A5041234722- Lung Cancer Research Studies
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Calcium signaling and nucleotide metabolism
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
Stanford University
2022-2025
Intratumoral heterogeneity is a seminal feature of human tumors contributing to tumor progression and response treatment. Current technologies are still largely unsuitable accurately track phenotypes clonal evolution within tumors, especially in genetic manipulations. Here, we developed epitopes for imaging using combinatorial tagging (EpicTags), which coupled multiplexed ion beam (EpicMIBI) situ tracking barcodes tissue microenvironments. Using EpicMIBI, dissected the spatial component cell...
Patients with small-cell lung cancer (SCLC) are in dire need of more effective therapeutic options. Frequent disruption the G1 checkpoint SCLC cells creates a dependency on G2/M to maintain genomic integrity. Indeed, pre-clinical models, inhibiting kinase WEE1 shows promise growth. However, toxicity and acquired resistance limit clinical effectiveness this strategy. Here, using CRISPR-Cas9 knockout screens vitro vivo, we identified multiple factors influencing response inhibitor AZD1775,...