A5060215865- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Folate and B Vitamins Research
- Prenatal Screening and Diagnostics
- Blood groups and transfusion
- Parathyroid Disorders and Treatments
- Erythrocyte Function and Pathophysiology
- Pregnancy and preeclampsia studies
- Diabetes Treatment and Management
- COVID-19 and healthcare impacts
- Telemedicine and Telehealth Implementation
- Blood disorders and treatments
- Vector-borne infectious diseases
- Blood donation and transfusion practices
- Cell Adhesion Molecules Research
- Safety Warnings and Signage
- Neurological and metabolic disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mobile Health and mHealth Applications
- RNA modifications and cancer
- Maternal and fetal healthcare
- Neutropenia and Cancer Infections
- Glycogen Storage Diseases and Myoclonus
- Inflammatory Biomarkers in Disease Prognosis
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2024
Dana-Farber Brigham Cancer Center
2016-2024
Dana-Farber Cancer Institute
2016-2024
John Wiley & Sons (United States)
2021
Hudson Institute
2021
Yale University
2019
Indiana University – Purdue University Indianapolis
2019
University of North Carolina at Chapel Hill
2019
Indiana University School of Medicine
2019
Sickle cell disease is characterized by hemolytic anemia, pain, and progressive organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α- γ-globins may ameliorate these manifestations mitigating sickle polymerization sickling.
Intravenous iron enables rapid correction of iron-deficiency anemia, but certain formulations induce fibroblast growth factor 23-mediated hypophosphatemia.To compare risks hypophosphatemia and effects on biomarkers mineral bone homeostasis intravenous isomaltoside (now known as ferric derisomaltose) vs carboxymaltose.Between October 2017 June 2018, 245 patients aged 18 years older with anemia (hemoglobin level ≤11 g/dL; serum ferritin ≤100 ng/mL) intolerance or unresponsiveness to 1 month...
Background: Laboratory reference intervals must reflect population diversity for accurate medical decisions. The Duffy null variant lowers absolute neutrophil counts (ANC), but existing dedicated are based on a single African American cohort. impact across other ethnic groups and regions remains unclear, no white blood cell count (WBC) exist individuals. This study aimed to establish compare ANC WBC four continents. Methods: A cross-sectional was conducted assessing healthy individuals from...
Background Babesiosis, a tickborne zoonotic disease caused by intraerythrocytic protozoa of the genus babesia, is characterized nonimmune hemolytic anemia that resolves with antimicrobial treatment and clearance parasitemia. The development warm-antibody autoimmune (also known as warm [WAHA]) in patients babesiosis has not previously been well described. Methods After observation sporadic cases WAHA occurred after for babesiosis, we conducted retrospective cohort study all who were cared at...
This study establishes a Duffy null phenotype–specific absolute neutrophil count reference range to optimize care and improve health equity.
Abstract The COVID-19 pandemic has highlighted racial health disparities within the United States. Although social determinants of are most likely drivers this disparity, it is possible that genetic traits enriched in black population like sickle cell trait (SCT) could worsen morbidity and mortality infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients admitted for SARS-CoV-2 who identified as or African American were included study (n = 166). Blood remnants...
Abstract Problem Approximately 100,000 individuals in the United States have sickle cell disease (SCD). These face multiple barriers to equitable care. At Brigham and Women’s Hospital, existing health inequities for these patients were compounded by admitting, rounding, team structures that assigned with SCD medicine teams a hematologist attending, leading delays patient care gaps residents’ hematology knowledge. Approach A hematology–general hybrid was created September 2021 enhance trainee...
Because of misperceptions about risks, people with sickle cell trait in the United States may receive inequitable and potentially harmful treatment, implications for autonomy, privacy, justice.
Abstract Objectives Bone marrow transplantation (BMT) is currently the only curative therapy available for patients with sickle cell disease (SCD), but clinical outcomes in routine care are not well understood. We describe rates of vaso‐occlusive crises (VOCs), transplant complications, and mortality SCD after BMT. Methods A cohort study who underwent BMT was designed using US Medicaid claims data (2000‐2013). Results total 204 undergoing were identified a mean (SD) age 10.6 (7.3) years,...