A5089346460- Mosquito-borne diseases and control
- Malaria Research and Control
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Bird parasitology and diseases
- Aquaculture disease management and microbiota
- Vector-borne infectious diseases
- Complement system in diseases
- Primate Behavior and Ecology
- Venomous Animal Envenomation and Studies
- Synthesis and Biological Evaluation
- Vibrio bacteria research studies
- HIV Research and Treatment
Fundação Oswaldo Cruz
2015-2025
Karolinska Institutet
2024
Faculdades Oswaldo Cruz
2024
Universidade Federal de Ouro Preto
2021
Abstract Rapid Diagnostic Tests (RDTs) have been an important diagnostic tool for detecting P. falciparum malaria in resource-limited settings. Most tests are designed to detect the Histidine-rich Protein 2 (HRP2). Parasites lacking pfhrp2 and its homologous pfhrp3 reported several regions, with prevalence reaching 100% certain areas. To better characterize isolates circulating Brazil-Venezuela-Guyana tri-border region, we performed a comprehensive analysis of 365 samples collected between...
Blood infection by the simian parasite, Plasmodium simium, was identified in captive (n = 45, 4.4%) and wild Alouatta clamitans monkeys 20, 35%) from Atlantic Forest of southern Brazil. A single malaria symptomatic monkey presented clinical haematological alterations. high frequency vivax-specific antibodies detected among these monkeys, with 87% testing positive against P. vivax antigens. These findings highlight possibility as a zoonosis remaining its impact on epidemiology disease.
Plasmodium falciparum and vivax have evolved with host switches between non-human primates (NHPs) humans. Studies on the infection dynamics of species in NHPs will improve our understanding evolution these parasites; however, such studies are hampered by difficulty handling animals field. The aim this study was to detect genomic DNA from faeces New World monkeys. Faecal samples 23 Alouatta clamitans Centre for Biological Research Indaial (Santa Catarina, Brazil) were collected. Extracted...
Plasmodium simium is a parasite from New World monkeys that most closely related to the human malaria vivax; it also naturally infects humans. The blood-stage infection of P. vivax depends on Duffy binding protein II (PvDBPII) and its cognate receptor erythrocytes, antigen for chemokines (hDARC), but there no information erythrocytic invasion pathway. genes encoding DBP (PsDBPII) simian DARC (sDARC) were sequenced Southern brown howler (Alouatta guariba clamitans) infected with because may...
Human malaria due to zoonotic transmission has been recorded in the Atlantic Forest, an extra-Amazonian area Brazil, which are a challenge for control. Naturally acquired humoral immune response against pre-erythrocytic and erythrocytic antigens of Neotropical primates (NP) was evaluated here improve knowledge about exposure those animals support identification potential reservoirs disease Forest. Blood samples 154 monkeys from three areas Forest were used identify IgG antibodies peptides...
Zoonotic transmission is a challenge for the control and elimination of malaria. It has been recorded in Atlantic Forest, outside Amazon which endemic region Brazil. However, only very few studies have assessed antibody response, especially IgM antibodies, Neotropical primates (NP). Therefore, order to contribute better understanding immune response different hosts facilitate identification potential reservoirs, this study, naturally acquired responses against Plasmodium antigens were...
<title>Abstract</title> Rapid Diagnostic Tests (RDTs) have been an important diagnostic tool for detecting <italic>P. falciparum</italic> malaria in resource-limited settings. Most tests are designed to detect the Histidine-rich Protein 2 (HRP2). Parasites lacking <italic>pfhrp2</italic> and its homologous <italic>pfhrp3</italic> reported several regions, with prevalence reaching 100% certain areas. To better characterize isolates circulating Brazil-Venezuela-Guyana tri-border region, we...
Background High-copy genomic sequences could be used as PCR targets for the detection of Plasmodium infections, providing increased sensitivity over single- or low-copy genes. Mitochondrial genomes malaria parasites are present in multiple copies a single mitochondrion, and each parasite has many mitochondria. Here, we describe development seven species-specific qPCR assays diagnosis vivax falciparum , targeting coding non-coding mitochondrial regions. Methods The optimization protocols...
Acute chagasic encephalitis is a clinically severe central nervous system (CNS) manifestation. However, the knowledge of form Chagas disease incomplete. The role muscarinic acetylcholine receptor (mAChR) on mice behavior and brain lesions induced by Trypanosoma cruzi (Colombian strain) was herein investigated in treated with mAChR agonist antagonist (carbachol atropine), respectively. Immunosuppressed or non-immunosuppressed were intracerebroventricularly (icv) intraperitoneally (ip)...