A5052096613- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Vascular anomalies and interventions
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Cardiac electrophysiology and arrhythmias
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Sports injuries and prevention
- Medical Imaging and Pathology Studies
- Cardiac Arrest and Resuscitation
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Cardiac Imaging and Diagnostics
- Pericarditis and Cardiac Tamponade
- Mechanical Circulatory Support Devices
- Systemic Sclerosis and Related Diseases
- Infective Endocarditis Diagnosis and Management
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
Leiden University Medical Center
2013-2025
Leiden University
2006-2022
University Medical Center Utrecht
2021
Institute of Cardiology
2009
Tel Aviv University
2005
Sheba Medical Center
2005
Texas A&M University
1993
Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate feasibility and effects sacubitril/valsartan treatment single-centre cohort patients.Data on all consecutive adult (n=20, mean age 46 years, 50% women) RV biventricular circulation treated our centre reported. Patients ejection fraction ≤35% who were...
Patients with a systemic right ventricle (sRV) in the context of transposition great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are prone to sRV dysfunction. Pharmacological options for failure remain poorly defined. This study aims investigate tolerability and effects sacubitril/valsartan on adult patients sRV.In this two-centre, prospective cohort study, all consecutive symptomatic heart at least moderately reduced systolic function were initiated underwent...
Objective To determine factors associated with coronary artery disease (CAD) and ischaemic stroke in ageing adult congenital heart (ACHD) patients. Methods We performed a multicentre case–control study, using data from the national CONgenital CORvitia (CONCOR) registry to identify ACHD patients within five participating centres. Patients CAD were matched (1:2 ratio) without on age, CHD defect group gender. (or transient attack) similarly. Medical charts reviewed standardised questionnaire...
In congenitally corrected transposition of the great arteries, morphological right ventricle supports systemic circulation. This chronic exposure to pressure overload ultimately leads ventricular (sRV) dysfunction and heart failure. Pharmacological options for treatment sRV failure are poorly defined no solid recommendations made in most recent guidelines. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors a new class antihyperglycaemic drugs that have been demonstrated significantly reduce...
Background Short-term improvements in quality of life (QOL) have been reported adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes sRV treated Methods In this single-centre, prospective cohort study, symptomatic completed Netherlands Organisation for Applied Scientific Research/Academic Hospital Leiden Questionnaire Adult’s Health-Related Quality Life (TAAQOL) at...
To evaluate the impact of long term cardiac resynchronisation therapy (CRT) on left atrial and ventricular (LV) reverse remodelling reversal to sinus rhythm (SR) in patients with heart failure fibrillation (AF).74 consecutive (age 68 (8) years; 67 men) advanced AF (20 persistent 54 permanent) were implanted a CRT device.Patients evaluated clinically (New York Heart Association (NYHA) class, quality life, six minute walk test) echocardiographically (LV ejection fraction, LV diameters,...
Given the compelling evidence on effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in conventional heart failure population, SGLT2i deserve exploration systemic right ventricular (sRV) failure. The initial experience with dapagliflozin sRV patients is described, a focus tolerability and short-term effects clinical outcomes.Ten (70% female, median age 50 years [46.5-52]) symptomatic who received 10 mg per day top optimal medical therapy between 04-2021 01-2023 were included....
This study assessed adult survival and morbidity patterns in patients who underwent atrial correction according to Mustard or Senning for transposition of the great arteries (TGA).In 76 with TGA (59% male) after correction, long-term were investigated three periods: early (<15 years postoperatively), midterm (15-30 postoperatively) late (>30 postoperatively).The technique was performed 41 (54%) patients, 35 (46%) aged 3.1 (IQR: 2.1-3.8) 1.0 0.6-3.1; p<0.01) years, respectively. Adult 82% at...
Background Patients with transposition of the great arteries corrected by an atrial switch operation experience major clinical events during adulthood, mainly heart failure (HF) and arrhythmias, but data on emerging risks remain scarce. We assessed risk for course in provided a novel score event-free survival. Methods Results This multicenter study observed 167 patients (61% Mustard procedure; age, 28 [interquartile range, 24-36] years) 13 (interquartile 9-16) years, which 16 (10%) died, 33...
Background: Kommerell’s diverticulum is a rare vascular anomaly characterized as an outpouch at the onset of aberrant subclavian artery. In variant right-sided aortic arch, trachea and esophagus are enclosed dorsally by arch. configuration left artery, persisting ductus arteriosus or ductal ligament enclose lateral side, forming ring which may result in (symptomatic) esophageal tracheal compression. Spontaneous rupture aneurysmatic has also been reported. Due to rarity this condition...
The Leiden Convention coronary coding system structures the large variety of anatomical patterns; isolated and in congenital heart disease. It is widely used by surgeons but not cardiologists as uses a surgeons' cranial view. Since thoracic work closely together, practical for both disciplines mandatory. To this purpose, 'surgical' was adapted to an 'imaging' system, extending its applicability different cardiac imaging techniques.
In the transposition of great arteries (TGA), alterations in hemodynamics and oxygen saturation could result fibrotic remodeling, but histological studies are scarce. We aimed to investigate fibrosis innervation state full spectrum TGA correlate findings clinical literature. Twenty-two human postmortem hearts, including without surgical correction (n = 8), after Mustard/Senning 6), arterial switch operation (ASO, n were studied. newborn uncorrected specimens (1 day-1.5 months), significantly...
Introduction: Patients with established arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) based on task force (TF) criteria and tachycardia (VT) are at risk of VT recurrence sudden death. Data patients due to (RV) scar not fulfilling TF lacking. The purpose this study was assess the long‐term arrhythmia rate outcome in scar‐related without a diagnosis ARVC/D. Methods: Sixty‐four (age 43.5 ± 15 years, 49 males) presenting nonischemic RV origin were studied. Scar identified by...
Objective: Evaluation of the relation between clinical characteristics and incidence recurrent ventricular arrhythmias (VAs) or death during long‐term follow‐up in a cohort 300 consecutive ischemic heart disease (IHD) patients who had survived an episode sudden cardiac arrest (SCA). Background: Survivors life‐threatening VA are at high risk for events. Methods: A total survivors SCA with IHD were included standardized screening evaluation protocol. Multivariable Cox regression analysis was...
Introduction: Diagnosis of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is based on a set criteria proposed by the International Task Force (TF) for Cardiomyopathies in 1994. To fulfill these criteria, presence both electrocardiographic and anatomical abnormalities must be assessed with ECG imaging techniques, respectively. This may difficult patients early/mild forms disease as detectable structural still absent. We evaluated which presenting tachycardia (VT) serial...