A5066829132- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Aldose Reductase and Taurine
- Diabetes and associated disorders
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Vitamin C and Antioxidants Research
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Stress Responses and Cortisol
- Toxin Mechanisms and Immunotoxins
- Neuroendocrine Tumor Research Advances
- T-cell and B-cell Immunology
- Biochemical and Molecular Research
- Diabetes Management and Research
- Regulation of Appetite and Obesity
- Neurogenetic and Muscular Disorders Research
- Herbal Medicine Research Studies
- Hormonal Regulation and Hypertension
- Pharmacological Effects of Natural Compounds
- Muscle Physiology and Disorders
- Phytochemicals and Medicinal Plants
- Nitric Oxide and Endothelin Effects
Universidade de São Paulo
2011-2022
Universidade Federal do Paraná
2022
Fundação de Amparo à Pesquisa do Estado de São Paulo
2014
Institute of Biomedical Science
2013
Hospital Universitário da Universidade de São Paulo
2013
Universidade Federal de Juiz de Fora
2007
Progesterone has been associated with the development of gestational diabetes (GD) due to enhancement insulin resistance. As β-cell apoptosis participates in type 1 and 2 pathophysiology, we proposed hypothesis that progesterone might contribute GD through a mechanism also involves death. To address this question, RINm5F insulin-producing cells were incubated (25–100 μM), presence or absence α-tocopherol (40 μM). After 24 48 h, membrane integrity DNA fragmentation analyzed by flow cytometry....
G protein coupled receptor 40 (GPR40) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex have been shown to be involved in the fatty acid amplification of glucose-stimulated insulin secretion (GSIS). The effect palmitic on superoxide production by INS-1E cells possible involvement GPR40 NADPH these processes were examined this study. Cells incubated during 1 h with low high glucose concentrations, a agonist (GW9508) inhibitors (diphenyleneiodonium, DPI) PKC (calphostin...
Epidemiological studies have shown a strong correlation between stressful events (nutritional, hormonal or environmental) in early life and development of adult diseases such as obesity, diabetes cardiovascular failure. It is known that gestation lactation are crucial periods for healthy growth mammals the sympathoadrenal system markedly influenced by environmental conditions during these periods. We previously demonstrated neonatal hyperleptinaemia rats programmes higher body weight, food...
The aim of this study was to evaluate the effect a high-fat diet (HFD) on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in rat pancreatic islets. We investigated if changes NADPH are connected beta cell dysfunction reported obese animals.Male Wistar rats were fed HFD or control for 3 months. DNA fragmentation, insulin secretion, and [U-C]glucose oxidation examined isolated oxidative stress markers nitrotyrosine 4-hydroxy-2-nonenal assessed by immunohistochemistry....
High affinity binding sites for pancreastatin were identified the first time, and their molecular characterization was performed with rat liver membranes. Using 125I-pancreastatin, we have studied interaction of Cross-linking tracer to membranes using bifunctional reagent dithiobis(succinimidyl propionate). Analysis under equilibrium conditions indicated existence one class sites, a Bmax 15 fmol/mg protein an apparent Kd 0.2 nM. The cross-linking 125I-pancreastatin revealed single band M(r)...
Metformin is the first-line drug to treat type 2 diabetes mellitus. Its mechanism of action still debatable, and recent studies report that metformin attenuates oxidative stress. This study evaluated in vitro antioxidant effects a broad range concentrations on insulin-producing cells. The cell cycle, metabolism, glucose-stimulated insulin secretion, death were determine biguanide beta-cell function survival. Antioxidant potential was based reactive oxygen species (ROS), reduced glutathione...