A5038959806- Peptidase Inhibition and Analysis
- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- RNA modifications and cancer
- Lung Cancer Research Studies
- Developmental Biology and Gene Regulation
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- ATP Synthase and ATPases Research
- Axon Guidance and Neuronal Signaling
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Biochemical and Molecular Research
- Microtubule and mitosis dynamics
- Brain Metastases and Treatment
- Advanced biosensing and bioanalysis techniques
- Advanced Data Storage Technologies
- Signaling Pathways in Disease
- Hippo pathway signaling and YAP/TAZ
- Folate and B Vitamins Research
Stanford University
2022-2024
Cornell University
2017-2022
Tata Institute of Fundamental Research
2018
Pediatrics and Genetics
2018
Radiation therapy is a mainstay of cancer treatment but does not always lead to complete tumor regression. Here we combine radiotherapy with blockade the 'don't-eat-me' cell-surface molecule CD47 in small cell lung (SCLC), highly metastatic form cancer. potently enhances local antitumor effects preclinical models SCLC. Notably, also stimulates off-target 'abscopal' inhibiting non-irradiated SCLC tumors mice receiving radiation. These abscopal are independent T cells require macrophages that...
A crucial step in cell differentiation is the silencing of developmental programs underlying multipotency. While much known about how lineage-specific genes are activated to generate distinct types, mechanisms driving suppression stemness far less understood. To address this, we examined regulation transcriptional network that maintains progenitor identity avian neural crest cells. Our results show a regulatory circuit formed by Wnt, Lin28a and let-7 miRNAs controls deployment subsequent...
Intratumoral heterogeneity is a seminal feature of human tumors contributing to tumor progression and response treatment. Current technologies are still largely unsuitable accurately track phenotypes clonal evolution within tumors, especially in genetic manipulations. Here, we developed epitopes for imaging using combinatorial tagging (EpicTags), which coupled multiplexed ion beam (EpicMIBI) situ tracking barcodes tissue microenvironments. Using EpicMIBI, dissected the spatial component cell...
Metastasis is a major cause of morbidity and mortality in patients with cancer, highlighting the need to identify improved treatment prevention strategies. Previous observations preclinical models tumors from small cell lung cancer (SCLC), fatal form high metastatic potential, identified transcription factor NFIB as driver tumor growth metastasis. However, investigation into requirement for activity metastasis relevant vivo needed establish therapeutic target. Here, using conditional gene...
<p>NFIB is not required for metastasis in tumors initiated from a neuroendocrine cell of origin the RPR2 mouse model</p>
<p>NFIBneg SCLC metastases show chromatin and transcriptional features related to ASCL1 activity</p>
<p>NFIBneg SCLC metastases show chromatin and transcriptional features related to ASCL1 activity</p>
<p>CUT&RUN analysis of FOXA1 binding in NFIBhigh and NFIBneg SCLC cells</p>
<p>CUT&RUN analysis of FOXA1 binding in NFIBhigh and NFIBneg SCLC cells</p>
<p>NFIBneg and NFIBhigh SCLC metastases display distinct chromosomal transcriptional feature</p>
<p>NFIB and MYC mRNA levels in human SCLC cell lines</p>
<p>TPM values from RNA-seq</p>
<p>Loss of CDH1 expression is not dependent on NFIB in RPR2 mutant mice</p>