A5085929852- Neurogenesis and neuroplasticity mechanisms
- Stress Responses and Cortisol
- Zebrafish Biomedical Research Applications
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Axon Guidance and Neuronal Signaling
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Physiological and biochemical adaptations
- Lipid Membrane Structure and Behavior
- Remote Sensing in Agriculture
- Peroxisome Proliferator-Activated Receptors
- Stroke Rehabilitation and Recovery
- Color Science and Applications
- Impact of Light on Environment and Health
- Hypothalamic control of reproductive hormones
- Reproductive System and Pregnancy
- thermodynamics and calorimetric analyses
Universidade de Santiago de Compostela
2022-2024
Zebrafish (Danio rerio) has become a pivotal vertebrate model in biomedical research, renowned for its genetic similarity to humans, optical transparency, rapid embryonic development, and amenability experimental manipulation. In recent years, the derivation of cell lines from zebrafish embryos unlocked new possibilities vitro studies across developmental biology, toxicology, disease modeling, engineering. These embryo-derived cultures offer scalable, reproducible, ethically favorable...
Neogenin is a receptor mainly known for its roles during axon pathfinding. However, neogenin expressed in neuronal precursors of ventricular and subventricular zones the nervous system recent work has shown that it regulates adult neurogenesis. Here, we generated an antibody against sea lamprey to study expression larval spinal cord. Immunofluorescence experiments show ependymo-radial glial cells (ERGs) located ependymal region central canal mature lampreys. Our results provide basis future...
Abstract The expression of the corticotropin‐releasing hormone ( PmCRH ) and CRH‐binding protein PmCRHBP mRNAs was studied by in situ hybridization brain prolarvae, larvae, adults sea lamprey Petromyzon marinus . We also generated an antibody against mature peptide to study distribution PmCRH‐immunoreactive cells fibers. immunohistochemistry combined with antityrosine hydroxylase immunohistochemistry, hybridization, or neurobiotin transport from spinal cord. most numerous PmCRH‐expressing...
Sea lampreys are a vertebrate model of interest for the study spontaneous axon regeneration after spinal cord injury (SCI). Axon research in has focused on giant descending neurons, but less so neurochemically-distinct neuronal populations with small caliber axons. Corticotropin-releasing hormone (CRH) is neuropeptide that regulates stress response or locomotion. CRH also SCI context because CRHergic projections from Barrington's nucleus control micturition behavior mammals. Recent work our...
RGM interactions with its receptor Neogenin play an important role in the regulation of axonal guidance or cell death developing central nervous system. The sea lamprey
• Isothermal calorimetry was used to measure heat dissipation from zebrafish larvae. We found differences in coming different numbers of Larval show higher after a complete spinal cord injury.
Abstract The study of neurogenesis is essential to understanding fundamental developmental processes and for the development cell replacement therapies central nervous system disorders. Here, we designed an in vivo drug screening protocol developing zebrafish find new molecules signalling pathways regulating ventral spinal cord. This unbiased screen revealed that 4 cyclooxygenase (COX) inhibitors reduced generation serotonergic interneurons These results fitted very nicely with available...
Spinal cord injury (SCI) leads to severe functional deficits. Currently, there are no available pharmacological treatments promote neurological recovery in SCI patients. Recent work from our group has shown that a baclofen treatment can after compression mice [1]. Here, we provide transcriptomic (RNA-seq) data adult mouse spinal cords collected 7 days and (vs vehicle) administration. The Illumina NovaSeq 6000 platform was used generate the raw data. In addition, also present bioinformatic...
Abstract The expression of the corticotropin-releasing hormone ( PmCRH ) and CRH-binding protein PmCRHBP mRNAs was studied by in situ hybridization brain prolarvae, larvae adults sea lamprey Petromyzon marinus . We also generated an antibody against mature peptide to study distribution PmCRH-immunoreactive cells fibers. immunohistochemistry combined with anti-tyrosine hydroxylase immunohistochemistry, or neurobiotin transport from spinal cord. most numerous PmCRH-expressing were observed...