A5005602169- Urinary Bladder and Prostate Research
- Mesenchymal stem cell research
- Pelvic floor disorders treatments
- Urological Disorders and Treatments
- Nerve injury and regeneration
- Traumatic Brain Injury and Neurovascular Disturbances
- Healthcare Systems and Public Health
- Neurological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Ion Channels and Receptors
- Neuroendocrine regulation and behavior
- Bladder and Urothelial Cancer Treatments
- Dermatology and Skin Diseases
- Extracellular vesicles in disease
- Cerebral Palsy and Movement Disorders
- Urinary Tract Infections Management
- Neuroscience of respiration and sleep
- Tissue Engineering and Regenerative Medicine
- Autophagy in Disease and Therapy
- Spinal Cord Injury Research
- Healthcare and Venom Research
University of Minho
2020-2025
Mario Negri Institute for Pharmacological Research
2021-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Universidade do Porto
2017-2022
Stemmatters (Portugal)
2022
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2019
Background and Purpose Spinal cord injury (SCI) is a neurological condition that affects motor sensory functions below the site. The consequences of SCI are devastating for patients, although significant efforts have been done in last years, there no effective therapy. Baclofen has emerged few years as an interesting drug field. Already used clinical setting to control spasticity, baclofen shown important impact on recovery animal models, such lampreys mice. Experimental Approach Key Results...
Mesenchymal stromal cells (MSCs) are widely used in preclinical models of traumatic brain injury (TBI). Results promising terms neurological improvement but hampered by wide variability treatment responses. We made a systematic review and meta-analysis: (1) to assess the quality evidence for MSC TBI rodent models; (2) determine effect size MSCs on sensorimotor function, cognitive anatomical damage; (3) identify MSC-related protocol-related variables associated with greater efficacy; (4)...
Abstract Neurodegenerative disorders and traumatic events affecting the central nervous system (CNS) represent one of main health problems nowadays. The level disability impairment these patients is very high, both at physiological psychological level, drastically altering a person's lifestyle. fact that CNS tissue has limited capacity regeneration hampered development possible therapies to conditions. specificity each disease also increases complexity creating strategies capable inducing...
Aim To study the contribution of urethral serotonin for urethro‐vesical crosstalk Methods Urethane‐anesthetized female rats and TPH1 −/− mice underwent isovolumetric or urethral‐opened cystometries during intravesical intraurethral infusion saline solutions. Human rat bladders urethrae were immunoreacted against neuronal markers. Serotonin concentration mRNA determined in tissue by HPLC qPCR. Results In rats, under conditions, infusion, but not saline, evoked bladder contractions. This was...
Traumatic brain injury (TBI) is a major worldwide neurological disorder with no neuroprotective treatment available. Three-dimensional (3D) in vitro models of contusion serving as screening platform for drug testing are lacking. Here we developed new model on organotypic cortical slices and tested its responsiveness to mesenchymal stromal cell (MSC) derived secretome. A focal TBI was induced by an electromagnetic impactor. Compared control condition, temporal increase death observed after...
Abstract The aim of this study was to determine whether aging‐related detrusor underactivity (DU) involves a decrease in 5‐hydroxytryptamine (5‐HT‐positive)‐expressing urethral cells and 5‐HT stimulation sensory fibers improves function. Cystometries were performed young (6 months) aged (18–24 female Wistar rats. Aged rats with voiding contractions (VC) that 2SD below the mean those considered have DU. Bladder efficiency (BVE) calculated during saline or solution cystometries. Rats...
Objectives. To investigate, in initial phases of bladder outlet obstruction (BOO), the urinary ATP levels, incidence detrusor underactivity (DU), and if they change after deobstruction. Methods. Adult female Wistar rats submitted to partial BOO (pBOO) sham-obstruction were used. Cystometry was performed 3 or 15 days pBOO fluid collected from urethra for determination. Bladders harvested morphological evaluation urothelium. DU defined as average voiding contractions (VC) sham-operated...
You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology Pharmacology I1 Apr 2017MP42-06 EXPRESSION AND FUNCTION OF SEROTONIN PARANEURONAL CELLS IN THE URETHRAL EPITHELIUM HUMAN RODENTS Ana Coelho, Raquel Oliveira, Helena Cavaleiro, Celia Duarte Cruz, and Francisco Cruz CoelhoAna Coelho More articles by this author , OliveiraRaquel Oliveira CavaleiroHelena Cavaleiro CruzCelia CruzFrancisco View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1295AboutPDF ToolsAdd...
Aim: Here, we investigated if MS-induced pain and bladder dysfunction can be attenuated by TRPV1 desensitization with RTX. Introduction: Multiple sclerosis (MS) is the most prevalent neurological disorder in young people, causing irreversible disability producing substantial economic social impact. Among incapacitating symptoms, neuropathic are reported majority of patients. The transient receptor potential vanilloid 1 (TRPV1) a described to have an important role pain, inflammation....
Event Abstract Back to Botulinum toxin A in the treatment of bladder dysfunction after spinal cord injury: beyond SNAP 25 cleavage Raquel Oliveira1, 2*, Sílvia S. Chambel1, 2, Helena Cavaleiro1, 2 and Célia D. Cruz1, 1 Faculty Medicine, University Porto, Portugal i3S, Instituto de Investigação e Inovação em Saúde, Introduction & Aims Bladder wall injections botulinum (BoNT/A) is gold-standard for neurogenic detrusor overactivity (NDO) (2), leading long-lasting improvements on function....