Mineral nutrition is a major factor affecting plant growth and function. Increasing evidence supports the involvement of macro micronutrients in secondary metabolism. The use appropriate nutritional measures including organic fertilizers, supplements, biostimulants therefore vital aspect medicinal production medical cannabis. Due to legal restriction on cannabis research, very little information available concerning effects supplements physiological chemical properties cannabis, their...

Multiple sclerosis (MS) is a widespread chronic neuroinflammatory and neurodegenerative disease. Microglia play crucial role in the pathogenesis of MS via release cytokines reactive oxygen species, e.g., nitric oxide. Research involving phytocannabinoids neuroinflammation currently receiving much attention. Cannabigerol main phytocannabinoid, which has attracted significant pharmacological interest due to its non-psychotropic nature. In this research, we studied effects cannabigerol on...

Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome, which often includes obesity, diabetes, and dyslipidemia. Several studies in mice humans have implicated the involvement of gut microbiome NAFLD. While cannabis its phytocannabinoids may potentially be beneficial for treating disorders such as NAFLD, their effects on diseases microbiota profile yet to addressed. In this study, we evaluated therapeutic two major cannabinoids, delta-9-tetrahydrocannabinol (THC)...

Lilium candidum L., known as Madonna, meadow, or white lily, is a bulbous plant from the Liliaceae family, originating in Middle East. L. has been abundantly used folk medicine since ancient times to relieve variety of ailments, including age-related diseases, burns, ulcers, and coughs. The aim this article investigate anti-inflammatory anti-diabetic activities extracts its active phytochemicals. Some volatile phytochemicals were identified using gas chromatography-mass spectrometry (GC-MS)...

Introduction: Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndrome, which often includes obesity, diabetes, and dyslipidemia. Several studies in mice humans have implicated the involvement of gut microbiome NAFLD. While cannabis may potentially be beneficial for treating disorders such as NAFLD, effects on diseases microbiota profile are yet to addressed. In this study, we evaluated therapeutic strains different cannabinoid profiles NAFLD progression. Materials...

Dittrichia viscosa is a perennial Mediterranean plant used in traditional medicine for "calming purposes", pointing at possible antidepressant activity of the plant. We conducted chromatographic and bioassay-guided fractionation D. root extract to isolate specific fraction (fraction "K") with antidepressant-like characteristics vivo strong antioxidant properties vitro. A single dose "K" reduced immobility time forced swim test mouse model possessing depressive-like phenotype. Neurochemical...

Nutrition, especially wheat consumption, is a major factor involved in the onset of type 1 diabetes (T1D) and other autoimmune diseases such as celiac. While modern cultivars possess similar gliadin proteins associated with celiac disease T1D, alternative dietary sources from Israeli landraces native ancestral species may be lacking epitopes linked potentially reducing incidence T1D. The Non-Obese Diabetic (NOD) mouse model was used to monitor effects on development flour were compared those...

Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic abnormalities and has been linked with metabolic syndrome hallmarks. Unfortunately, current treatments are limited. This work aimed to elucidate the effects three cannabis extracts on alteration gut microbiota composition in mouse model NAFLD obesity. Male mice were fed high-fat diet (HFD) for 12 weeks. Following establishment obesity, HFD-fed group was subdivided into HFD or that supplemented one (CN1, CN2, CN6) additional...

Chiliadenus iphionoides (Asteraceae), a shrub endemic to the Mediterranean region and widespread throughout Israel, is used in traditional eastern medicine. Although recent research confirmed its pharmacological potential, C. essential oil has not been adequately characterized chemically. Essential-oil samples were collected from representative wild populations Israel by GC/MS analysis. Considerable interpopulation variation was found for composition of oils. Multivariate analysis showed...

Bacterial quorum sensing (QS) is a form of cell-to-cell communication which vital to the pathogenicity many bacteria, and therefore promising target for development new treatments microbial infections. While medicinal plants possess antibacterial activity, only few have been shown sensing. In face increased resistance existing antibiotics coupled with decline in novel antibiotic development, QS inhibitors from direction treatments,. The purpose this review summarize verified data on anti-QS...

While spinach is an established nutritionally important crop, its medicinal value not as well known. Spinach rich in ecdysteroids, insect hormone analogs with a number of properties including anti-oxidative, anti-inflammatory and even anabolic activity. However, the potential plant has yet been developed. In this study, ecdysteroid content was optimized to increase therapeutic value. seeds from various sources were grown under controlled hydroponic conditions analyzed for related Variations...

Abstract Introduction Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by neuroinflammation, demyelination and axonal loss. Cannabis, an immunomodulating agent, known for its ability to treat MS effectively. However, due variations in profile secondary metabolites, especially cannabinoids, among cannabis cultivars, effectiveness treatment can vary, with significant variability effects on different biological parameters. For screening...

Crude ethanolic extracts from Phlomis viscosa Poiret leaves the Judea region (Israel) are renowned for their remarkable geroprotective properties: anti-inflammatory, anti-diabetic, and anti-cancer. A phytochemical investigation carried out in this study revealed that tested plant might belong to a particular distinct chemotype because its phytochemicals different compounds were mentioned literature. Among identified by us was diosmin, synthetic derivatives of which further obtained...

Non-alcoholic fatty liver disease (NAFLD) has become an epidemic with increasing prevalence. Limited treatment options and poor adherence emphasize the urgent need for novel therapies and/or prevention of NAFLD. Bioactive natural compounds found in medicinal plants are promising as therapeutic agents Chiliadenus iphionoides, a plant several health-promoting properties, is encouraging candidate. The current study aimed to elucidate metabolic effects C. iphionoides consumption high-fat-diet...

Myrtus communis is a Mediterranean shrub cultivated in Israel for traditional, ceremonial use only, with more than 98 % of the crop biomass, equivalent to 26–27 tons per ha annum, considered agricultural waste. Therefore, potentially profitable this excess being highly sought. As also known its unique terpene and terpenoid content, work evaluated impact essential oil (EO) extracted from several M. cultivars on storage insects, nematodes, fungi, pathogens. In addition, allelopathic effect...

Buccal drug delivery offers a promising alternative for avoiding gastrointestinal degradation and first-pass metabolism. However, enhancing the buccal epithelial barrier’s permeability remains challenging. This study explores effects of ethanolic extracts from Citrus medica var. Balady (CM), Calabria (CMC), Origanum dayi (ORD) on epithelium in vitro using TR146 cell-based model. The cell viability assay revealed that were non-toxic at concentration range tested (<0.5% w/v). Surprisingly,...

Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the profile brains mice with strong characteristics social dominance submissiveness. Methods: A lipidomics approach was employed assess endocannabinoidome Dominant (Dom) Submissive (Sub) mice. showing greatest difference concentration brain between groups, docosatetraenoyl ethanolamine (DEA), synthesized, its effects on physiological...

Abstract Myrtus communis is a Mediterranean shrub cultivated in Israel for traditional, ceremonial use only, with more than 98% of the crop biomass, equivalent to 26–27 tons per ha annum, considered agricultural waste. Therefore, potentially profitable this excess being highly sought. As also known its unique terpene and terpenoid content, work evaluated impact essential oil (EO) extracted from several M. cultivars on storage insects, nematodes, fungi, pathogens. In addition, allelopathic...