A5102011232- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- HIV/AIDS Research and Interventions
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Breastfeeding Practices and Influences
- Pelvic floor disorders treatments
- Cerebral Palsy and Movement Disorders
- Hemodynamic Monitoring and Therapy
- Hernia repair and management
- Urologic and reproductive health conditions
- Animal Diversity and Health Studies
- Anorectal Disease Treatments and Outcomes
- Radiation Dose and Imaging
- Inclusion and Disability in Education and Sport
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Esophageal and GI Pathology
- Plant Toxicity and Pharmacological Properties
- Phytochemical and Pharmacological Studies
- Pathogenesis and Treatment of Hiccups
- Gestational Diabetes Research and Management
- Trypanosoma species research and implications
- HIV-related health complications and treatments
- Bacterial Identification and Susceptibility Testing
Beijing Tongren Hospital
2023
Capital Medical University
2022-2023
Wuhan Children's Hospital
2023
Huazhong University of Science and Technology
2022-2023
Zhejiang Normal University
2022
Beijing Friendship Hospital
2022
Peking University First Hospital
2021
Peking University
2021
Zigong First People's Hospital
2020
Merck & Co., Inc., Rahway, NJ, USA (United States)
2016-2019
Doravirine is a novel, nonnucleoside reverse transcriptase inhibitor with demonstrated efficacy in treatment-naive adults HIV-1.In this open-label, active-controlled, noninferiority trial, HIV-1 virologically suppressed for ≥6 months on 2 nucleoside inhibitors plus boosted protease inhibitor, elvitegravir, or non-nucleoside were randomized (2:1) to switch once-daily, single-tablet doravirine 100 mg lamivudine 300 and tenofovir disoproxil fumarate (DOR/3TC/TDF) continue their current therapy...
A low CD4/CD8 ratio during treated HIV identifies individuals with heightened immunoactivation and excess mortality. Whether ART regimens elicit distinct recovery remains unknown. We aimed to compare the efficacy of an integrase inhibitor versus a non-nucleoside normalize ratio.We conducted post hoc analysis STARTMRK study, randomized, blinded, double-dummy Phase III trial raltegravir efavirenz, each in combination tenofovir/emtricitabine, treatment-naive HIV-infected adults. Blinding was...
Raltegravir 1200mg (2×600mg tablets) once daily (QD) demonstrated noninferior efficacy and similar safety to raltegravir 400mg twice (BID) at week 48 of the ONCEMRK trial. Here, we report 96 results from this study.ONCEMRK is a phase 3, multicenter, double-blind, noninferiority trial comparing QD with BID in treatment-naive HIV-1-infected adults. Participants were assigned (2:1) 2×600mg or BID, both emtricitabine tenofovir disoproxil fumarate (FTC/TDF) for weeks. Randomization was stratified...
Abstract Background Antiretroviral therapy in human immunodeficiency virus (HIV)-infected women and blacks merits particular scrutiny because these groups have been underrepresented clinical trials. Methods To document the effects of raltegravir across sex racial lines, we conducted a pooled subgroup analysis efficacy safety 400 mg BID plus tenofovir-emtricitabine by (women vs men) self-identified race (black non-black) using phase 3 studies treatment-naive patients. Results Study...
Abstract Background Doravirine is a novel, non-nucleoside reverse-transcriptase inhibitor (NNRTI) that has demonstrated efficacy in two Phase 3 trials treatment-naïve adults with HIV-1. Methods This open-label, active-controlled, noninferiority (NI) trial evaluated once-daily single-tablet regimen of doravirine 100 mg, lamivudine 300 and tenofovir disoproxil fumarate mg (DOR/3TC/TDF) vs. continuation current therapy HIV-1 virologically suppressed for ≥6 months on stable NRTIs plus boosted...
Abstract Background: Reflux esophagitis (RE) is a common disease which caused by the reflux of stomach and duodenal contents. As classic prescription traditional Chinese medicine, Chaihu-Shugan-San (CSS) has been used in treatment RE. However, no critically designed overview to evaluate systematic review CSS for RE carried out. The purpose this study efficacy safety Methods analysis: We will search following sources without restrictions date, language, or publication status: PubMed, Cochrane...
Subtraction coronary CT angiography (CCTA) may reduce blooming and beam-hardening artifacts. This study aimed to assess its value in improving the diagnostic accuracy of readers with different experience levels.We prospectively enrolled patients target segment who underwent CCTA invasive (ICA). Target images were independently evaluated by three groups radiologists levels using ICA as standard reference. Diagnostic was measured area under curve (AUC), ≥50% stenosis cut-off value.In total,...
It is elusive that whether Mediterranean diet helps prevent gestational diabetes. This meta-analysis aims to study the efficacy of for diabetes mellitus.We have systematically searched PubMed, EMbase, Web science, EBSCO and Cochrane library databases, included randomized controlled trials (RCTs) reported effect on diabetes.We five eligible RCTs in this meta-analysis. Compared with control intervention pregnant women, could substantially decrease incidence mellitus (OR = 0.64; 95% CI 0.51...
Objective To study the therapeutical effects of total flavonoid pteris multifida in nonbacterial prostatitis rats and possible mechanism. Methods Fifty- eight male Wistar were intraperitoneally injected with rat prostate protein purification liquid mixture immune adjuvant for preparation experimental model chronic prostatitis. The randomly divided into 6 groups(8 each group): blank group, group(high, medium, low dose groups), prostat group.The fed on relevant drugs or same volume...
Ornidazole is frequently used for the prevention and treatment of anaerobic infections after caesarean section. There still a lack data on excretion ornidazole in breast milk. Therefore, aim this study was to investigate transfer into colostrum assess risk infant exposure drug via Population pharmacokinetic analysis conducted using datasets plasma milk concentrations obtained from 77 breastfeeding women examine kinetics ornidazole. Various factors that may affect were investigated. The final...
目的 探讨个性化疼痛护理对肾结石患者疼痛的临床效果。 方法 选取80例急诊肾结石患者，采用奇偶数字法分为观察组和对照组，每组40例，对照组患者采用常规护理干预，观察组患者在对照组的基础上给予个性化疼痛护理，比较两组患者的护理满意度、护理前后的疼痛程度以及负面情绪变化。 结果 观察组满意度(97.50%)高于对照组(72.50%)(χ2＝9.804，P<0.05)。干预后观察组VAS评分为(2.55±1.01)分、SAS评分为(34.66±4.29)分、SDS评分为(35.08±4.33)分，对照组VAS评分为(4.09±1.05)分、SAS评分为(43.49±3.61)分、SDS评分为(44.21±4.05)分，观察组均优于对照组(t＝6.685、9.960、9.739，均P<0.05)。 结论 个性化疼痛护理能有效提高患者对护理工作的满意度，改善患者的疼痛程度及负面情绪。
Objective To evaluate the clinical effect of external application with vitamin B1 injection combined dexamethasone in treatment postpartum perineal swelling. Methods 92 patients who underwent vaginal delivery and had swelling department obstetrics our hospital were randomly divided into experimental group control group. The received wet dressing 50% MgSO4, while injection. Compared time pain relief, subsided time, degree before at different points after treatment, overall curative...
OBJECTIVE To investigate the factors regarding recovery of postoperative blood pressure aldosterone producing adenoma (APA) patients. METHODS Sixty-eight patients with APA were recruited and their data including retinal vessel by Doppler sonography, urinary trace albumin, pathological changes renal biopsy adrenal tissues around analyzed in order to determine correlation between these durative hypertension. RESULTS Postoperative hypertension occurred 14 cases (41.2%) increased resistance...
Objective To explore the clinical effect of transurethral resection prostate (TURP) combined with tension-free herniorrhaphy in treatment prostatic hyperplasia inguinal hernia. Methods 150 patients complicated hernia were randomly divided into group (75 cases) and staging cases). TURP hernioplasty was performed by stages, while repair at first operation. The indexes operation, hospitalization indexs, complications postoperative follow-up compared between two groups. Results The...