A5103147942- Estrogen and related hormone effects
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Science, Research, and Medicine
- Advanced Glycation End Products research
- NF-κB Signaling Pathways
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related Molecular Pathways
- Diabetes and associated disorders
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Inflammasome and immune disorders
- GDF15 and Related Biomarkers
- Histone Deacetylase Inhibitors Research
- Genomics, phytochemicals, and oxidative stress
- Synthesis of Tetrazole Derivatives
- interferon and immune responses
- Apelin-related biomedical research
- Inflammatory mediators and NSAID effects
- Retinoids in leukemia and cellular processes
- Nutrition, Genetics, and Disease
Bombay College of Pharmacy
2021
The University of Texas Southwestern Medical Center
2013-2016
Texas A&M University
2003-2011
Regional Health
2009
National Cancer Center
2009
The University of Texas MD Anderson Cancer Center
2009
Jeonbuk National University
2009
The University of Texas Health Science Center at Houston
2009
Orlando Health
2009
Mitchell Institute
2006-2007
Abstract Nerve growth factor–induced Bα (NGFI-Bα, Nur77) is an orphan nuclear receptor with no known endogenous ligands; however, recent studies on a series of methylene-substituted diindolylmethanes (C-DIM) have identified 1,1-bis(3′-indolyl)-1-(phenyl)methane (DIM-C-Ph) and 1,1-bis(3′-indolyl)-1-(p-anisyl)methane (DIM-C-pPhOCH3) as Nur77 agonists. expressed in several colon cancer cell lines (RKO, SW480, HCT-116, HT-29, HCT-15), we also observed by immunostaining that was overexpressed...
TANK-binding kinase 1 (TBK1) is a serine/threonine protein that plays crucial role in innate immunity. Enhanced TBK1 function associated with autoimmune diseases and cancer, implicating the potential benefit of therapeutically targeting TBK1. In this article, we examined recently identified inhibitor Compound II on treating diseases. We found potent specific TBK1-mediated IFN response. inhibited polyinosinic-polycytidylic acid-induced immune activation vitro vivo. treatment also ameliorated...
NR4A1 (Nur77, TR3) is overexpressed in pancreatic tumors and activation of TR3 by 1,1-bis(3′-indolyl)-1-( p -methoxyphenyl)methane (DIM-C-pPhOCH 3 ) inhibits cell tumor growth induces apoptosis. Microarray analysis demonstrates that L3.6pL cancer cells DIM-C-pPhOCH genes associated with metabolism, homeostasis, signal transduction, transcription, stress, transport, immune responses, inhibition Among the most highly induced inhibitory proapoptotic including activating transcription factor...
The cad gene is trifunctional and expresses carbamoylphosphate synthetase/aspartate carbamyltransferase/dihydroorotase, which are required for pyrimidine biosynthesis. Cad activities induced in MCF-7 human breast cancer cells, treatment of or ZR-75 cells with 10 nm 17β-estradiol (E2) resulted a 3- to 5-fold increase mRNA levels both cell lines. mechanism hormone-induced expression was further investigated using constructs containing the growth-responsive −90 +115 (pCAD1) region promoter. E2...
The aryl hydrocarbon receptor (AhR) binds with high affinity to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related halogenated aromatics, but also lower structurally diverse exogenous endogenous chemicals. One study reported that 3-methylcholanthrene (3MC) activated the estrogen (ER) through AhR, which acts as co-regulatory protein, whereas a recent report showed 3MC directly bound ERalpha. This shows AhR agonists benzo[a]pyrene, 3,3',4,4'-tetrachlorobiphenyl, chrysin,...
Nerve growth factor-induced B (NGFI-B) genes are orphan nuclear receptors, and NGFI-Bα (Nur77, TR3) is overexpressed in bladder tumors cancer cells compared with nontumorous tissue. 1,1-Bis(3′-indolyl)-1-(<i>p</i>-methoxyphenyl)-methane (DIM-C-pPhOCH<sub>3</sub>) 1,1-bis(3′-indolyl)-1-(<i>p</i>-phenyl)methane have previously been identified as activators of Nur77, both compounds inhibited induced apoptosis UC-5 KU7 cells. The proapoptotic effects methylene-substituted diindolylmethanes...
The trifunctional carbamoylphosphate synthetase/aspartate transcarbamyltransferase/dihydroorotase (CAD) gene is hormone responsive in MCF-7 and ZR-75 breast cancer cells, this response inhibited by the aryl hydrocarbon receptor (AhR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Estrogen-dependent induction of CAD mRNA reporter activity cells transfected with constructs (pCAD) containing hormone-responsive GC-rich promoter inserts involves estrogen alpha (ERalpha)/Sp1 interactions...
Abstract Deletion analysis of several 17β-estradiol (E 2 )-responsive genes have identified GC-rich sites that are associated with hormone-induced transactivation in MCF-7 breast cancer cells. However, the role individual specificity proteins (Sps) mediating gene expression has not been unequivocally determined. In transient transfection studies using E -responsive promoters from F1, carbamoylphosphate synthetase/aspartate transcarbamylase/dihydroorotase (CAD), and retinoic acid receptor α...
Abstract C57BL/6 mice bearing the Sle2z lupus-susceptibility congenic interval on chromosome 4 display high titers of polyclonal autoantibodies with generalized B cell hyperactivity, hallmarks systemic lupus erythematosus. In B6.Sle2zHELIg.sHEL BCR-transgenic mice, did not breach central tolerance, but it led to heightened expression endogenous Ig H and L chains in splenic cells, upregulation RAG, serological polyreactivity, suggestive excessive receptor revision. Fatty acid amide hydrolase...