A5018806344- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Birth, Development, and Health
- Sleep and Wakefulness Research
- Epigenetics and DNA Methylation
- Cannabis and Cannabinoid Research
- Neurotransmitter Receptor Influence on Behavior
- Axon Guidance and Neuronal Signaling
- Nuclear Receptors and Signaling
- Tryptophan and brain disorders
- ATP Synthase and ATPases Research
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Neonatal Respiratory Health Research
- Parkinson's Disease Mechanisms and Treatments
- Memory and Neural Mechanisms
- Hormonal Regulation and Hypertension
- Neonatal and fetal brain pathology
- Sexual Differentiation and Disorders
- Conducting polymers and applications
- Photoreceptor and optogenetics research
- Mediterranean and Iberian flora and fauna
University of Minho
2016-2024
University of Lisbon
2023
Weatherford College
2023
The University of Adelaide
2023
University of Amsterdam
2023
Instituto de Medicina Molecular João Lobo Antunes
2023
Deficits in decoding rewarding (and aversive) signals are present several neuropsychiatric conditions such as depression and addiction, emphasising the importance of studying underlying neural circuits detail. One key regions reward circuit is nucleus accumbens (NAc). The classical view on field postulates that NAc dopamine receptor D1-expressing medium spiny neurons (D1-MSNs) convey signals, while D2-expressing MSNs (D2-MSNs) encode aversion. Here, we show both MSN subpopulations can drive...
Abstract Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of recovery from depression. Nevertheless, high number remitted patients experience episodes depression, remaining unclear how previous impact on behavior neuroplasticity and/or whether modulation important prevent Through re-exposure an unpredictable chronic mild stress...
Parkinson's disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion still one most widely used techniques for modeling rodents. Despite commonly rats, it can be challenging to reproduce similar mice. Moreover, there lack characterization extent behavioral deficits and neuronal loss/neurotransmitter system unilateral mouse models. In this study, we present an...
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in pathophysiology depression as modulators neurotransmission and neurovascular coupling. This evidenced by astrocyte impairments observed brains depressed patients appearance depressive-like behaviors upon astrocytic dysfunctions animal models. However, little known about importance de novo generated mammalian brain particular its possible involvement precipitation...
Parkinson’s disease (PD) is the most common movement disorder, characterized by progressive loss of dopaminergic neurons from nigrostriatal system. Currently, there no treatment that retards progression or reverses damage prior to time clinical diagnosis. Mesenchymal stem cells (MSCs) are one extensively studied cell sources for regenerative medicine applications, particularly due release soluble factors and vesicles, known as secretome. The main goal this work was address therapeutic...
Abstract Chronic stress is a major risk factor for neuropsychiatric conditions such as depression. Adult hippocampal neurogenesis (AHN) has emerged promising target to counteract stress-related disorders given the ability of newborn neurons facilitate endogenous plasticity. Recent data sheds light on interaction between cannabinoids and neurotrophic factors underlying regulation AHN, with important effects cognitive plasticity emotional flexibility. Since physical exercise (PE) known enhance...
Astrocytes are key players in the regulation of brain development and function. They sense respond to surrounding activity by elevating their intracellular calcium (Ca2+ ) levels. These astrocytic Ca2+ elevations emerge from different sources display complex spatio-temporal properties. spatially distributed global (soma main processes) and/or focal regions (microdomains). The inositol 1,4,5-trisphosphate receptor type 2 knockout (IP3 R2 KO) mouse model lacks astrocytes, it has been used...
A correction to this paper has been published and can be accessed via a link at the top of paper.
Abstract Objectives The action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to stressful events. HPA axis activity is predicated on information processing modulation by upstream centres, such as hippocampus where adult‐born neurons (hABN) have been reported be an important component in integration new information. Still, it remains unclear whether how hABN regulates CORT production, particularly when considering sex differences. Materials Methods...
The transcription factor activating protein two gamma (AP2γ) is an important regulator of neurogenesis both during embryonic development as well in the postnatal brain, but its role for neurophysiology and behavior at distinct periods still unclear. In this work, we explored neurogenic, behavioral, functional impact a constitutive heterozygous AP2γ deletion mice from early until adulthood. deficiency promotes downregulation hippocampal glutamatergic neurogenesis, altering ontogeny emotional...
Abstract Chronic stress is a major risk factor of neuropsychiatric conditions such as depression. Adult hippocampal neurogenesis (AHN) has emerged promising target to counteract stress-related disorders given the ability newborn neurons facilitate endogenous plasticity. Recent data sheds light on interaction between cannabinoids and neurotrophic factors underlying regulation AHN, with important effects upon cognitive plasticity emotional flexibility. Since physical exercise (PE) known...
Abstract Chronic stress is a major risk factor of neuropsychiatric conditions such as depression. Adult hippocampal neurogenesis (AHN) has emerged promising target to counteract stress-related disorders given the ability newborn neurons facilitate endogenous plasticity. Recent data sheds light on interaction between cannabinoids and neurotrophic factors underlying regulation AHN, with important effects upon cognitive plasticity emotional flexibility. Since physical exercise (PE) known...