A5030975938- Epigenetics and DNA Methylation
- Cutaneous Melanoma Detection and Management
- Genomics and Chromatin Dynamics
- Immunotherapy and Immune Responses
- Pain Mechanisms and Treatments
- Cancer Genomics and Diagnostics
- Ubiquitin and proteasome pathways
- Microtubule and mitosis dynamics
- Salivary Gland Tumors Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Animal Genetics and Reproduction
- RNA Research and Splicing
- Receptor Mechanisms and Signaling
- Mast cells and histamine
- Hereditary Neurological Disorders
- melanin and skin pigmentation
- vaccines and immunoinformatics approaches
- Ion channel regulation and function
- Oral and Maxillofacial Pathology
- Metastasis and carcinoma case studies
- 14-3-3 protein interactions
- Protein Degradation and Inhibitors
- Genetics and Neurodevelopmental Disorders
- Pluripotent Stem Cells Research
- Hippo pathway signaling and YAP/TAZ
Yale University
2024
Universidade de São Paulo
2016-2023
Center for Systems Biology
2022
Harvard University
2022
Cornell University
2022
Boston Children's Hospital
2022
AC Camargo Hospital
2015-2017
In melanoma development, oncogenic process is mediated by genetic and epigenetic mutations, few studies have so far explored the role of DNA methylation either as predisposition factor or biomarker. We tested patient samples for germline CDKN2A status found no evidence inactivation promoter hypermethylation. also investigated association clinical characteristics with pattern twelve genes relevant melanomagenesis. Five ( BAP1, MGMT, MITF, PALB2 , POT1 ) presented statistical between blood...
Epigenetic dysregulation is an important emerging hallmark of cutaneous melanoma development. The global loss DNA methylation in gene-poor regions and transposable elements cancer cells contributes to increased genomic instability. Long interspersed element-1 (LINE-1) sequences are the most abundant repetitive sequence genome can be evaluated as a surrogate marker level methylation. In this work, LINE-1 levels were melanomas normal melanocyte primary cell cultures investigate their possible...
Chronic pain is a major health issue, and the search for new analgesics has become increasingly important because of addictive properties unwanted side effects opioids. To explore potentially drug targets, we investigated mutations in NTRK1 gene found individuals with congenital insensitivity to anhidrosis (CIPA). encodes tropomyosin receptor kinase A (TrkA), nerve growth factor (NGF) that contributes nociception. Molecular modeling biochemical analysis identified decreased interaction...
Cutaneous melanoma (CM) is the most aggressive subtype of skin cancer, with increasing incidence over past several decades. DNA methylation a key element biological processes such as genomic imprinting, cell differentiation and senescence, deregulation this mechanism has been implicated in diseases, including cancer. In order to understand relationship CMs, we searched for an epigenetic signature cutaneous melanomas by comparing profiles between tumours benign melanocytes, precursor cells...
Conserved protein complexes establish and maintain cell polarity. In turn, polarity is indispensable for fundamental developmental processes such as asymmetric division of stem cells establishment subcellular membrane polarization during differentiation. There are three well characterized complexes. Atypical Protein Kinase C (aPKC) a conserved constituent the PAR complex that phosphorylates not only substrates within this complex, but also in other Outside aPKC regulates myriad cellular...