A5044849339- Blood groups and transfusion
- Erythrocyte Function and Pathophysiology
- Genomics and Phylogenetic Studies
- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- Hemoglobinopathies and Related Disorders
- Bacteriophages and microbial interactions
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Tannin, Tannase and Anticancer Activities
- Cancer, Lipids, and Metabolism
- Infections and bacterial resistance
- Mechanisms of cancer metastasis
- Biochemical and Molecular Research
- Plant-Microbe Interactions and Immunity
- Microbial Natural Products and Biosynthesis
- Fetal and Pediatric Neurological Disorders
- Pharmacogenetics and Drug Metabolism
- Blood disorders and treatments
- Microbial Community Ecology and Physiology
- Escherichia coli research studies
- Genomics and Rare Diseases
- Plant responses to water stress
- Plant Stress Responses and Tolerance
- Plant Pathogenic Bacteria Studies
Queensland University of Technology
2019-2024
Australian Red Cross Lifeblood
2023-2024
Translational Research Institute
2021-2022
University of Macau
2018
The human genome is mostly transcribed, yielding a rich repository of noncoding transcripts that are involved in myriad biological processes including cancer. However, how many such as long RNAs (lncRNA) function cancer still unclear. This study identified novel set clinically relevant androgen-regulated lncRNAs prostate Among this group, LINC00844 was demonstrated to be direct target actively transcribed androgen receptor (AR)-dependent cells. expression higher normal compared with...
Background: Population genomic studies of individuals Indigenous ancestry have been extremely limited comprising <0.5% participants in international genetic databases and genome-wide association studies, contributing to a “genomic gap” that limits their access personalised medicine. While Australians face high burden chronic disease associated medication exposure, corresponding drug safety datasets are sorely lacking. Methods: To address this, we conducted pharmacogenomic study almost...
A cross between IR64 (high-yielding but drought-susceptible) and Aday Sel (drought-tolerant) rice cultivars yielded a stable line with enhanced grain yield under drought screening field trials at International Rice Research Institute. The major effect qDTY4.1 tolerance QTL was detected in the IR77298-14-1-2-10 Backcrossed Inbred Line (BIL) its IR87705-7-15-B Near Isogenic (NIL) 93.9% genetic similarity to IR64. Although is extremely susceptible water stress reproductive stage, currently,...
While blood transfusion is an essential cornerstone of hematological care, patients requiring repetitive remain at persistent risk alloimmunization due to the diversity human group polymorphisms. Despite promise, user friendly methods accurately identify types from next-generation sequencing data are currently lacking. To address this unmet need, we have developed RBCeq, a novel genetic typing algorithm 36 systems.RBCeq can predict complex groups such as RH, and ABO that require...
Abstract Elizabethkingia anophelis has now emerged as an opportunistic human pathogen. However, its mechanisms of transmission remain unexplained. Comparative genomic (CG) analysis E. anopheles endophthalmitis strain surprisingly found from eye infection patient with twenty-five other genomes revealed potential to participate in horizontal gene transfer. CG that the study isolate open pan genome and undergone extensive rearrangements. We demonstrate is naturally competent, hitherto not...
We report the draft genome sequence of Alcaligenes faecalis strain IITR89, a bacterium able to form indigo by utilizing indole as sole carbon source. The species is increasingly reported for biodegradation diverse toxicants and thus complete sequencing may provide insight into capabilities other phenotypes.
Abstract Background Red blood cell (RBC) membrane‐associated group systems are clinically significant. Alloimmunisation is a persistent risk associated with transfusion owing to the antigen polymorphisms among these RBC‐associated groups. Next‐generation sequencing (NGS) offers an opportunity characterize variant profile of given individual. Australia comprises large multiethnic population where most donors Caucasian and variants remain poorly studied Indigenous Australians. In this study,...
ABSTRACT Halobacillus sp. strain KGW1 is a moderately halophilic, rod shaped, Gram-positive, yellow pigmented, alkaline protease-producing bacterium isolated from water sample Chilika Lake, Odisha, India. Sequencing of bacterial DNA assembled 3.68-Mb draft genome. The genome annotation analysis showed various gene clusters for tolerance to stress, such as elevated pH, salt concentration, and toxic metals.
We report the 4.51 Mb draft genome of Pseudomonas sp. strain BMS12, a Gram-negative bacterium in class Gammaproteobacteria, isolated from rhizospheric sediment Phragmites karka, an invasive weed Chilika Lake, Odisha, India. The BMS12 is capable producing proteases and also efficient plant growth promoter that can be useful for various phytoremedial industrial applications.
ABSTRACT We report the 3.16 Mb draft genome of Acinetobacter sp. strain BMW17, a Gram-negative bacterium in class Gammaproteobacteria , isolated from rhizospheric region Phragmites karka an invasive weed Chilika Lake, Odisha, India. The BMW17 T is capable degrading cellulose and also efficient plant growth promoter that can be useful for various phytoremedial commercial applications.
Hematological disorders are often treated with blood transfusions. Many group antigens and variants population-specific, for patients rare types, extensive donor screening is required to find suitable matches transfusion. There a scarcity of knowledge regarding in Aboriginal Australian populations, despite higher need transfusion due the prevalence renal diseases anaemia.
Abstract Background We report an obstetric case involving RhD‐positive woman who had developed a red blood cell (RBC) antibody that was not detected until after delivery of newborn, presented with positive direct antiglobulin test result. Immunohematology studies suggested the maternal directed against low‐prevalence antigen on paternal and newborn RBCs. Results Comprehensive group profiling by targeted exome sequencing revealed novel nonsynonymous single nucleotide variant (SNV) RHCE...
Here, we report the 4.16-Mb draft genome sequence of an indole-degrading bacterium, Acinetobacter baumannii IITR88, isolated from Bhagirathi river in India. A total 4,069 coding regions (CDSs), 3 rRNAs, and 52 tRNAs were predicted. Genes for degradation indoles, phenylacetaldehyde, anthranilate, several other aromatic compounds present.
There have been no comprehensive studies of a full range blood group polymorphisms within the Australian population. This problem is compounded by absence any databases carrying genomic information on chronically transfused patients and low frequency antigens in Australia. Here, we use RBCeq, web server-based genotyping software, to identify unique variants among Australians compare variation detected vs global data. Whole-genome sequencing data were analyzed for 2796 healthy older from...
We report the draft genomes of two extensively drug-resistant (XDR)Acinetobacter baumanniistrains isolated from pus samples patients with surgical site infections at Sri Sathya Sai Institute Higher Medical Sciences, Prasanthigram, India. The average genomic size and G+C content are 4 Mbp 38.96% (AB28) 38.94% (AB30), respectively.
Abstract Background Blood groups form the basis of effective and safe blood transfusion. There are about 41 well recognized human group systems presently known. molecularly determined by presence specific antigens on red cells genetically inherited following Mendelian principles. The lack a comprehensive, relevant, manually compiled genome-ready dataset cell limited widespread application genomic technologies to characterise interpret complement an individual from datasets. Materials Methods...
Blood groups form the basis of effective and safe blood transfusion. There are about 43 well-recognised human group systems presently known. molecularly determined by presence specific antigens on red cells genetically inherited following Mendelian principles. The lack a comprehensive, relevant, manually compiled genome-ready dataset cell limited widespread application genomic technologies to characterise interpret complement an individual from datasets.A range public datasets was used...
Abstract The majority of the human genome is transcribed, yielding a rich repository non-coding transcripts that are involved in myriad biological processes including cancer. However, how such as long RNAs (lncRNAs) function prostate cancer still unclear. In this study, we have identified novel set clinically relevant androgen-regulated lncRNAs Among group, showed LINC00844 direct target actively transcribed androgen receptor (AR)-dependent cells. expression higher normal compared to...
We present the draft genome assembly of an extensively drug-resistant (XDR)Pseudomonas aeruginosastrain isolated from a patient with history genito urinary tuberculosis. The is 7,022,546 bp G+C content 65.48%. It carries 7 phage genomes, genes for quorum sensing, biofilm formation, virulence, and antibiotic resistance.
Improvements in blood group genotyping methods have allowed large scale population-based genetics studies, facilitating the discovery of rare antigens. Norfolk Island, an external and isolated territory Australia, is one example underrepresented segment broader Australian population. Our study utilized whole genome sequencing data to characterize 43 systems 108 Island residents. Blood genotypes phenotypes across were predicted using RBCeq. Predicted frequencies compared available from 1000G...
<p>S1. The relative expression of KLK3/PSA. S2. Kaplan-Meier analysis prostate cancer outcome was obtained from GEPIA tool. S3. LNCaP cells with the indicated treatments were seeded in upper chamber Boyden's transwell chamber. S4. which coated 1:20 diluted Matrigel. S5. S6. Snapshots form AR ChIP-seq showing binding to ARBS. S7. Screenshot shows marked reduction ARBS located at ~ 30kb NDRG1 after LINC00844 knock-down cells. S8. S9. we co-transfected siRNA and plasmids S10. harvested...