A5012971197- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Synthesis and Reactivity of Heterocycles
- Cyclopropane Reaction Mechanisms
- Supramolecular Self-Assembly in Materials
- Supramolecular Chemistry and Complexes
- Molecular Sensors and Ion Detection
- Medical and Biological Sciences
- Dental Education, Practice, Research
- X-ray Diffraction in Crystallography
- Nanopore and Nanochannel Transport Studies
- Luminescence and Fluorescent Materials
- Crystallization and Solubility Studies
- Photochromic and Fluorescence Chemistry
- Cancer therapeutics and mechanisms
- Fluorine in Organic Chemistry
- Chemical Synthesis and Analysis
- Craniofacial Disorders and Treatments
- Synthesis and Reactions of Organic Compounds
- Plasmonic and Surface Plasmon Research
- Metal-Organic Frameworks: Synthesis and Applications
- Molecular Junctions and Nanostructures
- Carbon Nanotubes in Composites
- Graphene and Nanomaterials Applications
Romanian Academy
2015-2025
Clinical Emergency Hospital Bucharest
2025
Spitalul Clinic C.F. Iasi
2024
Czech Academy of Sciences, Institute of Macromolecular Chemistry
2014-2024
Iuliu Hațieganu University of Medicine and Pharmacy
2015-2020
Institute of Macromolecular Chemistry
2015-2020
Institutul de Chimie Macromoleculară Petru Poni
2012-2016
Aarhus University
2010-2013
Danish National Research Foundation
2012-2013
Institut Pprime
2013
A helping strand: method to selectively form copper nanoparticles in solution using double-stranded DNA has been developed. The size of the is controlled by length dsDNA template, and single-stranded did not act as a template (see scheme). Single-stranded overhangs were used prepare nanostructure which two metallized segments linked together nonmetallized rigid linker. Detailed facts importance specialist readers are published "Supporting Information". Such documents peer-reviewed, but...
Abstract The bacterial KcsA channel conducts K + cations at high rates while excluding Na cations. Herein, we report an artificial ion‐channel formed by H‐bonded stacks of crown‐ethers, where cation conduction is highly preferred to macrocycles aligned along the central pore surround in a similar manner water around hydrated cation, compensating for energetic cost their dehydration. In contrast, does not fit macrocyclic binding sites, so its dehydration completely compensated. present...
Abstract Indolizines 4 and biindolizines 6 can be synthesized in moderate yields a consecutive one‐pot three‐component process by coupling/1,3‐dipolar cycloaddition sequence of (hetero)arenecarbonyl chloride 1 , terminal alkyne 2 suitable 1‐(2‐oxoethyl) pyridinium bromide 3 or 5 respectively ( Schemes ). After the Sonogashira coupling, [2+3] situ formed ylide, an allyl‐type 1,3‐dipole, furnishes cycloadduct that is instantaneously oxidatively aromatized to give highly fluorescent indolizine...
Low-energy electrons (LEEs) play an important role in nanolithography, atmospheric chemistry, and DNA radiation damage. Previously, the cleavage of specific chemical bonds triggered by LEEs has been demonstrated a variety small organic molecules such as halogenated benzenes nucleobases. Here we present strategy that allows for first time to visualize electron-induced dissociation single within complex, but well-defined self-assembled nanostructures. We employ atomic force microscopy image...
The electronic structure of DNA is determined by its nucleotide sequence, which for instance exploited in molecular electronics. Here we demonstrate that also the strand breakage induced low-energy electrons (18 eV) depends on sequence. To determine absolute cross sections electron single breaks specific 13 mer oligonucleotides used atomic force microscopy analysis origami based nanoarrays. We investigated sequences 5′-TT(XYX)3TT with X = A, G, C and Y T, BrU 5-bromouracil found break...
Functional G-quartet hydrogels formed from natural guanosine cross linked with benzene-1,4-diboronic acid and Mg<sup>2+</sup> support cell growth no visible signs of gel degradation.
In this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating β-cyclodextrin (β-CD) boronic acid linkers into matrix to enhance antibacterial activity against Staphylococcus aureus (S. aureus). We systematically investigated how varying the number free moieties (ranging from two six), along with guanosine β-CD content, influences both structural integrity antimicrobial efficacy these materials. Comprehensive characterization using FTIR, circular...
DNA origami, the folding of a long single-stranded sequence (scaffold strand) by hundreds short synthetic oligonucleotides (staple strands) into parallel aligned helices, is highly efficient method to form advanced self-assembled DNA-architectures. Since molecules and various materials can be conjugated each staple strands, origami offers unique possibility arranging in well-defined positions on structured surface. Here we combine action light with AFM nanostructures study production singlet...
Linear and cross-linked dynamic constitutional frameworks generated from reversibly interacting linear PEG/core constituents cationic sites shed light on the dominant coiling versus DNA binding behaviours, closer to histone wrapping mechanism.
Abstract The bacterial KcsA channel conducts K + cations at high rates while excluding Na cations. Herein, we report an artificial ion‐channel formed by H‐bonded stacks of crown‐ethers, where cation conduction is highly preferred to macrocycles aligned along the central pore surround in a similar manner water around hydrated cation, compensating for energetic cost their dehydration. In contrast, does not fit macrocyclic binding sites, so its dehydration completely compensated. present...
Let loose in the red-light district: “Caged” DNAs are described that can be activated by light of selectable wavelength. This is possible with, for example, red light, which significantly less damaging than UV and permeate deeply into tissues (see scheme). Supporting information this article available on WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700641_s.pdf or from author. Please note: The publisher not responsible content functionality any supporting supplied authors. Any...
The biologically and clinically important nuclear enzyme human topoisomerase I relaxes both positively negatively supercoiled DNA binds consequently with supercoils of positive or negative sign a strong preference over relaxed DNA. One scheme to explain this relies on the existence secondary binding site in facilitating nodes characteristic for plectonemic Here we demonstrate ability induce formation synapses at protein containing filaments using atomic force microscopy imaging. By means...
Abstract We have studied spectral-luminescent properties of the monomethine cyanine dyes both in their free states and presence either double-stranded deoxyribonucleic acids (dsDNAs) or single-stranded ribonucleic (RNAs). The possess low fluorescence intensity an unbound state, which is increased up to 479 times nucleic acids. In RNAs, increase was stronger than that observed dsDNA. Next, we performed staining live fixed cells by all prepared dyes. proved be cell nuclear membrane permeant....
The amount of unfolded proteins is increased in cancer cells, leading to endoplasmic reticulum (ER) stress. Therefore, cells are sensitive drugs capable further enhancing ER Examples such include the clinically approved proteosome inhibitors bortezomib and carfilzomib. Unfortunately, known stress inducers exhibit dose-limiting side effects that justify search for better, more cancer-specific this type. Herein, we report on FeC 2, which binds prevents their processing, thereby ROS increase...
The polyplexes formed by nucleic acids and polycations have received a great attention owing to their potential application in gene therapy. In our study, we report experimental results modeling outcomes regarding the optimization of polyplex formation between double-stranded DNA (dsDNA) poly(ʟ-Lysine) (PLL). quantification binding efficiency during was performed processing images captured from gel electrophoresis assays. design experiments (DoE) response surface methodology (RSM) were...
Patterns of the protein streptavidin on DNA origami are printed onto a functionalized surface. The streptavidins linked to via disulfide spacer and these conjugates self-organise into predetermined pattern origami. structure immobilises biotin-SAM-functionalized Au By cleavage is separated from streptavidins, leaving at
A novel supramolecular approach for the preparation of new non-toxic systems staining cellular organelles is described.
Microbial infections represent a significant health risk, often leading to severe complications and, in some cases, even fatalities. As result, there is an urgent need explore innovative drug delivery systems and alternative therapeutic techniques. The photothermal therapy has emerged as promising antibacterial approach the focus of this study. Herein, we report successful synthesis two distinct supramolecular composite hydrogels by incorporating graphene oxide (GO) single-walled carbon...
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