A5001014785- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Ocular Oncology and Treatments
- PARP inhibition in cancer therapy
University of Duisburg-Essen
2016-2022
Deutschen Konsortium für Translationale Krebsforschung
2021-2022
German Cancer Research Center
2021-2022
Essen University Hospital
2021
Abstract Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion CD8 + T cells is critical for therapy efficacy having anti-proliferative and pro-apoptotic effects on tumour cells. Our study demonstrates a genetic evolution of resistance in different melanoma patient models. Chromosomal alterations subsequent inactivating mutations genes the signalling cascade, most often JAK1 or JAK2, protect from anti-tumour activity. JAK1/2 mutants further evolve into...
Immune checkpoint inhibitors (ICI) are increasingly being used to treat numerous cancer types. Together with improved recognition of toxicities, this has led more frequent identification rare immune-related adverse events (irAE), for which specific treatment strategies needed. Neutropenia is a hematological irAE that potential high mortality rate because its associated risk sepsis. Prompt and timely life-threatening therefore critical the outcome patients neutropenia.This multicenter...
Accurate classification of melanocytic tumors is important for prognostic evaluation, treatment and follow-up protocols patients. The majority proliferations can be classified solely based on clinical pathological criteria, however in select cases a definitive diagnostic assessment remains challenging additional biomarkers would advantageous. We analyzed melanomas, nevi, Spitz nevi atypical spitzoid using parallel sequencing (exons 611 genes 507 gene translocation analysis) methylation...
Around 10% of melanoma occurs in patients with a suspected familial predisposition. TERT promoter mutations are the most common somatic hotspot human cancers. However, only two families germline have been identified to date. We present detailed histological, clinical, and molecular pathologic analyses affected details newly individuals one these previously reported families. (NM_198253.3) Chr.5:1,295,161T>C (c.-57 T>C) variants were detected all melanoma-affected (n = 18) non-diseased...
Melanocytic neoplasms have been genetically characterized in detail during the last decade. Recurrent CTNNB1 exon 3 mutations recognized distinct group of melanocytic tumors showing deep penetrating nevus-like morphology. In addition, they identified 1-2% advanced melanoma. Performing a detailed genetic analysis difficult-to-classify nevi and melanomas with mutations, we found that benign (nevi) show characteristic morphological, epigenetic traits, which distinguish them from other Malignant...