A5053970708- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- T-cell and B-cell Immunology
- Urological Disorders and Treatments
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Multiple and Secondary Primary Cancers
- Cancer, Lipids, and Metabolism
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Anorectal Disease Treatments and Outcomes
National Hospital Organization
2005-2024
Kobe University
2013-2023
Kokura Memorial Hospital
2013-2023
New York Proton Center
2023
Communities In Schools of Orange County
2023
Manhattan Institute for Policy Research
2023
Oregon Medical Research Center
2023
Lindsay Unified School District
2023
King's College Hospital
2021
Kobe University Hospital
2013-2021
We previously demonstrated that CD82, expressed on both T cells and antigen-presenting (APC), plays an important role as a co-stimulatory molecule especially in the early phase of cell activation. also showed CD82 expression level is up-regulated activated memory cells. This up-regulation enhances cell-T cell-APC interactions. In this study, we further investigated mechanism CD82-mediated cell-cell adhesion. The enhanced adhesion between CD82-overexpressing Jurkat was completely blocked by...
We categorized the various types of post-obstetric injuries anorectum and vagina encountered in a five-year period. The operative procedures used to repair these functional outcome after surgery were assessed.Between 1986 1991, 52 patients surgically treated for obstetric vagina; 48 available follow-up study. Four clinical injury identified: Type I, incontinent sphincter (11 patients); II, rectovaginal fistula (16 III, IV, cloaca-like defect (10 patients). mean age was 30 years, duration...
Protein tyrosine phosphorylation is thought to be important for regulation of the proliferation, differentiation, and rapid turnover intestinal epithelial cells (IECs). The role protein phosphatases in such homeostatic IECs has remained largely unknown, however. Src homology 2-containing phosphatase (Shp2) a ubiquitously expressed cytoplasmic that functions as positive regulator Ras-mitogen-activated kinase (MAPK) signaling pathway operative downstream receptors various growth factors...
To define T cell co-stimulatory molecules that work in the early phase of activation, we established monoclonal antibodies (mAb) inhibit or enhance activation by histiocytic leukemia line U937. One mAb, 53H5, which recognized both cells and U937, was identified to bind CD82 expression cloning. Functional analyses revealed 1) needs exist on U937 for full cells; 2) is up-regulated stimulation such as CD3 ligation treatment with phorbol 12-myristate 13-acetate; 3) overexpression enhances...
Objective: This study aimed to determine whether retrocolic alimentary tract reconstruction is noninferior antecolic in terms of DGE incidence after pancreatoduodenectomy (PD) and investigated patients’ postoperative nutritional status. Summary Background Data: The influence the route on PD controversial. Methods: Patients from 9 participating institutions scheduled for were randomly allocated or groups. primary outcome was DGE, defined according 2007 version International Study Group...
This retrospective study was conducted to compare the treatment results between radical surgery and definitive chemoradiotherapy for resectable squamous cell carcinoma of esophagus. Between June 2000 May 2005, 82 consecutive patients were selected this in which 33 treated with 49 surgery. The (CRT) group received 2-4 cycles 5-fluorouracil (1000 mg/m(2)/day, day 1-4, continuous) combined cisplatin (75 mg/m(2), 1, bolus) plus 50.4 Gy radiation, while those by an esophagectomy node dissection....
The diagnosis of neonatal-onset protein C (PC) deficiency is challenging. This study aimed to establish the neonatal screening heritable PC in Japan. We determined changes plasma activity levels and S (PS) healthy neonates, studied newborn patients with PROC mutation Japanese registry. Physiological PS increased wide range. PC/PS-activity ratios converged after birth. 19 biallelic mutations, but not, 9 monoallelic mutation, were lower than those 13 without mutation. logistic regression...
Purpose To evaluate the kinetics of erythropoietin (EPO) production and address pathogenesis anemia prematurity, we measured EPO levels in infants during first year life. Patients Methods Using a radioimmunoassay, serum were 97 classified into three groups according to weight: group A, n = 40, <l,500 g; B, 19, 1,500–2,499 C, 38, ≥2,500 g. Results The level ranged widely early neonatal period from days 0 6 (group <5 307 mU/ml; 10–340 9–108 mU/ml). reached its lowest (<20 mU/ml) between 7 50...
We previously reported that biofilms and innate immunity contribute to the pathogenesis of Kawasaki disease. Therefore, we aimed assess efficacy clarithromycin, an antibiofilm agent, in patients with disease.We conducted open-label, multicenter, randomized, phase 2 trial at 8 hospitals Japan. Eligible included children aged between 4 months 5 years who were enrolled days illness. Participants randomly allocated receive either intravenous immunoglobulin (IVIG) or IVIG plus clarithromycin. The...
Solitary fibrous tumor (SFT) is a rare mesenchymal that typically arises from the pleura. Although it may appear in other organs, rarely develops pancreas. We report herein case of metastatic SFT pancreas originating an intracranial and subsequently identified as cystic neoplasm pancreas.A 58-year-old woman with past medical history brain visited hospital for further investigation tail. Abdominal imaging showed heterogeneously enhancing mass was initially suspected neuroendocrine neoplasm,...
Hypospadias is a congenital disease characterized by morphological abnormalities of the penis, including abnormal urethral opening and penile flexion, which cause urination disorders and/or sexual intercourse difficulty. Various factors have been suggested to this anomaly, but evidence concerning risk causing anomaly insufficient. We evaluated etiology hypospadias in Japan using Common Database National Hospitals' Neonatal study group.We retrospectively 7,865 male neonates registered NICU...
Pancreatic ductal adenocarcinoma (PDAC) has a high recurrence rate even after curative resection. Lung may have better outcomes than other recurrences. However, its detailed clinicopathological features are unclear. We investigated the and risk factors for lung pancreatectomy PDAC. The study included 161 patients with potentially borderline resectable PDAC who had undergone R0 or R1 between January 2008 December 2016. retrospectively examined prognosis predictors Seventeen (10.6%) isolated...
We report a case of successful laparoscopic distal gastrectomy with D2 lymph node dissection preserving the common hepatic artery branched from left gastric for advanced cancer an Adachi type VI (group 26) vascular anomaly. A 76-year-old female patient was admitted diagnosis at anterior wall to lesser curvature antrum (cT3N0M0 cStage IIA). Dynamic computed tomography showed ectopia artery. made anomaly and performed abovementioned operation. In this pattern, scrupulous attention is required...