A5078997622- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Diet, Metabolism, and Disease
- Signaling Pathways in Disease
- Liver Disease Diagnosis and Treatment
- Mosquito-borne diseases and control
- Diet and metabolism studies
- Cell death mechanisms and regulation
- Lipid metabolism and disorders
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Regulation of Appetite and Obesity
- Autoimmune and Inflammatory Disorders Research
- Adipokines, Inflammation, and Metabolic Diseases
- Peptidase Inhibition and Analysis
- Advanced Fluorescence Microscopy Techniques
- S100 Proteins and Annexins
- Immune cells in cancer
- Cholesterol and Lipid Metabolism
- Clusterin in disease pathology
- Anesthesia and Neurotoxicity Research
- Spaceflight effects on biology
- Nuclear Receptors and Signaling
- Immune Response and Inflammation
- Lysosomal Storage Disorders Research
Biomedical Research and Innovation Institute of Cadiz
2023-2024
Instituto de Investigación Biomédica de A Coruña
2023-2024
University of Lisbon
2024
Universidad de Cádiz
2024
Instituto de Biomedicina y Genética Molecular de Valladolid
2018-2023
Universidad de Valladolid
2018-2023
Alzheimer's disease (AD), the leading cause of dementia, is a multifactorial influenced by aging, genetics, and environmental factors. miRNAs are crucial regulators gene expression play significant roles in AD onset progression. This exploratory study analyzed levels 28 genes 5 (miR-124-3p, miR-125b-5p, miR-21-5p, miR-146a-5p, miR-155-5p) related to pathology neuroimmune responses using RT-qPCR. Analyses were conducted prefrontal cortex (PFC) hippocampus (HPC)
The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE able to cleave many substrates vitro, including amyloid beta peptides, making this a candidate pathophysiological link between Alzheimer's disease (AD) and type 2 diabetes (T2D). These antecedents led us address impact of absence hippocampus olfactory bulb. A induction microgliosis was...
Lysosomal Storage Diseases (LSD) are genetic diseases causing systemic and nervous system dysfunction. The glia-derived lipid binding protein Apolipoprotein D (ApoD) is required for lysosomal functional integrity in glial neuronal cells, ensuring cell survival upon oxidative stress or injury. Here we test whether ApoD counteracts the pathogenic consequences of a LSD, Niemann Pick-type-A disease (NPA), where mutations acid sphingomyelinase gene result sphingomyelin accumulation,...
The insulin-degrading enzyme (IDE) is a zinc-dependent metalloendopeptidase that belongs to the M16A metalloprotease family. IDE markedly expressed in brain, where it particularly relevant due its vitro amyloid beta (Aβ)-degrading activity. subcellular localization of IDE, paramount aspect understand how this can perform proteolytic functions vivo, remains highly controversial. In work, we addressed from an evolutionary perspective. Phylogenetic analyses based on protein sequence and gene...
Accumulated evidence points to the lipocalin apolipoprotein D (ApoD), one of few genes consistently upregulated upon brain ageing and neurodegeneration, as an endogenous controller redox state cellular extracellular lipid structures. This biochemical function has downstream consequences apparently varied control glycocalyx myelin compaction, cell viability oxidative stress or modulation signalling pathways. In spite this knowledge, it is still unclear if ApoD requires canonical...
Microglial cells are recognized as very dynamic brain cells, screening the environment and sensitive to signals from all other cell types in health disease. Apolipoprotein D (ApoD), a lipid-binding protein of Lipocalin family, is required for nervous system optimal function proper development maintenance key neural structures. ApoD has state-dependent expression healthy system, increases its upon aging, damage or neurodegeneration. An extensive overlap exists between processes where involved...
Neurodegenerative diseases are age-related disorders caused by progressive neuronal death in different regions of the nervous system. Neuroinflammation, modulated glial cells, is a crucial event during neurodegenerative process; consequently, there an urgency to find new therapeutic products with anti-glioinflammatory properties. Five furanocembranolides (1−5), along leptolide, were isolated from two extracts Leptogorgia sp., and compound 6 was obtained chemical transformation leptolide....