A5057348159- Spinal Cord Injury Research
- Nerve injury and regeneration
- Cerebral Palsy and Movement Disorders
- Stroke Rehabilitation and Recovery
- RNA Interference and Gene Delivery
- Mesenchymal stem cell research
- Parkinson's Disease Mechanisms and Treatments
- Spinal Dysraphism and Malformations
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Peroxisome Proliferator-Activated Receptors
- Tissue Engineering and Regenerative Medicine
- Advanced Memory and Neural Computing
- Conducting polymers and applications
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
University of Minho
2021-2025
Parkinson's disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion still one most widely used techniques for modeling rodents. Despite commonly rats, it can be challenging to reproduce similar mice. Moreover, there lack characterization extent behavioral deficits and neuronal loss/neurotransmitter system unilateral mouse models. In this study, we present an...
Background and Purpose Spinal cord injury (SCI) is a neurological condition that affects motor sensory functions below the site. The consequences of SCI are devastating for patients, although significant efforts have been done in last years, there no effective therapy. Baclofen has emerged few years as an interesting drug field. Already used clinical setting to control spasticity, baclofen shown important impact on recovery animal models, such lampreys mice. Experimental Approach Key Results...
Introduction The inflammatory response after spinal cord injury (SCI) is an important contributor to secondary damage. Infiltrating macrophages can acquire a spectrum of activation states, however, the microenvironment at SCI site favors macrophage polarization into pro-inflammatory phenotype, which one reasons why transplantation has failed. Methods In this study, we investigated therapeutic potential secretome for recovery. We effect in vitro using peripheral and CNS-derived neurons human...
Priming strategies that improve the functionality of MSCs may be required to address issues limiting successful clinical translation MSC therapies. For conditions requiring high trophic support such as brain and spinal cord injuries, priming produce higher levels factors instrumental facilitate current We developed tested a novel molecular paradigm using docosahexaenoic acid (DHA) prime adipose tissue-derived mesenchymal stromal cells (ASCs) enhance secretome neuroregulatory potential.
Polyimide is an emerging and very interesting material for substrate passivation of neural probes. However, the standard curing temperature polyimide (350 °C) critical microelectrodes contact pads probe, due to thermal oxidation metals during process probe. Here, fabrication a flexible enhanced with photosensitive low-temperature cured polyimide, presented. Annealing tests were performed metallic films deposited on which led reduction 250 °C, no significant irregularities in sample annealed...
Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can after compression mice [1]. Here, we provide transcriptomic (RNA-seq) data adult mouse spinal cords collected 7 days and (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used generate the raw data. In addition, also present bioinformatic...