A5067376331- Cleft Lip and Palate Research
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Craniofacial Disorders and Treatments
- dental development and anomalies
- Congenital Ear and Nasal Anomalies
- Cancer-related molecular mechanisms research
- Invertebrate Immune Response Mechanisms
- RNA Interference and Gene Delivery
- Aquatic life and conservation
- Genetic Mapping and Diversity in Plants and Animals
- Tracheal and airway disorders
- Animal Nutrition and Physiology
- Skin and Cellular Biology Research
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Bacteriophages and microbial interactions
- Aldose Reductase and Taurine
- Wound Healing and Treatments
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Reproductive biology and impacts on aquatic species
- Congenital Anomalies and Fetal Surgery
- Retinoids in leukemia and cellular processes
- Wnt/β-catenin signaling in development and cancer
Sichuan University
2018-2023
State Key Laboratory of Oral Diseases
2018-2023
Guangdong Ocean University
2018-2023
Key Laboratory of Guangdong Province
2021-2023
Sun Yat-sen University
2017-2023
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2019-2023
Xiamen University
2022
Stomatology Hospital
2020-2021
Qingdao Center of Resource Chemistry and New Materials
2020
Qingdao Municipal Hospital
2019
Nonsyndromic orofacial cleft (NSOFC) is a severe birth defect that occurs early in embryonic development and includes the subtypes palate only (CPO), lip (CLO) with (CLP). Given lack of specific genetic factor analysis for CPO CLO, present study aimed to dissect landscape factors underlying pathogenesis these two using 6,986 cases 10,165 controls. By combining genome-wide association (GWAS) as well functional gene network ontology pathway analysis, we identified 18 genes/loci surpassed...
A 56-day feeding trial was conducted to study the effects of cottonseed protein concentrate (CPC) as fishmeal (FM) replacement on growth, digestive proteinase, intestinal morphology and microflora in pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatu). FM 0% (FM), 12.00% (R12), 24.00% (R24), 36.00% (R36), 48.00% (R48) 60.00% (R60) replaced with CPC, prepare six diets feed groupers. Weight gain (WG) specific growth rate (SGR) were highest R24 group, lowest coefficient...
Summary A genome‐wide association study ( GWAS ) was conducted on 15 milk production traits in Chinese Holstein. The experimental population consisted of 445 cattle, each genotyped by the GGP (GeneSeek genomic profiling)‐Bovine LD V3 SNP chip, which had 26 151 public s its manifest file. After data cleaning, 20 326 were retained for . phenotypes estimated breeding values traits, provided a dairy herd improvement program center that been collected once month 3 years. Two statistical models,...
Abstract p53 is a transcription factor with capability of regulating diverse NF-κB dependent biological progresses such as inflammation and host defense, but the actual mechanism remains unrevealed. Herein, we firstly identified two novel alternatively spliced isoforms from Litopenaeus vannamei (LvΔNp53 full-length p53, LvFLp53). We then established that exerted opposite effects on induced antimicrobial peptides (AMPs) white spot syndrome virus (WSSV) immediate-early (IE) genes expression,...
GWAS has been proven to be a powerful tool for detecting genetic variants associated with economically important traits such as production,1, 2 body conformation3, 4 and reproduction traits,5 diseases.6 The objective of this study was identify SNPs significant association effects on conformation in Chinese Holstein through the approach. experimental population consisted 445 cows, parity no. 2, raised at four farms Shandong province China. Hair follicle samples were collected individually...
An 8-week trial was performed to evaluate tributyrin effects on growth, disease resistance, lipid metabolizing, distal intestinal inflammation-, tight junctions- and apoptosis-related gene expressions caused by high-level cottonseed protein concentrate (CPC) substitution of fishmeal. Fish were fed one fishmeal (50% fishmeal) six CPC diets (27.5% 25.2% CPC). Seven isonitrogenous (48.0%) isolipidic (9.0%) formulated contain 0.0 (FM), (S00), 0.2 (S02), 0.4 (S04), 0.8 (S08), 1.6 (S16) 3.2 (S32)...
Simple sequence repeats (SSRs) of short nucleotide motifs occur very frequently in the 5' untranslated coding region (5'-UTR) genes and have been implicated regulation gene expression. In this study, we identified an SSR with a variable number CT 5'-UTR Litopenaeus vannamei IRF (LvIRF) that has shown to mediate antiviral responses by inducing expression Vago, functional homolog mammalian IFN. We then explored effects varying (CT)n on LvIRF using both dual-luciferase reporter assays Western...
Non-syndromic cleft lip with or without palate is one of the most common birth malformations. TP63 and GREM1 were recently reported to be associated NSCL/P. However, there few studies focused on their associations in non-syndromic only (NSCLO).Initial screening replication large cohorts used locate susceptible SNPs GREM1. Firstly, variations screened among 192 NSCLO cases by Sanger sequencing. Then, we selected five initial phase replicated 1,006 1,823 normal controls.Initial chi-square test...
This study conducted an 8-week feeding trial to evaluate the effects of taurine supplementation in a high-carbohydrate diet on growth performance, plasma biochemical indexes and glucose metabolism hybrid grouper (♀ Epinephelus fuscoguttatus × ♂ E. lanceolatus). Six iso-nitrogenous (45.94 %) iso-lipidic (8.71 diets were formulated containing 20 % carbohydrates (positive control group, PC) 30 (negative NC), supplemented with 0.4 (T1), 0.8 (T2), 1.2 (T3) 1.6 (T4) basis PC diet. Five hundred...
Background Burn patients are prone to infection as well immunosuppression, which is a significant cause of death. Currently, there lack prognostic biomarkers for immunosuppression in burn patients. This study was conducted identify immune-related genes that prognosis post-burn and potential targets immunotherapy. Methods We downloaded the gene expression profiles clinical data 213 79 healthy samples from Gene Expression Omnibus (GEO) database. Immune infiltration analysis used proportion...
We investigated the effects of low and high doses β-conglycinin ameliorative sodium butyrate (based on high-dose β-conglycinin) growth performance, serum immunity, distal intestinal histopathology, gene, protein expression related to health in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂). The results revealed that instantaneous rate (IGR) significantly increased, decreased, increased low-dose (bL), high-level (bH) plus (bH-NaB), respectively. feed coefficient ratio (FCR)...
The polymorphism of the simple sequence repeat (SSR) in 5' untranslated coding region (5'-UTR) antiviral gene IRF (LvIRF) has been shown to be implicated resistance viral pathogens shrimp Litopenaeus vannamei (L. vannamei). In this study, we explored potential (CT)n-SSR marker disease breeding and hereditary property traits offspring. From 2018 2021, eight populations were generated through crossbreeding by selecting individuals according microsatellite genotyping. Our results demonstrated...
A recent study reported that zinc finger protein (ZNF)281 is a tumor-suppressive long non-coding (lnc)RNA in glioma. The present investigated the role of ZNF281 non-small cell lung cancer (NSCLC). expression paired and non-cancerous tissues from patients with NSCLCs was analyzed by RNA extraction reverse transcription-quantitative-PCR. 5-year follow up on performed to analyze prognostic value for NSCLC. Cell transfections or phosphatase tensin homolog (PTEN) vector microRNA (miR)-221 mimic...
The single-nucleotide polymorphism (SNP) rs2235371 ( IRF6 V274I) is associated with nonsyndromic cleft lip or without palate (NSCL/P) in Han Chinese and other populations but appears to be a functional effect. To find the common etiologic variant variants within haplotype tagged by rs2235371, we carried out targeted sequencing of an interval containing 159 NSCL/P. This study revealed that SNP rs12403599, promoter, all phenotypes NSCL/P, especially (NSCLO) subphenotype it, microform (MCL)....
Oligosaccharides have recently received much attention from researchers owing to their multiple biological activities. This study was conducted investigate the effects of a diet with reduced fish meal and chitosan oligosaccharide (COS) supplementation on hybrid grouper ( Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂). Seven isonitrogenous isolipidic types were formulated feed groupers for 56 days. To prepare feed, reference (FM group) containing 55% used. Concentrated cottonseed protein...
The supplementation of gossypol in excess is noted to cause detrimental effects such as the reduction antioxidant enzymes and disruption lipid metabolism animals. Studies regarding different levels are very rare; thus, this study was conducted evaluate low high dietary with 0.13 % sodium butyrate (NaB) under conditions on growth performance intestinal health hybrid grouper ( Epinephelus fuscoguttatus ♀× lanceolatus ♂). Four treatments were used: Feed containing 40% fish meal used control...
We aimed to study the association between rs7525173, rs2236518, rs2493264 single nucleotide polymorphism (SNP) in PRDM16 gene, smoking, alcohol exposures, and nonsyndromic cleft lip with or without palate (NSCL/P).
Different doses of β-conglycinin produce different regulations on the intestinal health aquatic animals, affecting absorption nutrients, indirectly changing water quality. Sodium butyrate (NaB) can effectively alleviate negative effects caused by high-dose β-conglycinin. We investigated positive response to low-dose (1.5%, bL) and (6.0%, bH) supplementation with NaB (6.0% + 0.13% NaB, bHNaB) in terms pollutants, microbiota, transcriptome, metabolome hybrid grouper ( Epinephelus fuscoguttatus...
The purpose of this study is to analyze the clinical characteristics patients with Van der Woude syndrome (VWS) and detect variations in each patient. Finally, combination genotype phenotype can make a clear diagnosis VWS different penetrance. Five Chinese pedigree were enrolled. Whole exome sequencing proband was performed, potential pathogenic variation further verified by Sanger patient their parents. human mutant IRF6 coding sequence generated from full-length plasmid site-directed...