A5049412203- Advanced biosensing and bioanalysis techniques
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Electrospun Nanofibers in Biomedical Applications
- Antibiotic Resistance in Bacteria
- Antimicrobial agents and applications
- Polymer Surface Interaction Studies
- Pluripotent Stem Cells Research
- Molecular Sensors and Ion Detection
- Corneal surgery and disorders
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Luminescence and Fluorescent Materials
- Pharmacological Effects and Toxicity Studies
- Hemoglobinopathies and Related Disorders
- Conducting polymers and applications
- Neuroscience and Neural Engineering
- 3D Printing in Biomedical Research
- Iron Metabolism and Disorders
- Advanced Sensor and Energy Harvesting Materials
- Ocular Surface and Contact Lens
- Antimicrobial Resistance in Staphylococcus
- Electrochemical sensors and biosensors
- Bacteriophages and microbial interactions
- Nanocomposite Films for Food Packaging
Southeast University
2021-2024
First Hospital of China Medical University
2023
University of Georgia
2017-2022
Shanghai East Hospital
2022
Kyoto University
2019-2020
Peking University First Hospital
2015-2019
Peking University
2015-2019
Chinese Academy of Sciences
2012-2015
Technical Institute of Physics and Chemistry
2015
University of Chinese Academy of Sciences
2015
To determine the efficacy and safety of intense pulsed light (IPL) applied directly on eyelids meibomian gland expression (MGX) in treating dysfunction (MGD).IPL application periocular skin effectively improves secretion tear film break-up time (TBUT) patients with MGD/dry eye.This prospective, randomized, double-masked, controlled study involved 44 patients. One eye was randomly selected for IPL treatment; other served as a control. Study eyes received three treatments at 4-week intervals;...
Abstract Intrinsically stretchable electronics have gained extensive interest recently, due to their promising application in wearable electronics, bio‐integrated and healthcare devices. All of the components such need be mechanically robust accommodate complex movements. The design fabrication intrinsically electronic materials represent a critical challenge this emerging field. In review, we focus on latest studies covering strategies for achieving materials, recent progresses key...
To evaluate the long-term effects of intense pulsed light (IPL) combined with meibomian gland expression (MGX) in treatment dysfunction (MGD).Although IPL has been proven to be effective MGD, any report regarding its efficacy is unavailable by now.The randomly selected study eye received a series three treatments that were applied directly on eyelids an interval 4 weeks (treatment energy, 14-16 J/cm2). The control sham (0 MGX was performed both eyes. Meibomian yielding secretion score...
An organic semiconductor with high carrier mobility and efficient light absorption over a wide spectral range is of the most important yet challenging material for constructing broadband responsive photodetector. However, development such semiconductors, especially air-stable n-type small molecule still at an early stage. Here we report fabrication high-performance semiconducting crystalline nanosheets field-effect transistors, phototransistors, response broad spectrum. The assembled into...
A micelle-based and mitochondria-targeting FRET probe was fabricated to ratiometrically detect intracellular mitochondrial H<sub>2</sub>O<sub>2</sub>.
Abstract Surface‐enhanced Raman scattering (SERS) is widely used in all kinds of detection due to its ultrahigh sensitivity and selectivity. Micromotors, when as SERS sensors, or the so‐called “hotspots on fly”, can combine both controlled mobility sensing capacity, are ideal for versatile situ detection. In this work, mobile sensors successfully fabricated by growing gold nanospikes onto magnetic microsphere surfaces. These micromotors act normal characterized trace thiram, a highly toxic...
Abstract Directed differentiation methods allow acquisition of high-purity cardiomyocytes differentiated from human induced pluripotent stem cells (hiPSCs); however, their immaturity characteristic limits application for drug screening and regenerative therapy. The rapid electrical pacing has been used efficiently promoting the maturation cardiomyocytes, here we describe a simple device in modified culture plate on which hiPSC-derived can form three-dimensional self-organized tissue rings...
Survival and infection of pathogenic bacteria, such as Staphylococcus aureus (S. aureus), pose a serious threat to human health. Efficient methods for recognizing quantifying low levels bacteria are imperiously needed. Herein, we introduce metal-organic framework (MOF)-based fluorescence resonance energy transfer (FRET) nanoprobe ratiometric detection S. aureus. The utilizes blue-emitting 7-hydroxycoumarin-4-acetic acid (HCAA) encapsulated inside zirconium (Zr)-based MOFs the donor...
Chronic blood transfusions are used to alleviate anemic symptoms in thalassemia and sickle cell anemia patients but can eventually result iron overload (IO) subsequently lead severe oxidative stress cells tissues. Deferoxamine (DFO) is clinically approved treat transfusional IO, the use of chelator hindered by nonspecific toxicity poor pharmacokinetic (PK) properties humans, resulting need administer drug via long-term infusion regimens that often patient compliance. Herein, a nanochelator...
Multifunctional self‐assembled micelles composed of Pluronics F127 polymer chains are developed and investigated for chelation selective detection iron(III) in vitro iron‐overloaded cells. Tetraphenylethene (TPE) is encapsulated into the micelle core iron chelate drug deferoxamine (DFO) conjugated to generate a fluorescence quenching system termed DFO‐TFM short, where T stands TPE, F F127, M micelle. The key successful formation this due near‐ideal overlap between absorption spectrum...
The formation of biofilms by a microcolony bacteria is significant burden on the healthcare industry due to difficulty eradicating it. In this study, pH-responsive vesicles capable releasing apramycin (APR), model aminoglycoside antibiotic, in response low pH typical establishedPseudomonas aeruginosa resulted improved eradication existing comparison free drug. amphiphilic polymeric vesicle (PV) comprised block polymer poly (ethylene glycol)-block-poly 2-(dimethylamino) ethyl methacrylate...
Nesting success and chick survival of a migratory population Houbara Bustard Chlamydotis [undulata] macqueenii were studied during three consecutive years (1998–2000) in the Xinjiang province north‐west China. A total 45 nests was monitored 85 broods comprising 227 chicks captured, which 82 radio‐tracked. Start laying varied between 6 17 April but mode fell consistently 26 30 April. Mean clutch size 4.0 (sd = 0.8) (range 2–6) for early clutches 3.3 1.1) late 2–5). The average nesting 0.588...
Bioorthogonal labelling was applied to design “turn-on” fluorescent probes for sensitive and selective detection of histone acetyltransferase enzymatic activity in a simple mix-and-read manner.
Iron plays a critical role in bacterial infections and is especially for supporting biofilm formation. Until recently, Fe(III) was assumed to be the most relevant form of iron chelate therapeutic antimicrobial strategies due its natural abundance under normal oxygen physiologic conditions. Recent clinical data obtained from cystic fibrosis (CF) patients found that there actually quite an Fe(II) present sputum exists significant relationship between concentration severity disease. A...
Bacteria can evade the immune system once they are engulfed by phagocytic host cells.
The facile and scalable manufacturing of rubbery stretchable conductors is realized based on 3D printed silver nanowires their applications are demonstrated by constructing wearable photodetectors transistors.
The outer membrane of<italic>Pseudomonas aeruginosa</italic>functions primarily as a permeability barrier and imparts broad spectrum of intrinsic antibiotic resistance.
Bacteria are now becoming more resistant to most conventional antibiotics. Approaches for the treatment of multidrug-resistant bacterial infections urgently required.
Pseudomonas aeruginosa exhibits a broad spectrum of intrinsic antibiotic resistance because the limited permeability its outer membrane. Given this situation, molecules that could make Gram-negative bacteria more permeable and susceptible to large-scaffold Gram-positive antibiotics may be advantageous. Herein, we evaluate antimicrobial activity series targeted poly(ethylene glycol)-desferrioxamine/gallium (PEG-DG) conjugates can improve sensitivity P. glycopeptide vancomycin (VAN). We...