A5057874834- Planarian Biology and Electrostimulation
- Marine Ecology and Invasive Species
- Spinal Cord Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Plant and Biological Electrophysiology Studies
- Spaceflight effects on biology
- Marine Invertebrate Physiology and Ecology
- Cerebral Palsy and Movement Disorders
- Nerve injury and regeneration
- Botulinum Toxin and Related Neurological Disorders
- Anesthesia and Neurotoxicity Research
- Sarcoma Diagnosis and Treatment
- Barrier Structure and Function Studies
- Stroke Rehabilitation and Recovery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Ovarian cancer diagnosis and treatment
- Cephalopods and Marine Biology
- Cancer Diagnosis and Treatment
- Uterine Myomas and Treatments
- Clinical Reasoning and Diagnostic Skills
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Dysraphism and Malformations
- Amyotrophic Lateral Sclerosis Research
University of Minho
2005-2025
Hospital Braga
2021-2023
Clinical Academic Center of Braga
2018-2022
Universidade Nova de Lisboa
2019-2021
Universitat de Barcelona
2017-2020
Institut de Biomedicina de la Universitat de Barcelona
2017-2018
Background and Purpose Spinal cord injury (SCI) is a neurological condition that affects motor sensory functions below the site. The consequences of SCI are devastating for patients, although significant efforts have been done in last years, there no effective therapy. Baclofen has emerged few years as an interesting drug field. Already used clinical setting to control spasticity, baclofen shown important impact on recovery animal models, such lampreys mice. Experimental Approach Key Results...
O presente estudo revisou os desafios no tratamento da síndrome coronariana aguda em pacientes plaquetopênicos, utilizando uma abordagem de revisão integrativa. objetivo foi explorar principais clínicos e terapêuticos manejo com plaquetopenia.. A metodologia consistiu integrativa realizada nas bases dados Scientific Electronic Library Online (SCIELO), Cochrane Medline, descritores ciências saúde relacionados ao tema, como “Acute Coronary Syndrome”, “Blood Platelet Disorders” “Patient Care...
The Hippo pathway plays a key role in regulating cell turnover adult tissues, and abnormalities this are consistently associated with human cancers. was initially implicated the control of proliferation death, its inhibition is linked to expansion stem cells progenitors, leading larger organ size tumor formation. To understand mechanism by which directs renewal promotes stemness, we studied function planarians. These cell–based organisms ideal models for analysis complex cellular events...
Neutrophils are prominent immune components of tumors, having either anti-tumor (N1) or pro-tumor activity (N2). Circulating neutrophils, divided into high density neutrophils (HDN) and low (LDN), functionally mirror those N1 N2 cells, respectively. LDN rare in non-pathological conditions, but frequent cancer, exhibiting a phenotype. These findings have been mainly demonstrated animal models, thus proper validation humans is still imperative. Here, we observed that were increased the blood...
ABSTRACT Control of cell number is crucial to define body size during animal development and restrict tumoral transformation. The determined by the balance between proliferation death. Although many genes are known regulate those processes, molecular mechanisms underlying relationship remain poorly understood. This can be better understood studying planarians, flatworms that continuously change their according nutrient availability. We identified a novel gene family, blitzschnell (bls),...
How adult stem cells differentiate into different cell types remains one of the most intriguing questions in regenerative medicine. Pioneer factors are transcription that can bind to and open chromatin, among first elements involved differentiation. We used freshwater planarian Schmidtea mediterranea as a model system study role gata456 family pioneer gut differentiation during both regeneration maintenance digestive system. Our findings reveal presence two members genome; Smed-gata456-1...
Introduction The inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at SCI site favors macrophage polarization into pro-inflammatory phenotype, which one reasons why transplantation has failed. Methods In this study, we investigated therapeutic potential secretome for recovery. We effect in vitro using peripheral and CNS-derived neurons human...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with short life expectancy and no effective therapy. We previously identified upregulated miR-124 in NSC-34-motor neurons (MNs) expressing human SOD1-G93A (mSOD1) established its implication mSOD1 MN degeneration glial cell activation. When anti-miR-124-treated (preconditioned) secretome was incubated spinal cord organotypic cultures from symptomatic mice, the dysregulated homeostatic balance circumvented. To decipher...
To assess the interobserver-reality agreement on ovarian cancer staging, when true-status of examined locations is known after pathology or subsequent response to neoadjuvant treatment. This study included 25 reviewers with variable experience (13 highly vs. 12 less experienced, at least 6 months training in a specialised centre) ultrasound staging. Each observer evaluated 380 videoclips from 4 compartments (upper and middle abdomen, pelvis lymph nodes), including 19 anatomical sites 5...
In the last years, planarians have emerged as a unique model animal for studying regeneration and stem cells biology. Although their remarkable regenerative abilities are known long time, only recently molecular tools to understand biology of planarian fundamentals process been established. This boost is due availability sequenced genome development new technologies, such interference RNA next-generation sequencing, which facilitate studies at genetic level. For these reasons, maintain...
Abstract Although many examples of simulated and real microgravity demonstrating their profound effect on biological systems are described in literature, few reports deal with hypergravity vibration effects, the levels which severely increased during launch preceding desired period. Here, we used planarians, flatworms that can regenerate any body part a days. Planarians an ideal model to study impact launch-related regenerative process “whole animal” context. Therefore, planarians were...
The possibility of humans to live outside Earth on another planet has attracted the attention numerous scientists around world. One greatest difficulties is that cannot in an extra-Earth environment without proper equipment. In addition, consequences chronic gravity alterations human body are not known. Here, we used planarians as a model system test how fluctuations could affect complex organisms. Planarians ideal system, since they can regenerate any missing part and continuously renewing...
Regional heterogeneity of microglia was first described a century ago by Pio del Rio Hortega. Currently, new hints on across central nervous system (CNS) regions are still being unraveled high-throughput techniques. It remains unclear whether these spatial specificities translate into different microglial behaviors in vitro. We cultured isolated from the cortex and spinal cord analyzed effect CNS source vitro behavior applying same experimental protocol culture conditions. cell numbers,...
Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can after compression mice [1]. Here, we provide transcriptomic (RNA-seq) data adult mouse spinal cords collected 7 days and (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used generate the raw data. In addition, also present bioinformatic...
Abstract Neutrophils are prominent immune components of solid tumors, which can protect against the onset cancer (N1) or have pro-tumor activity (N2). Circulating neutrophils, divided into high density neutrophils (HDN) and low (LDN), functionally mirror those N1 N2 cells, respectively. LDN, a rare subset in non-pathological conditions, been extensively studied cancer, due to their frequency this disease phenotype. However, has mainly demonstrated animal models proper validation humans is an...
Planarians are freshwater flatworms, well known for their ability to regenerate a complete organism from any piece of body.Furthermore, planarians constantly growing and degrowing throughout lives, maintaining functional proportioned body.These properties rely on the presence population adult stem cells tight control cell renewal, which is based balance between proliferation new differentiation, death unnecessary cells.Due importance these two processes in planarian biology, over years,...
To describe the clinical and sonographic characteristics of benign, retroperitoneal, pelvic peripheral nerve sheath tumours (PNST). A retrospective, single, gynecologic oncology centre study conducted between 1/1/2018 31/8/2022. All ultrasound images, clips, final specimens benign PNSTs were reviewed to describe: (1) appearance using standardised terminology, (2) origin in relation nerves anatomy, (3) correlation features histotopograms. Five women (mean 53yr) with solitary identified: four...
The regional heterogeneity of microglia was first described a century ago by Pio del Rio Hortega. Currently, new information on throughout central nervous system (CNS) regions is being revealed high-throughput techniques. It remains unclear whether these spatial specificities translate into different microglial behaviors in vitro. We cultured isolated from the cortex and spinal cord analyzed effect CNS source behavior vitro applying same experimental protocol culture conditions. cell...