marc Fivaz Gerard Griffioen

Abnormal calcium signaling is a central pathological component of Alzheimer's disease (AD). Here, we describe the identification class compounds called ReS19-T, which are able to restore homeostasis in cell-based models tau pathology. Aberrant accumulation leads uncontrolled activation store-operated channels (SOCCs) by remodeling septin filaments at cell cortex. Binding ReS19-T septins restores filament assembly state and restrains entry through SOCCs. In amyloid-β tau-driven mouse disease,...

10.1126/science.add6260 article EN Science 2024-05-30
 P2.077 First-in-class drugs with neuroprotective potential against Parkinson's disease identifled through biology-driven discovery approach
OPENALEX - Publications 
Tom Van Dooren Kristel Coupet Ellen Gomme Hein Duhamel Annick Lauwers and 8 more Eva Cuveliers Katrien Princen I. Bastiaens Joris Winderickx V. Rojas de la Parra Ilse Van der Auwera Stefaan Wera G. Griffloen

10.1016/s1353-8020(09)70428-6 article EN Parkinsonism & Related Disorders 2009-12-01
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