A5081034537- Congenital Heart Disease Studies
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Coronary Artery Anomalies
- Cardiac Arrhythmias and Treatments
- Vascular anomalies and interventions
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Genetic and Kidney Cyst Diseases
- Cardiac Valve Diseases and Treatments
- Mechanical Circulatory Support Devices
- Pericarditis and Cardiac Tamponade
- Congenital heart defects research
- Heart Rate Variability and Autonomic Control
- Renal and related cancers
- ECG Monitoring and Analysis
- Microtubule and mitosis dynamics
- Kruppel-like factors research
- Diabetes Treatment and Management
- Infective Endocarditis Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
Leiden University Medical Center
2009-2025
Leiden University
2021-2024
Golden Jubilee National Hospital
2024
University Medical Center Utrecht
2021
Deutsches Herzzentrum München
2020
Institute of Cytology and Genetics
2018
Siberian Branch of the Russian Academy of Sciences
2018
University of Toledo
2011
University of Alabama at Birmingham
2011
Primary cilia are cellular protrusions that serve as mechanosensors for fluid flow. In endothelial cells (ECs), they function by transducing local blood flow information into functional responses, such nitric oxide production and initiation of gene expression. Cilia present on ECs in areas low or disturbed absent high the embryonic heart, high-flow regime applies to endocardial cushion area, absence here coincides with process endothelial-to-mesenchymal transition (EndoMT).In this study, we...
Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate feasibility and effects sacubitril/valsartan treatment single-centre cohort patients.Data on all consecutive adult (n=20, mean age 46 years, 50% women) RV biventricular circulation treated our centre reported. Patients ejection fraction ≤35% who were...
Heart failure (HF) is the principal cause of morbidity and mortality in adults with congenital heart disease (ACHD). Robust evidence-based treatment options are lacking.
Patients with a systemic right ventricle (sRV) in the context of transposition great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are prone to sRV dysfunction. Pharmacological options for failure remain poorly defined. This study aims investigate tolerability and effects sacubitril/valsartan on adult patients sRV.In this two-centre, prospective cohort study, all consecutive symptomatic heart at least moderately reduced systolic function were initiated underwent...
The loss of primary cilia is a prerequisite for flow-induced endothelial-to-mesenchymal transition in heart development.
Abstract Endothelial cells (EC) translate biomechanical forces into functional and phenotypic responses that play important roles in cardiac development. Specifically, EC areas of high shear stress, i.e., the outflow tract atrioventricular canal, are characterized by expression Krüppel‐like factor 2 ( Klf2 ) transforming growth factor‐beta (Tgfβ)‐driven endothelial‐to‐mesenchymal transition. Extraembryonic venous obstruction (venous clip model) results congenital heart malformations,...
The implantable cardiac defibrillator/cardiac resynchronization therapy with defibrillator-based HeartLogic™ algorithm has recently been developed for early detection of impending decompensation in heart failure (HF) patients; but whether this novel can reduce HF hospitalizations not evaluated. We investigated if activation the HeartLogic reduces number hospital admissions decompensated a 1 year post-activation period as compared pre-activation period.Heart patients an defibrillator ability...
In congenitally corrected transposition of the great arteries, morphological right ventricle supports systemic circulation. This chronic exposure to pressure overload ultimately leads ventricular (sRV) dysfunction and heart failure. Pharmacological options for treatment sRV failure are poorly defined no solid recommendations made in most recent guidelines. Sodium-glucose cotransporter 2 (SGLT-2) inhibitors a new class antihyperglycaemic drugs that have been demonstrated significantly reduce...
Background Short-term improvements in quality of life (QOL) have been reported adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes sRV treated Methods In this single-centre, prospective cohort study, symptomatic completed Netherlands Organisation for Applied Scientific Research/Academic Hospital Leiden Questionnaire Adult’s Health-Related Quality Life (TAAQOL) at...
Extended reality (XR) modalities in health care are quickly evolving. There is a lack of systematically described developmental process and the "how to" execute business-case guidance. This article formulates systematic approach on technical steps generation to guide iterative development an XR tool. An international expert group was established several available frameworks related entrepreneurship were used generate recommendations. Our ongoing experience with life cycle tool for...
Given the compelling evidence on effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in conventional heart failure population, SGLT2i deserve exploration systemic right ventricular (sRV) failure. The initial experience with dapagliflozin sRV patients is described, a focus tolerability and short-term effects clinical outcomes.Ten (70% female, median age 50 years [46.5-52]) symptomatic who received 10 mg per day top optimal medical therapy between 04-2021 01-2023 were included....
Background Patients with transposition of the great arteries corrected by an atrial switch operation experience major clinical events during adulthood, mainly heart failure (HF) and arrhythmias, but data on emerging risks remain scarce. We assessed risk for course in provided a novel score event-free survival. Methods Results This multicenter study observed 167 patients (61% Mustard procedure; age, 28 [interquartile range, 24-36] years) 13 (interquartile 9-16) years, which 16 (10%) died, 33...
Background: Kommerell’s diverticulum is a rare vascular anomaly characterized as an outpouch at the onset of aberrant subclavian artery. In variant right-sided aortic arch, trachea and esophagus are enclosed dorsally by arch. configuration left artery, persisting ductus arteriosus or ductal ligament enclose lateral side, forming ring which may result in (symptomatic) esophageal tracheal compression. Spontaneous rupture aneurysmatic has also been reported. Due to rarity this condition...
The Leiden Convention coronary coding system structures the large variety of anatomical patterns; isolated and in congenital heart disease. It is widely used by surgeons but not cardiologists as uses a surgeons' cranial view. Since thoracic work closely together, practical for both disciplines mandatory. To this purpose, 'surgical' was adapted to an 'imaging' system, extending its applicability different cardiac imaging techniques.
Aim Early detection of impending fluid retention and timely adjustment (medical) therapy can prevent heart failure related hospitalizations. The multisensory cardiac implantable electronic device (CIED) based algorithm HeartLogic TM aims to alert in case retention. aim the current analysis is evaluate performance guided care path a real-world population investigate whether height index duration state are indicative degree Methods Consecutive adult patients with CIED an activated were...
In the transposition of great arteries (TGA), alterations in hemodynamics and oxygen saturation could result fibrotic remodeling, but histological studies are scarce. We aimed to investigate fibrosis innervation state full spectrum TGA correlate findings clinical literature. Twenty-two human postmortem hearts, including without surgical correction (n = 8), after Mustard/Senning 6), arterial switch operation (ASO, n were studied. newborn uncorrected specimens (1 day-1.5 months), significantly...
The implantable cardiac defibrillator-based HeartLogic algorithm aims to detect impending fluid retention in patients with heart failure (HF). Studies show that is safe integrate into clinical practice. current study investigates whether provides benefit on top of standard care and device telemonitoring HF.A multicenter, retrospective, propensity-matched cohort analysis was performed HF defibrillators, it compared conventional telemonitoring. primary endpoint the number worsening events....
We present the case of a 52-year-old woman with cardiogenic shock and refractory right ventricular failure due to spontaneous dissection coronary artery. She remained dependent on mechanical support for several weeks. Both assist device implant bidirectional cavopulmonary anastomosis were explored as long-term options. A history malignancy possible functional recovery resulted in decision favour concomitant tricuspid valve annuloplasty. Postoperatively her clinical condition improved...