A5064643623- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Autoimmune and Inflammatory Disorders Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Hematological disorders and diagnostics
- Chronic Lymphocytic Leukemia Research
- Cell Adhesion Molecules Research
- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Immunodeficiency and Autoimmune Disorders
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Platelet Disorders and Treatments
- Hematopoietic Stem Cell Transplantation
- Protein Degradation and Inhibitors
- Iron Metabolism and Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- RNA Interference and Gene Delivery
- Heparin-Induced Thrombocytopenia and Thrombosis
- Protease and Inhibitor Mechanisms
Brigham and Women's Hospital
2015-2024
Harvard University
2014-2023
American Association of Blood Banks
2022
Massachusetts General Hospital
2006-2016
Harvard University Press
2015
Dana-Farber Cancer Institute
2006-2014
Nirma (India)
2012
University of Missouri
2012
Yale University
1999-2008
Baptist Medical Center Jacksonville
2006
Background: Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and recommended first-line agent rheumatoid arthritis. Despite extensive clinical use more than 30 years, few data on adverse event (AE) rates derive from randomized, placebo-controlled trials, where both causality magnitude of risk can be inferred. Objective: To investigate AE rates, risk, differences comparing LD-MTX versus placebo. Design: Prespecified secondary analyses a...
Clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia undetermined significance (CCUS) are defined by somatic mutations in genes associated with myeloid neoplasms (MN) at a variant allele fraction (VAF) ≥ 0.02, the absence presence cytopenia, respectively. CHIP/CCUS is highly prevalent adults defining predictors MN risk would aid clinical management research.
T cell-mediated hyperinflammatory responses, such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity (ICANS), are now well-established toxicities of chimeric antigen receptor (CAR) cell therapy. As the field CAR cells advances, however, there is increasing recognition that hemophagocytic lymphohistiocytosis (HLH)-like following infusion occurring broadly across patient populations constructs. Importantly, these HLH-like often not directly associated with CRS...
Summary Haemophagocytic lymphohistiocytosis ( HLH ) is a syndrome of uncontrolled immune activation that has gained increasing attention over the past decade. Although classically known as familial disorder children caused by mutations affect cytotoxic T‐cell function, an acquired form in adults now widely recognized. This often seen setting malignancy, infection or rheumatological disorders. We performed retrospective review across 3 tertiary care centres and identified 68 with . The...
Recent molecular studies of myeloid differentiation have utilized several in vitro models myelopoiesis. Hematopoietic progenitors expressing the CD34+ antigen can be induced a process that recapitulates normal development. Two human leukemic cell lines, NB-4 and HL-60, been demonstrated to undergo retinoic acid-induced development, however, both lines exhibit defects upregulation late-expressed neutrophil-specific genes. In contrast, two murine factor-dependent myelopoiesis express full...
Abstract Anemia is a significant problem in elderly patients. Although many anemic patients can be diagnosed with nutritional deficiency, anemia of chronic inflammation or comorbid diseases that explain their decreased hematocrit, the etiology fraction remains obscure. There evidence to suggest hematopoietic stem cell displays increasing erythropoietin (EPO) resistance age. EPO levels rise elderly, nonanemic patients, and it hypothesized there an interplay between this rising demand for...