A5103064549- Growth Hormone and Insulin-like Growth Factors
- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Folate and B Vitamins Research
- Sexual Differentiation and Disorders
- Connective tissue disorders research
- Lipid metabolism and disorders
- Metabolism and Genetic Disorders
- Thyroid Disorders and Treatments
- Neonatal Respiratory Health Research
- Hypothalamic control of reproductive hormones
- Infant Development and Preterm Care
- Lysosomal Storage Disorders Research
- Neonatal and fetal brain pathology
- Diet and metabolism studies
- Congenital Ear and Nasal Anomalies
- Breastfeeding Practices and Influences
- Rheumatoid Arthritis Research and Therapies
- Glycogen Storage Diseases and Myoclonus
- Systemic Lupus Erythematosus Research
- Pituitary Gland Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Ophthalmology and Eye Disorders
- TGF-β signaling in diseases
- Pediatric Hepatobiliary Diseases and Treatments
National Hospital Organization
2015-2024
Okayama Medical Center
2015-2024
RELX Group (United States)
2017
National Defense Medical College
2016
AbbVie (Japan)
2013-2014
AbbVie (United States)
2013-2014
Okayama University
1992-2004
Okayama Prefecture
2001
Iwakuni Medical Center
1998-2000
Yamaguchi University
2000
To assess the bone growth status in healthy children, urinary pyridinoline (PYR) and deoxypyridinoline (DPYR) levels, which are specific resorption markers, were studied 192 aged 3-14 yr. In children ages 3-5 yr, PYR level was about 10 times higher than that adults (238.3 +/- 22.7 pmol/mumol Cr boys 261.8 14.2 girls; mean SE, declined gradually with age. boys, began to rise at yr of age peaked 2 later, declining thereafter. girls, rapidly after 11 The age-related changes DPYR levels closely...
To establish a sensitive marker for bone formation we have developed sandwich enzyme-linked immunosorbent assay intact osteocalcin (OC) and its propeptide. Serum levels of these peptides were studied in 185 normal children, aged 4-15 yr, 23 GH-deficient children treated with GH. The serum the propeptide prepubescent 1.43 +/- 0.23 (mean SE) micrograms/L boys 1.53 girls. peak value occurred at age 13 yr (2.91 0.42 micrograms/L) 11 girls (2.34 0.34 micrograms/L). OC 18.8 2.1 20.7 micrograms/L,...
A 17 year old boy was admitted because of short stature and hepatomegaly. He diagnosed with panhypopituitarism fatty liver. The liver improved, not hydrocortisone or levothyroxine treatment, but growth hormone administration. in this patient attributable to a deficient state.
OBJECTIVE Intensive studies of oestrogen receptors have suggested extragonadal functions oestrogen. However, the in vivo oestradiol remain unclear because lack an adequate assay system at low concentrations. In this study, we assessed usefulness a new ultrasensitive for children. METHODS Serum was measured with (assayable concentration: 5– 1835 pmol/l: ESTR‐US‐CT, CIS biointernational, France). Intra‐ and interassay coefficients variation concentrations (< 36·7 pmol/l) were 8·2 ± 6·8...
C1q deficiency is a rare disease that associated with high probability of developing systemic lupus erythematosus. We report 4-year-old Japanese girl who presented fever, facial erythema, joint pain, and oral ulceration. Complement deficiencies were suspected because her persistent hypocomplementemia normal levels the complement proteins C3 C4. identified novel homozygous splicing mutation in C1qB gene, c.187 + 1G > T, which first to be confirmed individual. Because treatment steroids...
The prevalence of metabolic syndrome is increasing in children and adolescents. Although some diagnostic criteria for exist, further research needed to determine appropriate age-, sex-, race-specific cutoffs each component.
This study assessed whether non-fasting lipid markers could be substituted for fasting in screening dyslipidemia, direct measurement of low-density lipoprotein cholesterol [LDL-C (D)] the calculation LDL-C (F)], and utility measuring non-high-density (non-HDL-C).In 33 children, profile was measured states within 24 h. Correlations were examined between (D) or non-HDL-C levels (F) levels.Non-fasting triglyceride (TG), total (TC), HDL-C, (D), all significantly higher than levels, but mean...
Insulin-like growth factor-I (IGF-I) is essential for FSH-dependent steroidogenesis by rat granulosa cells (GC), but whether IGF-I required other functions unknown. To investigate the role of in mechanisms FSH-stimulated inhibin α-subunit (Inh-α) production, GC were cultured with FSH, IGF-I, insulin-like factor-binding protein (IGFBP)-4, IGFBP-5, and/or anti-IGF-I antibody. Inh-α and mRNA levels measured conditioned medium Western immunoblotting Northern analysis, respectively. expression...
The objective of this study was to investigate the effect administration recombinant human growth hormone (hGH) in patients with Noonan syndrome. hGH administered (0.5 IU/kg/week) 15 syndrome over a 2 year period. Average patient age prior therapy 7.5 ± 2.5 (mean SD) yr, height SD score –2.8 0.7, and pretreatment velocity bone were 4.8 1.0 cm/yr 5.8 2.1 respectively. treatment, 0–12 12–24 months after commencing treatment cm/yr, 7.0 1.2 5.5 0.6 first significantly greater (P = 0.0001, n 14)...