A5052881885- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Axon Guidance and Neuronal Signaling
- Epigenetics and DNA Methylation
- Nerve injury and regeneration
- Diet and metabolism studies
- Renal and related cancers
- Mesenchymal stem cell research
- Renal cell carcinoma treatment
- Anesthesia and Neurotoxicity Research
- Pharmacological Effects and Toxicity Studies
- Treatment of Major Depression
- Adenosine and Purinergic Signaling
- Mental Health Research Topics
- Quantum Dots Synthesis And Properties
- Yeasts and Rust Fungi Studies
- Healthcare Systems and Reforms
- Genetics, Aging, and Longevity in Model Organisms
- Urinary and Genital Oncology Studies
- Neuroscience, Education and Cognitive Function
University of Minho
2014-2024
University of Coimbra
2023
Hospital Beatriz Ângelo
2023
Instituto Português de Oncologia Francisco Gentil
2010-2013
Universidade do Porto
2011
Impairment of hippocampal neurogenesis has been associated with the expression depressive-like symptoms and some studies have suggested as a critical factor in normalization behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing is essential for maintenance behavioral homeostasis its pharmacological arrest precipitates commonly found depressed patients. Further, incorporation newly born neurons astrocytes into preexisting neurocircuitry shown to be necessary...
In recent years it has been shown that the therapeutic benefits of human mesenchymal stem/stromal cells (hMSCs) in Central Nervous System (CNS) are mainly attributed to their secretome. The implementation computer-controlled suspension bioreactors be a viable route for expansion these large numbers. As hMSCs actively respond culture environment, there is hypothesis one can modulate its secretome through use. Herein, we present data indicating use enhanced neuroregulatory profile Indeed,...
The three main types of urological cancers are mostly curable by surgical resection, if early detected. We aimed to identify novel DNA methylation biomarkers common these cancers, potentially suitable for non-invasive testing. From a candidate list markers created after gene expression assessment pharmacologically treated cell lines and tissue samples, two genes were selected further validation. Methylation levels quantified in total 12 cancer 318 clinical samples. PCDH17 TCF21 provided...
Abstract Depression is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in emotional cognitive domains. Neuroplastic phenomena are increasingly considered central to the etiopathogenesis of recovery from depression. Nevertheless, high number remitted patients experience episodes depression, remaining unclear how previous impact on behavior neuroplasticity and/or whether modulation important prevent Through re-exposure an unpredictable chronic mild stress...
There is accumulating evidence that adult neurogenesis and dendritic plasticity in the hippocampus are neuroplastic phenomena, highly sensitive to effects of chronic stress treatment with most classes antidepressant drugs, being involved onset recovery from depression. However, antidepressants act through selective inhibition monoamine oxidase subtype A (MAO-A) these phenomena still largely unknown. In present study, neuronal morphology were examined rats exposed mild (CMS) treated...
Abstract Chronic stress, a suggested precipitant of brain pathologies, such as depression and Alzheimer’s disease, is known to impact on plasticity by causing neuronal remodeling well neurogenesis suppression in the adult hippocampus. Although many studies show that stressful conditions reduce number newborn neurons dentate gyrus (DG), little about whether how stress impacts dendritic development structural maturation these neurons. We, herein, demonstrate chronic differentially doublecortin...
Abstract Depression is a prevalent psychiatric disorder with an increasing impact in global public health. However, large proportion of patients treated currently available antidepressant drugs fail to achieve remission. Recently, antipsychotic have received approval for the treatment antidepressant-resistant forms major depression. The modulation adult neuroplasticity, namely hippocampal neurogenesis and neuronal remodeling, has been considered key role therapeutic effects antidepressants....
Abstract Epidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with psychiatric disorders later in life. We recently reported anxiety exposure to dexamethasone (DEX, a synthetic glucocorticoid) correlates gender‐specific remodeling of microglia the medial prefrontal cortex (mPFC), core brain region anxiety‐related disorders. Gender differences morphology, higher prevalence women and negative impact...
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in pathophysiology depression as modulators neurotransmission and neurovascular coupling. This evidenced by astrocyte impairments observed brains depressed patients appearance depressive-like behaviors upon astrocytic dysfunctions animal models. However, little known about importance de novo generated mammalian brain particular its possible involvement precipitation...
Brain neuroplasticity is increasingly considered to be an important component of both the pathology and treatment depressive spectrum disorders. Recent studies shed light on relevance hippocampal cell genesis cortico-limbic dendritic plasticity for development remission from depressive-like behavior. However, neurobiological significance neuroplastic phenomena in this context still controversial. Here we summarize recent developments topic propose integrative interpretation data gathered so far.
Abstract Expression of PAX 2 (Paired‐box 2) is suppressed through promoter methylation at the later stages embryonic development, but eventually reactivated during carcinogenesis. Pax‐2 commonly expressed in most prevalent renal cell tumour ( RCT ) subtypes—clear RCC (cc ), papillary pRCC and oncocytoma—but not chromophobe (chr which frequently displays chromosome 10 loss (to mapped). Herein, we assessed epigenetic and/or genetic alterations affecting expression s evaluated its potential as...
The KRT19 gene encodes cytokeratin 19, an element of the cytoskeleton whose expression is frequently altered in renal cell carcinoma (RCC). Epigenetic phenomena, such as promoter methylation, may be a regulatory mechanism this gene. aim study was to assess epigenetic regulation using epigenetic-modulating drugs, through evaluation methylation and status region 6 lines 112 primary tumors (52 clear RCC, 22 papillary chromophobe 16 oncocytomas). diagnostic prognostic value levels RCC also...
Depression is a chronic debilitating disorder predicted to affect around 20% of the world population. Both brain and peripheral changes, including neuroplastic changes have been shown occur in brains depressed individuals animal models depression. Over past few decades, growing evidence has supported role miRNAs as regulators critical aspects plasticity function, namely context These molecules are not only highly expressed brain, but also relatively stable bodily fluids, blood. Previous...