A5076371505- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Adenosine and Purinergic Signaling
- Neurogenesis and neuroplasticity mechanisms
- Diet and metabolism studies
- Biochemical effects in animals
- Microbial Metabolic Engineering and Bioproduction
- Bioinformatics and Genomic Networks
- Lipid metabolism and disorders
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Neuropeptides and Animal Physiology
- Endoplasmic Reticulum Stress and Disease
- Neuroscience and Neuropharmacology Research
University of Lisbon
2020-2021
University of Coimbra
2019
Objective Receptor-interacting protein kinase 3 (RIPK3) is a key player in necroptosis execution and an emerging metabolic regulator, whose contribution to non-alcoholic fatty liver disease (NAFLD) controversial. We aimed clarify the impact of RIPK3 signalling pathogenesis human experimental NAFLD. Design levels were evaluated two large independent cohorts patients with biopsy proven NAFLD diagnosis correlated clinical biochemical parameters. Wild-type (WT) or Ripk3 -deficient ( −/− ) mice...
Microglia cells exert a critical role in brain development, mainly supported by their immune functions, which predicts an impact on the genesis of psychiatric disorders. In fact, microglia stress during gestation is, for instance, associated with chronic anxiety and cognitive deficits accompanied long-lasting, region- sex-specific changes morphology. We recently reported that pattern morphologic plasticity, is sex-determined, impacts anxious-like behaviour cognition. also pharmacologic...