A5050229884- Autophagy in Disease and Therapy
- Poisoning and overdose treatments
- Restraint-Related Deaths
- Forensic Toxicology and Drug Analysis
- Neuroscience of respiration and sleep
- Calcium signaling and nucleotide metabolism
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Mitochondrial Function and Pathology
- Pesticide Exposure and Toxicity
- Pulmonary Hypertension Research and Treatments
- Muscle and Compartmental Disorders
- Nitric Oxide and Endothelin Effects
- Neurotransmitter Receptor Influence on Behavior
- Pesticide Residue Analysis and Safety
- Erythrocyte Function and Pathophysiology
- Cell death mechanisms and regulation
- Eicosanoids and Hypertension Pharmacology
- Automotive and Human Injury Biomechanics
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Dermatological diseases and infestations
- Intracerebral and Subarachnoid Hemorrhage Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Trauma and Emergency Care Studies
Tohoku Medical and Pharmaceutical University
2017-2023
Tohoku Medical and Pharmaceutical University Hospital
2018-2019
National Archives and Records Administration
2018
Komatsu (Japan)
2018
Akina (United States)
2018
The University of Tokyo
2014-2016
Chiba University
2015-2016
Tokyo Medical and Dental University
2009-2014
Hypothyroidism is a condition characterised by the inadequate production of thyroid hormones; common endocrine disorder found worldwide. It affects approximately 2-5% global population and more prevalent in females. Ayurvedic texts do not explicitly mention hypothyroidism. Upon reviewing clinical presentations classical texts, it evident that hypothyroidism associated with imbalances Jatharagni Dhatwagni, along disturbances Kapha Vata Doshas. Additionally, there are abnormalities Rasavaha,...
In acute poisoning cases involving the ingestion of organophosphate insecticides such as fenitrothion and malathion, serum cholinesterase (ChE) activity is remarkably decreased, thus representing a useful indicator direct cause death. present case, man in his early 70s tried to committed suicide via oral both malathion. Fenitrothion malathion concentrations cardiac blood were 2.63–2.98 0.31–0.58 µg/mL, respectively. However, ChE level was 200 IU/L, which not considerably lower than normal...
Pulmonary arterial hypertension (PAH) is prevalent in patients with obstructive sleep apnea syndrome (OSAS). Aging induces arginase activation and reduces nitric oxide (NO) production the arteries. Intermittent hypoxia (IH), conferred by cycles of brief normoxia, contributes to OSAS pathogenesis. Here, we studied role aging pathogenesis PAH adult (9-mo-old) young (2-mo-old) male Sprague-Dawley rats subjected IH or normoxia for 4 weeks analyzed them a pressure-volume catheter inserted into...
Rhabdomyolysis is characterised by acute kidney injury (AKI) resulting from skeletal muscle injury. Lipid peroxidation-mediated oxidant and pro-inflammatory cytokine-mediated inflammatory response play critical roles in the pathogenesis of rhabdomyolysis-induced AKI. The present study aimed to investigate short-term effects both lipid peroxidation responses on AKI a rat model glycerol-induced rhabdomyolysis. was induced intramuscular injection 50% glycerol saline (10 mL/kg) into hind limbs...
Chronic intermittent hypoxia (IH) induces activation of the sympathoadrenal system, which plays a pivotal role in attenuating hypoxic pulmonary vasoconstriction (HPV) via central β1-adrenergic receptors (AR) (brain) and peripheral β2AR (pulmonary arteries). Prolonged hypercatecholemia has been shown to upregulate β3AR. However, relationship between IH β3AR modification HPV is unknown. It observed that chronic stimulation upregulates inducible nitric oxide synthase (iNOS) cardiomyocytes...
In sleep apnea syndrome (SAS), intermittent hypoxia (IH) induces repeated episodes of hypoxic pulmonary vasoconstriction (HPV) during sleep, which presumably contribute to arterial hypertension (PAH). However, the prevalence PAH was low and severity is mostly mild in SAS patients, or no right ventricular hypertrophy (RVH) reported IH-exposed animals. The question then arises as why not a universal finding if sufficient duration causes cycling HPV. present study, rats underwent IH at rate 3...
Pulmonary air embolisms due to the removal of a central venous catheter are rare, but is known be high risk factor for embolism. In particular, large catheter, such as double-lumen hemodialysis can allow amount enter into bloodstream, which often results in sudden death. So, during removal, special care should taken prevent from entering blood vessels, example, ensure that patient's head tilted downward, they have inhaled and holding their breath, covering gauze inert ointment been applied...
Abstract Fentanyl transdermal patches have been used to treat cancer‐ and noncancer‐related chronic pain. However, its inappropriate or illegal application may cause fatal poisoning. We herein present the case of a Japanese woman in her 40s who was found dead with seven 25‐μg/h fentanyl on body. established detailed toxicological analysis procedure quantify fentanyl, metabolite norfentanyl, other drugs (acetaminophen, allylisopropylacetylurea, celecoxib, estazolam, promethazine, sertraline)...
Abstract Organophosphates are widely used as pesticides. However, organophosphates occasionally orally ingested to commit suicide. In this case, a man in his late 80s committed suicide by ingesting both dichlorvos and phenthoate. Autopsy findings revealed characteristic volatile odor from mouth, stomach, lungs, liver, kidneys. The esophageal mucosa was denatured had lost elasticity. Serum cholinesterase activity 9 IU/L. Toxicological analyses performed using high‐performance liquid...
The potato glycoalkaloids (PGAs), α-solanine and α-chaconine can exert adverse effects on human health when consumed in excess. This study aimed to investigate the optimal extraction method for quantitative analysis of PGAs whole blood by using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) apply this validated postmortem blood.A total 200 µL was prepared PGA extraction. For validation, a solid-phase (SPE) Oasis® PRiME HLB, which could be performed three...
Cytokine storm-derived influenza-associated encephalopathy is a severe complication, affecting not only the brain but also multiple systemic organs including heart and lungs. Hundreds of Japanese children are afflicted by every year. Influenza-associated can be diagnosed pathological changes, such as advanced edema disruption astrocytic projections, which known clasmatodendrosis. In present case, despite absence significant histopathological findings in brain, diagnosis was made on basis...
2-Phenylethylamine (phenethylamine) and its derivatives are stimulant drugs, which prohibited in sports because of their potential performance-enhancing properties. If phenethylamine is detected an athlete's urine, the athlete may be subjected to serious sanctions, such as disqualification for both domestic international competitions. Given consequences athletes face detection, great care should taken avoid false positive tests. In forensic medicine, it widely known that produced by...
Background: Patient with Obstructive sleep apnea (OSA) exposed to chronic intermittent hypoxia (IH), which is thought be the underlying mechanism that links OSA cardiovascular disease. However, it remains unclear whether (IH) associated in vivo functional impairment coronary microvasculature.