A5076010626- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Cardiovascular Health and Disease Prevention
- Gene Regulatory Network Analysis
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Heart Failure Treatment and Management
- Bioinformatics and Genomic Networks
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Elasticity and Material Modeling
- Mechanical Circulatory Support Devices
- Esophageal and GI Pathology
- Cardiomyopathy and Myosin Studies
- Liver Disease and Transplantation
- Enhanced Oil Recovery Techniques
- Scientific Computing and Data Management
- Cardiac Imaging and Diagnostics
- Gallbladder and Bile Duct Disorders
- Pulmonary Hypertension Research and Treatments
- Cellular Mechanics and Interactions
- Reservoir Engineering and Simulation Methods
University of Michigan
2016-2025
Touro University Nevada
2024
Valley Hospital Medical Center
2019-2024
Michigan United
2018-2024
Vanderbilt University Medical Center
2004-2024
Essentia Health
2024
BJC HealthCare
2024
Middle East Institute
2023
National Nuclear Security Administration
2023
RAND Corporation
2023
The autoregulation of blood flow, the maintenance almost constant flow in face variations arterial pressure, is characteristic many tissue types. Here, contributions to pressure-dependent, shear stress-dependent, and metabolic vasoactive responses are analyzed using a theoretical model. Seven segments, connected series, represent classes vessels: arteries, large arterioles, small capillaries, venules, veins. arterioles respond actively local changes pressure wall stress downstream state...
A proposed mechanism for metabolic flow regulation involves the saturation-dependent release of ATP by red blood cells, which triggers an upstream conducted response signal and arteriolar vasodilation. To analyze this mechanism, a theoretical model is used to simulate variation oxygen levels along pathway seven representative segments, including two vasoactive segments. The defined integrating concentration vascular pathway, assuming exponential decay in direction with length constant ∼1 cm....
ABSTRACT Objective: A theoretical model is developed to describe the myogenic response of resistance vessels changes in intravascular pressure, based on a consideration active and passive length–tension characteristics vascular smooth muscle (VSM). The dependence parameters vessel diameter examined. Methods: wall represented mechanically as nonlinear component parallel with an contractile component. level VSM tone assumed have sigmoidal circumferential tension or stress. Model are optimized...
Biological researchers increasingly rely on computational models to integrate biological systems knowledge, test hypotheses, and forecast system behavior.The expanding size of these requires solutions for managing their complexity.Modularity, a time-tested design principle complexity, can be applied within the modeling field parallelize work, automate composition, promote effective model sharing.As modelers complex systems, we aim apply modular production accelerate our efforts have...
Heart failure (HF) is a highly heterogeneous condition, and current methods struggle to synthesize extensive clinical data for personalized care. Using from 343 HF patients, we developed mechanistic computational models of the cardiovascular system create digital twins. These twins, consisting optimized measurable unmeasurable parameters alongside simulations function, provided comprehensive representations individual disease states. Unsupervised machine learning applied twin-derived...
It has become increasingly evident that the descriptions of many complex diseases are only possible by taking into account multiple influences at different physiological scales. To do this with computational models often requires integration several have overlapping scales (genes to molecules, molecules cells, cells tissues). The Virtual Physiological Rat (VPR) Project, a National Institute General Medical Sciences (NIGMS) funded Center Systems Biology, is tasked mechanistically describing...
Investment in human experience is imperative for healthcare organizations. It a strategic focus that can lead to great benefits. Those overlook experience, seeing it as "simply" about satisfaction or survey data, do so at cost their organization, team members, and most importantly those we serve – patients. A commitment integrating the patient, workforce, community essential all organizations realizing goals they strive impact aspire achieve. leads high-quality outcomes care for. creates...
Cardiomyocytes continuously experience mechanical stimuli that regulate their contractile behavior and contribute to overall heart function. Despite the importance of mechanotransduction in cardiac physiology, mechanisms by which cardiomyocytes integrate external cues, such as stretch environmental stiffness, remain poorly understood. In this study, we present a combined theoretical experimental framework investigate how strain-induced cytoskeletal stiffening modulates cardiomyocyte...
Over the past few years, Midwest Independent Transmission System Operator, Inc. (MISO) has transformed electric utility industry in 13 Midwestern US states through development and implementation of energy ancillary services markets. MISO uses mixed-integer programming to determine when each power plant should be on or off. Operations research methods set output levels establish prices at which trades. These new markets increased efficiency existing infrastructure (power plants transmission...
Reduced glomerular filtration, hypertension and renal microvascular injury are hallmarks of chronic kidney disease, which has a global prevalence ~10%. We have shown previously that the Fischer (F344) rat lower GFR than Lewis rat, is more susceptible to induced by hypertension. In early stages this limited pre-glomerular vasculature. hypothesized poor hemodynamic function vulnerability vascular causally linked genetically determined. present study, normotensive F344 rats had blunted pressure...
Abstract To phenotype mechanistic differences between heart failure with reduced (HFrEF) and preserved (HFpEF) ejection fraction, a closed‐loop model of the cardiovascular system coupled patient‐specific transthoracic echocardiography (TTE) right catheterization (RHC) data was used to identify key parameters representing haemodynamics. Thirty‐one patient records (10 HFrEF, 21 HFpEF) were obtained from Cardiovascular Health Improvement Project database at University Michigan. Model...
Ureteropelvic junction obstruction may either worsen and require surgery, improve or remain stable. It take upward of 3 years for the natural history to unfold. Urinary proteome analysis using capillary electrophoresis mass spectrometry has been shown differentiate between normal infants those with ureteropelvic obstruction. We sought confirm these findings liquid chromatography/nano-spray examine urinary in patients unilateral grade IV compared age matched healthy infants.Urine specimens...
The asserted dominant role of the kidneys in chronic regulation blood pressure and etiology hypertension has been debated since 1970s. At center theory is observation that acute relationships between arterial urine production—the pressure-diuresis pressure-natriuresis curves—physiologically adapt to perturbations and/or changes rate salt volume intake. These adaptations, modulated by various interacting neurohumoral mechanisms, result water excretion are much steeper than relationships....
<ns4:p>The asserted dominant role of the kidneys in chronic regulation blood pressure and etiology hypertension has been debated since 1970s. At center theory is observation that acute relationships between arterial urine production—the pressure-diuresis pressure-natriuresis curves—physiologically adapt to perturbations and/or changes rate salt volume intake. These adaptations, modulated by various interacting neurohumoral mechanisms, result water excretion are much steeper than...
Semantics-based model composition is an approach for generating complex biosimulation models from existing components that relies on capturing the biological meaning of elements in a machine-readable fashion. This allows user to work at rather than computational level abstraction and helps minimize amount manual effort required composition. To support this compositional approach, we have developed SemGen software, here report SemGen’s semantics-based merging capabilities using real-world...
Mathematics and Phy sics-based simulation models have the potential to help interpret encapsulate biological phenomena in a computable reproducible form. Similarly, comprehensive descriptions of such ensure that are accessible, discoverable, reusable. To this end, researchers developed tools standards encode mathematical systems enabling reproducibility reuse, guidelines facilitate semantic description models, repositories which archive, share, discover models. Scientists can leverage these...
A computer model was used to analyze data on cardiac and vascular mechanics from C57BL6/J mice exposed 0 (n = 4), 14 6), 21 8) 28 7) days of chronic hypoxia treatment with the VEGF receptor inhibitor SUGEN (HySu) induce pulmonary hypertension. Data right ventricular pressure volume, systemic arterial obtained before, during, after inferior vena cava occlusion were analyzed using a mathematical realistic coupled simple systems. The invokes total 26 adjustable parameters, which estimated based...
Abstract Summary As the number and complexity of biosimulation models grows, so do demands for tools that can help users understand compose more comprehensive accurate systems from existing models. SemGen is a tool semantics-based annotation composition designed to address this demand. A key capability decompose then integrate across model exchange formats including SBML CellML. To support capability, we use semantic annotations explicitly capture underlying biological physical meanings...
Abstract Maintaining proper waterflood conformance is a critical component of management. Most methods used to control have proven be only marginally effective. A unique technique has been developed for creating durable reservoir flow restriction that diverts injected water into unswept sections. Placement the based in location thermal front between injector and producers. The performance this thermally activated particulate system evaluated three injection well trial Prudhoe Bay oilfield,...
Microcirculatory vessel response to changes in pressure, known as the myogenic response, is a key component of tissue's ability regulate blood flow. Experimental studies have not clearly elucidated mechanical signal wall governing steady-state reduction diameter upon an increase intraluminal pressure. In this study, multiscale computational model constructed from established models mechanics, vascular smooth muscle (VSM) force generation, and VSM Ca 2+ handling electrophysiology compare...