A5029110992- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Axon Guidance and Neuronal Signaling
- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Pharmacological Effects and Toxicity Studies
- Anesthesia and Neurotoxicity Research
- Preterm Birth and Chorioamnionitis
- Perovskite Materials and Applications
- Chemical synthesis and alkaloids
- Neonatal Respiratory Health Research
- Hormonal Regulation and Hypertension
- Neurotransmitter Receptor Influence on Behavior
- Forensic Anthropology and Bioarchaeology Studies
- Neonatal and fetal brain pathology
- Quantum Dots Synthesis And Properties
- Diet and metabolism studies
- Sexual Differentiation and Disorders
- Olfactory and Sensory Function Studies
- Pain Mechanisms and Treatments
University of Minho
2014-2022
Abstract Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of recovery from depression. Nevertheless, high number remitted patients experience episodes depression, remaining unclear how previous impact on behavior neuroplasticity and/or whether modulation important prevent Through re-exposure an unpredictable chronic mild stress...
Measuring anhedonic behavior in rodents is a challenging task as current methods display only moderate sensitivity to detect phenotype and, consequently, results from different labs are frequently incongruent. Herein we present newly-developed test, the Sweet Drive Test (SDT), which integrates food preference measurement non-aversive environment, with ultrasonic vocalizations (USVs) recording. Animals were placed soundproofed black arena, under red light illumination, and allowed choose...
Abstract Depression is a prevalent psychiatric disorder with an increasing impact in global public health. However, large proportion of patients treated currently available antidepressant drugs fail to achieve remission. Recently, antipsychotic have received approval for the treatment antidepressant-resistant forms major depression. The modulation adult neuroplasticity, namely hippocampal neurogenesis and neuronal remodeling, has been considered key role therapeutic effects antidepressants....
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in pathophysiology depression as modulators neurotransmission and neurovascular coupling. This evidenced by astrocyte impairments observed brains depressed patients appearance depressive-like behaviors upon astrocytic dysfunctions animal models. However, little known about importance de novo generated mammalian brain particular its possible involvement precipitation...
Abstract Objectives The action of stress hormones, mainly glucocorticoids, starts and coordinates the systemic response to stressful events. HPA axis activity is predicated on information processing modulation by upstream centres, such as hippocampus where adult‐born neurons (hABN) have been reported be an important component in integration new information. Still, it remains unclear whether how hABN regulates CORT production, particularly when considering sex differences. Materials Methods...
Changes in adult hippocampal cell proliferation and genesis have been largely implicated depression antidepressant action, though surprisingly, the underlying cycle mechanisms are undisclosed. Using both an vivo unpredictable chronic mild stress (uCMS) rat model of vitro hippocampal-derived neurosphere culture approaches, we aimed to unravel regulating after treatment. We show that dentate gyrus (hDG) uCMS animals less proliferating cells a decreased proportion G2/M phase, suggesting G1...