A5089479209- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Biological and pharmacological studies of plants
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Geology and Paleoclimatology Research
- Traditional Chinese Medicine Analysis
- Plant chemical constituents analysis
- Geological formations and processes
- Ectopic Pregnancy Diagnosis and Management
- Urological Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Personality Disorders and Psychopathology
- Nanocluster Synthesis and Applications
- Ziziphus Jujuba Studies and Applications
- ECG Monitoring and Analysis
- Bladder and Urothelial Cancer Treatments
- Psychosomatic Disorders and Their Treatments
- Cardiac electrophysiology and arrhythmias
- Colorectal Cancer Surgical Treatments
- Plant and animal studies
- Pancreatitis Pathology and Treatment
Shenyang 242 Hospital
2024
Guangzhou Medical University
2022-2024
Chengdu University of Traditional Chinese Medicine
2012-2024
Jinan City People's Hospital
2016-2023
Shandong First Medical University
2016-2023
Tongji University
2023
Chengdu University
2020
Taishan Medical University
2019
University of California, Los Angeles
2019
Chongqing University
2012
This white paper presents principles for validating proarrhythmia risk prediction models regulatory use as discussed at the In Silico Breakout Session of a Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/US Food Drug Administration–sponsored Think Tank Meeting on May 22, 2018. The meeting was convened to evaluate progress in development new cardiac safety paradigm, Comprehensive Vitro Proarrhythmia Assay (CiPA). opinions regarding these reflect collective views...
Background: To assess the prevalence and risk factors of NAFLD in non-obese patients with schizophrenia a public psychiatric hospital China. Methods: A total 1,305 adult inpatients 2019 were included this retrospective study. Body mass index (BMI) ≥ 25 kg/m 2 was considered obese, BMI < non-obese. We obtained data from electronic records Affiliated Brain Hospital Guangzhou Medical University. Results: 1,045 260 obese The 25.0%, it much lower that (25.0% vs 64.6%, p 0.001). Among patients,...
Accumulating evidence suggests that aberrant expression of microRNAs (miRNAs) is involved in several diseases, including cancer. This study aimed to investigate the miRNA pattern and its alteration following celecoxib intervention for human colorectal cancer (CRC). The profiles CRC tissues, matched adjacent normal mucosae HT-29 cells treated with were determined using microarray, further confirmed quantitative reverse transcription-polymerase chain reaction (Q-RT-PCR). target genes miRNAs...
Efficient RNA isolation is a prerequisite to elucidate the molecular mechanisms of peimine metabolism in medicinal plant Fritillaria unibracteata, rare and famous region drug Sichuan, China. Three different methods were tested: modified SDS acid phenol, CTAB SDS-LiCl. Compared with SDS-LiCl methods, method phenol would obtain initial, abundant high-quality intact from F. unibracteata. Meanwhile, RNA-containing bands are clear light, lightness 28S rRNA two times than 18S rRNA. The ratio...
The aim of the present study was to investigate association between platelet microRNA-96 (miR-96) expression levels and occurrence deep vein thrombosis (DVT) in orthopedic patients. A total consecutive 69 patients with DVT 30 healthy individuals were enrolled. Ultrasonic color Doppler imaging performed on lower limb veins after surgery determine DVT. An enzyme-linked fluorescent assay detect D-dimer plasma. quantitative polymerase chain reaction miR-96. Expression miR-96 significantly...
Angelica anomala Avé-Lall (Chuanbaizhi in Chinese) is an important medicinal plant which can be used traditional Chinese medicines; however, there are no authentic and universal methods to differentiate this Sichuan famous-region drug of A. from a large number non-famous-region false drugs. It has been demonstrated that DNA barcoding molecular diagnostic method for species identification, uses single standardized fragment. In study, we tested five candidates (matK, ITS, ITS2, rbcL,...
BackgroundAbnormal functional connectivity (FC) in the brain has been observed schizophrenia patients. However, studies on FC between homotopic regions are limited, and results of these inconsistent. The aim this study was to compare first-episode (FES) patients healthy subjects assess its correlation with clinical symptoms.MethodsThirty-one FES thirty-three controls (HC) were included study. voxel-mirrored (VMHC) method resting-state magnetic resonance imaging (rs-fMRI) used analyse changes...
This study aimed to develop and internally validate a prediction model for estimating the risk of spontaneous abortion in early pregnancy.
Nuclear ribosomal DNA (nrDNA) targets, especially internal transcribed spacers (ITS) ITS1 and ITS2, have been widely used for molecular identification of some plants. We therefore, conducted an investigation in the the Angelica anomala cultivars collected Sichuan using ITS universal primers. About 700 bp fragments were initially obtained from famous-region drugs sample Zhongji village, Chuanshan County (ZJCS), depending on sequence ZJCS, results suggested that 7 samples are drugs, but others...
In recent years, graphene oxide quantum dots (GOQDs) have emerged as novel nanomaterials for optical sensing, bioimaging, clinical testing, and environmental testing. However, GOQDs demonstrate unique photoluminescence properties, with having limitations edge effects that often affect the accuracy of test results in sensory field. Herein, a large content hydroxyl groups low fluorescence intensity were first prepared via an improved Fenton reaction this study, which introduces amount epoxy to...
Bone tumor is a rare heterogeneous malignancy. Osteosarcoma the most common bone with no apparent underlying pathogenesis, and its peak incidence often occurs during puberty. The intensive application of chemotherapy rarely alters poor prognosis patients in advanced stage. Despite clinical practice, still suffer from prognosis, or even progression tumor. We identified integrin-associated protein (IAP) Cluster Differentiation 47 (CD47) as target for monoclonal antibody, use anti-CD47 antibody...
Prostate Cancer Associated 3 (PCA3) as a promising biomarker to replace serum prostate-specific antigen (PSA) for differential diagnosis of benign and malignant prostate diseases. However, the detection PCA3 in urine requires collection digital rectal examination (DRE) urine, which limits application screening In present study, new reverse transcription quantitative real-time polymerase chain reaction (qRT-PCR) method was developed non-DRE urine. The uses nanomaterial Graphene oxide (GO)...
Abstract As an important plateau cereal crop, hulless barley is the principal food for Tibetan people in China. ADP-glucose pyrophosphorylase (AGPase) considered as key enzyme starch biosynthesis plants. In this study, cDNAs encoding small subunit (SSU I) and large (LSU of AGPase were isolated from barley. The results showed that SSU I LSU 1438 1786 bp length with a complete open reading frame (ORF) 1419 1572 bp. ORF-encoded polypeptides 472 523 amino acids having calculated molecular masses...
matrix metalloproteunase, MMP)降解基质胶(胞外基质)是肿瘤细胞进行侵袭的 关键步骤之一.细胞坏死因子(tumor necrosis factor-α, TNF-)能够诱导乳腺肿瘤细胞(MDA-MB-231)分泌 MMP9, 从而提高肿瘤发生 [
Objective To explore the efficacy and safety of laparoscopic enucleation subserosal bladder leiomyoma. Methods The clinical data 8 patients with leiomyoma (5 male 3 female) from September 2010 to November 2016 were retrospectively analyzed. The age was 31-65 (mean 47±10) years. Clinical manifestation included irritative cases, hypogastralgia 2 cases no symptoms cases. Ultrasonography CT Urography (CTU) performed in all course disease ranged 1 week years 21 months), Routine urines...
Objective To evaluate the safety of total proctocolectomy (TPC) + ileal pouch anal anastomosis (IPAA) and postoperative sexual function in ulcerative colitis (UC) patients. Methods Clinical data UC patients undergoing TPC+IPAA from March 2011 to January 2018 our hospital were retrospectively collected. Postoperative follow-up ended June 2018. Patients divided into subgroups according whether developing complications, disorder (incontinence or defecation >8 times/d) (disorder erection,...